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Vitamin D receptor polymorphisms and Parkinson's disease in a Korean population: Revisited.
Neurosci Lett. 2016 08 15; 628:230-5.NL

Abstract

Recently, the effect of genetic variants in the Vitamin D receptor (VDR) gene on Parkinson's disease (PD) has gained interest. However, the precise relationship between VDR polymorphisms and PD remains unclear. In Korea, one study reported an association between VDR gene polymorphisms and PD. However, this study was conducted with a small sample size, and only the Bsml locus was evaluated. Therefore, further investigations about the relationship between VDR polymorphisms and PD are necessary in a Korean population. A total of 300 subjects were included in this study. One hundred and forty-six PD patients were diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UKPDBB) criteria with abnormal dopamine transporter imaging, and 154 healthy control subjects were also enrolled. We used a TaqMan genotyping assay to identify four SNPs of the VDR gene, including BsmI, FokI, ApaI, and TaqI (rs731236, rs2228570, rs7976091, and rs731236). A significant association was not noted between the risk of PD and genetic polymorphisms in the four loci in a Korean population. However, when the genetic variants of the VDR gene were analyzed after adjusting for the serum 25-OH vitamin D3 level, the TaqI and BsmI minor allele increased the risk of PD. Our data suggest no correlation between PD and the VDR polymorphisms, including BsmI, FokI, ApaI, and TaqI, in a Korean population; however, the results should be interpreted carefully because gene-environment interactions may exist. Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD.

Authors+Show Affiliations

Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olymphic-ro 43 Gil, Songpa-gu, Seoul, Republic of Korea.Department of Biostatistics, Soonchunhyang University Hospital, Daesagwan-ro 59, Yongsan-gu, Seoul, Republic of Korea.Department of Neurology, Chungnam National University College of Medicine, Chungnam National University Hospital, Munhwa-ro 282, Jung-gu, Daejeon, Republic of Korea.Department of Neurology, Inje University, Haeundae Paik Hospital, Jwa-dong 1435, Haeundae-gu, Busan, Republic of Korea.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-ro 81, Gangnam-gu, Seoul, Republic of Korea.Department of Neurology, Soonchunhyang University Hospital, Daesagwan-ro 59, Yongsan-gu, Seoul, Republic of Korea.Department of Laboratory Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Bangdong-ri, Sacheon-myeon, Gangneung-si, Gangwon-do, Republic of Korea.Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Bangdong-ri, Sacheon-myeon, Gangneung-si, Gangwon-do, Republic of Korea. Electronic address: neveu@gnah.co.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27345382

Citation

Kang, Seo Young, et al. "Vitamin D Receptor Polymorphisms and Parkinson's Disease in a Korean Population: Revisited." Neuroscience Letters, vol. 628, 2016, pp. 230-5.
Kang SY, Park S, Oh E, et al. Vitamin D receptor polymorphisms and Parkinson's disease in a Korean population: Revisited. Neurosci Lett. 2016;628:230-5.
Kang, S. Y., Park, S., Oh, E., Park, J., Youn, J., Kim, J. S., Kim, J. U., & Jang, W. (2016). Vitamin D receptor polymorphisms and Parkinson's disease in a Korean population: Revisited. Neuroscience Letters, 628, 230-5. https://doi.org/10.1016/j.neulet.2016.06.041
Kang SY, et al. Vitamin D Receptor Polymorphisms and Parkinson's Disease in a Korean Population: Revisited. Neurosci Lett. 2016 08 15;628:230-5. PubMed PMID: 27345382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor polymorphisms and Parkinson's disease in a Korean population: Revisited. AU - Kang,Seo Young, AU - Park,Suyeon, AU - Oh,Eungseok, AU - Park,Jinse, AU - Youn,Jinyoung, AU - Kim,Ji Sun, AU - Kim,Jeong-Uk, AU - Jang,Wooyoung, Y1 - 2016/06/21/ PY - 2016/04/25/received PY - 2016/06/03/revised PY - 2016/06/20/accepted PY - 2016/6/28/entrez PY - 2016/6/28/pubmed PY - 2017/6/14/medline KW - Parkinson's disease KW - Single nucleotide polymorphism KW - South Korea KW - Vitamin D receptor SP - 230 EP - 5 JF - Neuroscience letters JO - Neurosci Lett VL - 628 N2 - Recently, the effect of genetic variants in the Vitamin D receptor (VDR) gene on Parkinson's disease (PD) has gained interest. However, the precise relationship between VDR polymorphisms and PD remains unclear. In Korea, one study reported an association between VDR gene polymorphisms and PD. However, this study was conducted with a small sample size, and only the Bsml locus was evaluated. Therefore, further investigations about the relationship between VDR polymorphisms and PD are necessary in a Korean population. A total of 300 subjects were included in this study. One hundred and forty-six PD patients were diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UKPDBB) criteria with abnormal dopamine transporter imaging, and 154 healthy control subjects were also enrolled. We used a TaqMan genotyping assay to identify four SNPs of the VDR gene, including BsmI, FokI, ApaI, and TaqI (rs731236, rs2228570, rs7976091, and rs731236). A significant association was not noted between the risk of PD and genetic polymorphisms in the four loci in a Korean population. However, when the genetic variants of the VDR gene were analyzed after adjusting for the serum 25-OH vitamin D3 level, the TaqI and BsmI minor allele increased the risk of PD. Our data suggest no correlation between PD and the VDR polymorphisms, including BsmI, FokI, ApaI, and TaqI, in a Korean population; however, the results should be interpreted carefully because gene-environment interactions may exist. Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/27345382/Vitamin_D_receptor_polymorphisms_and_Parkinson's_disease_in_a_Korean_population:_Revisited_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(16)30450-5 DB - PRIME DP - Unbound Medicine ER -