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Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats.
Brain Res Bull. 2016 07; 125:134-43.BR

Abstract

Chronic stress occurs in everyday life and induces depression-like behaviors, associated with proteins alterations and apoptosis in brain. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The aim of this study was to determine whether resveratrol administration influences chronic restraint stress (CRS) - induced depression-like behaviors and explores underlying mechanisms. Male Wistar rats were subjected to CRS protocol for a period of 3 weeks to induce depressive-like behavior. The results showed that resveratrol (80mg/kg/i.p) administrated for 3 weeks significantly reversed the CRS-induced behavioral abnormalities (reduced sucrose preference and increased immobility time) in stressed rats. CRS exposure significantly decreased BDNF levels and phosphorylation of extracellular signal-regulated kinase (pERK) in hippocampus and prefrontal cortex (PFC), accompanied by decreased Bcl-2 mRNA expression and increased Bax mRNA expression, while resveratrol treatment normalized these levels. All of these effects of resveratrol were essentially identical to that observed with fluoxetine. In conclusion, our studies showed that resveratrol exerted antidepressant-like effects in CRS rats, mediated in part by the apoptotic machinery and up-regulating BDNF and pERK levels in the brain region.

Authors+Show Affiliations

Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Ultrasound, Qilu hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: liudexiang@sdu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27346276

Citation

Wang, Xueer, et al. "Resveratrol Reverses Chronic Restraint Stress-induced Depression-like Behaviour: Involvement of BDNF Level, ERK Phosphorylation and Expression of Bcl-2 and Bax in Rats." Brain Research Bulletin, vol. 125, 2016, pp. 134-43.
Wang X, Xie Y, Zhang T, et al. Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats. Brain Res Bull. 2016;125:134-43.
Wang, X., Xie, Y., Zhang, T., Bo, S., Bai, X., Liu, H., Li, T., Liu, S., Zhou, Y., Cong, X., Wang, Z., & Liu, D. (2016). Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats. Brain Research Bulletin, 125, 134-43. https://doi.org/10.1016/j.brainresbull.2016.06.014
Wang X, et al. Resveratrol Reverses Chronic Restraint Stress-induced Depression-like Behaviour: Involvement of BDNF Level, ERK Phosphorylation and Expression of Bcl-2 and Bax in Rats. Brain Res Bull. 2016;125:134-43. PubMed PMID: 27346276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats. AU - Wang,Xueer, AU - Xie,Yunkai, AU - Zhang,Tiantian, AU - Bo,Shishi, AU - Bai,Xuemei, AU - Liu,Hansen, AU - Li,Tong, AU - Liu,Song, AU - Zhou,Yaru, AU - Cong,Xiang, AU - Wang,Zhen, AU - Liu,Dexiang, Y1 - 2016/06/23/ PY - 2016/04/19/received PY - 2016/06/21/revised PY - 2016/06/23/accepted PY - 2016/6/28/entrez PY - 2016/6/28/pubmed PY - 2017/10/31/medline KW - BDNF KW - Chronic restraint stress (CRS) KW - Depression KW - ERK KW - Resveratrol SP - 134 EP - 43 JF - Brain research bulletin JO - Brain Res. Bull. VL - 125 N2 - Chronic stress occurs in everyday life and induces depression-like behaviors, associated with proteins alterations and apoptosis in brain. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The aim of this study was to determine whether resveratrol administration influences chronic restraint stress (CRS) - induced depression-like behaviors and explores underlying mechanisms. Male Wistar rats were subjected to CRS protocol for a period of 3 weeks to induce depressive-like behavior. The results showed that resveratrol (80mg/kg/i.p) administrated for 3 weeks significantly reversed the CRS-induced behavioral abnormalities (reduced sucrose preference and increased immobility time) in stressed rats. CRS exposure significantly decreased BDNF levels and phosphorylation of extracellular signal-regulated kinase (pERK) in hippocampus and prefrontal cortex (PFC), accompanied by decreased Bcl-2 mRNA expression and increased Bax mRNA expression, while resveratrol treatment normalized these levels. All of these effects of resveratrol were essentially identical to that observed with fluoxetine. In conclusion, our studies showed that resveratrol exerted antidepressant-like effects in CRS rats, mediated in part by the apoptotic machinery and up-regulating BDNF and pERK levels in the brain region. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/27346276/Resveratrol_reverses_chronic_restraint_stress_induced_depression_like_behaviour:_Involvement_of_BDNF_level_ERK_phosphorylation_and_expression_of_Bcl_2_and_Bax_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(16)30138-1 DB - PRIME DP - Unbound Medicine ER -