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[Effects of statin intervention on mild coronary plaque progression assessed by serial coronary CT angiography].
Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jun 24; 44(6):508-12.ZX

Abstract

OBJECTIVE

To assess the effects of statin treatment on mild coronary plaque progression by serial coronary CT angiography.

METHODS

A total of 120 consecutive patients (74 men, ages(58.9±8.1)years) with mild (≤50%luminal narrowing and lesion length<20 mm) non-calcified plaque detected by coronary CT angiography during September 2012 and December 2013 were prospectively enrolled in this study.Subjects were divided into three groups: no statin (n=36), statin lowering LDL-C <50% (n=43), and statin lowering LDL-C ≥50%(n=41). Serial scans were performed after a median interval of 705 (interquartile range: 467, 803) days.Total plaque volume, percent plaque volume for both baseline and follow-up were measured.Baseline and follow-up data were compared.

RESULTS

Compared with baseline, total plaque volume in no statin group showed increasing trend by the end of follow-up ((97.3±57.8) mm(3) vs. (82.2±57.7) mm(3,) P=0.075). However, no significant change was observed as for total plaque volume ((78.5±45.2) mm(3) vs.(77.6±50.5) mm(3), P=0.910) in the statin lowering LDL-C <50% group.Total plaque volume was significantly reduced by the end of follow-up ((61.5 ± 46.1) mm(3) vs.(77.7±48.1) mm(3), P=0.024) in the statin lowering LDL-C ≥50% group.Percent plaque volume in no statin group was significantly increased by the end of follow-up ((51.9±16.5)% vs.(45.9±12.8)%, P=0.036). However, no significant change was observed as for percent plaque volume ((49.1±13.7)% vs.(47.5±14.9)%, P=0.554) in the statin lowering LDL-C <50% group. Percent plaque volume was significantly reduced by the end of follow-up ((39.1±17.1)% vs.(48.2±15.0)%, P=0.003) in the statin lowering LDL-C ≥50% group. Multivariable linear regression analysis showed that both higher baseline total plaque volume(β=-0.50, P<0.001) and statin lowering LDL-C ≥50%(β=-0.32, P=0.001) were independent determinants of plaque regression.

CONCLUSION

This study suggests that LDL-C reduction ≥50% post statin treatment can retard plaque progression, and even induce regression of mild non-calcified coronary plaque, patients with greater baseline coronary plaque volume are more likely to benefit from statin therapy.

Authors+Show Affiliations

Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

27346264

Citation

Li, Z N., et al. "[Effects of Statin Intervention On Mild Coronary Plaque Progression Assessed By Serial Coronary CT Angiography]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 44, no. 6, 2016, pp. 508-12.
Li ZN, Hou ZH, Liu K, et al. [Effects of statin intervention on mild coronary plaque progression assessed by serial coronary CT angiography]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016;44(6):508-12.
Li, Z. N., Hou, Z. H., Liu, K., Wang, Z. Q., Yin, W. H., Gao, Y., Xu, H. Y., Jiang, S. L., & Lyu, B. (2016). [Effects of statin intervention on mild coronary plaque progression assessed by serial coronary CT angiography]. Zhonghua Xin Xue Guan Bing Za Zhi, 44(6), 508-12. https://doi.org/10.3760/cma.j.issn.0253-3758.2016.06.010
Li ZN, et al. [Effects of Statin Intervention On Mild Coronary Plaque Progression Assessed By Serial Coronary CT Angiography]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jun 24;44(6):508-12. PubMed PMID: 27346264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of statin intervention on mild coronary plaque progression assessed by serial coronary CT angiography]. AU - Li,Z N, AU - Hou,Z H, AU - Liu,K, AU - Wang,Z Q, AU - Yin,W H, AU - Gao,Y, AU - Xu,H Y, AU - Jiang,S L, AU - Lyu,B, PY - 2016/6/28/entrez PY - 2016/6/28/pubmed PY - 2016/12/17/medline SP - 508 EP - 12 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 44 IS - 6 N2 - OBJECTIVE: To assess the effects of statin treatment on mild coronary plaque progression by serial coronary CT angiography. METHODS: A total of 120 consecutive patients (74 men, ages(58.9±8.1)years) with mild (≤50%luminal narrowing and lesion length<20 mm) non-calcified plaque detected by coronary CT angiography during September 2012 and December 2013 were prospectively enrolled in this study.Subjects were divided into three groups: no statin (n=36), statin lowering LDL-C <50% (n=43), and statin lowering LDL-C ≥50%(n=41). Serial scans were performed after a median interval of 705 (interquartile range: 467, 803) days.Total plaque volume, percent plaque volume for both baseline and follow-up were measured.Baseline and follow-up data were compared. RESULTS: Compared with baseline, total plaque volume in no statin group showed increasing trend by the end of follow-up ((97.3±57.8) mm(3) vs. (82.2±57.7) mm(3,) P=0.075). However, no significant change was observed as for total plaque volume ((78.5±45.2) mm(3) vs.(77.6±50.5) mm(3), P=0.910) in the statin lowering LDL-C <50% group.Total plaque volume was significantly reduced by the end of follow-up ((61.5 ± 46.1) mm(3) vs.(77.7±48.1) mm(3), P=0.024) in the statin lowering LDL-C ≥50% group.Percent plaque volume in no statin group was significantly increased by the end of follow-up ((51.9±16.5)% vs.(45.9±12.8)%, P=0.036). However, no significant change was observed as for percent plaque volume ((49.1±13.7)% vs.(47.5±14.9)%, P=0.554) in the statin lowering LDL-C <50% group. Percent plaque volume was significantly reduced by the end of follow-up ((39.1±17.1)% vs.(48.2±15.0)%, P=0.003) in the statin lowering LDL-C ≥50% group. Multivariable linear regression analysis showed that both higher baseline total plaque volume(β=-0.50, P<0.001) and statin lowering LDL-C ≥50%(β=-0.32, P=0.001) were independent determinants of plaque regression. CONCLUSION: This study suggests that LDL-C reduction ≥50% post statin treatment can retard plaque progression, and even induce regression of mild non-calcified coronary plaque, patients with greater baseline coronary plaque volume are more likely to benefit from statin therapy. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/27346264/[Effects_of_statin_intervention_on_mild_coronary_plaque_progression_assessed_by_serial_coronary_CT_angiography]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2016&amp;vol=44&amp;issue=6&amp;fpage=508 DB - PRIME DP - Unbound Medicine ER -