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Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor be used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children?
Urol J. 2016 Jun 28; 13(3):2690-6.UJ

Abstract

PURPOSE

We investigated the utility of urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels as non-invasive markers for diagnosis and evaluation of treatment efficacy in children with overactive bladder (OAB).

MATERIALS AND METHODS

This prospective study included 24 children with OAB and 30 healthy controls. At the time of diagnosis, micturition disorder symptom scores (MDSS) were determined, blood and urine samples were collected, and anticholinergic therapy was initiated. Clinical responses were evaluated, at the third and sixth month of treatment, by MDSS and urinary NGF, BDNF, and creatinine levels.

CONCLUSION

In conclusion, urine NGF/Cr and BDNF/Cr ratios may be useful markers for diagnosis of OAB. The BDNF/Cr ratio was found to be more significant in monitoring treatment response.&nbsp.

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Authors+Show Affiliations

Özdemir K
Department of Pediatric Nephrology, Ege University School of Medicine, İzmir 3500, Turkey.
Dinçel N
Department of Pediatric Nephrology, Pediatric Hematology Oncology Training and Research Hospital, Ankara 0600, Turkey.
Berdeli A
Department of Molecular Biology, Ege University School of Medicine, İzmir 3500, Turkey.
Mir S
Department of Pediatric Nephrology, Ege University School of Medicine, İzmir 3500, Turkey.

MeSH

AdolescentBiomarkersBrain-Derived Neurotrophic FactorChildChild, PreschoolFemaleFollow-Up StudiesHumansMaleNerve Growth FactorProspective StudiesUrinary Bladder, Overactive

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27351324

Citation

Özdemir, Kadriye, et al. "Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor Be Used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children?" Urology Journal, vol. 13, no. 3, 2016, pp. 2690-6.
Özdemir K, Dinçel N, Berdeli A, et al. Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor be used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children? Urol J. 2016;13(3):2690-6.
Özdemir, K., Dinçel, N., Berdeli, A., & Mir, S. (2016). Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor be used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children? Urology Journal, 13(3), 2690-6.
Özdemir K, et al. Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor Be Used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children. Urol J. 2016 Jun 28;13(3):2690-6. PubMed PMID: 27351324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Urinary Nerve Growth Factor and Brain-Derived Neurotrophic Factor be used in the Diagnosis and Follow-Up of Voiding Dysfunction in Children? AU - Özdemir,Kadriye, AU - Dinçel,Nida, AU - Berdeli,Afig, AU - Mir,Sevgi, Y1 - 2016/06/28/ PY - 2015/11/06/received PY - 2016/03/26/accepted PY - 2016/02/15/revised PY - 2016/6/29/entrez PY - 2016/6/29/pubmed PY - 2017/4/19/medline SP - 2690 EP - 6 JF - Urology journal JO - Urol J VL - 13 IS - 3 N2 - PURPOSE: We investigated the utility of urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels as non-invasive markers for diagnosis and evaluation of treatment efficacy in children with overactive bladder (OAB). MATERIALS AND METHODS: This prospective study included 24 children with OAB and 30 healthy controls. At the time of diagnosis, micturition disorder symptom scores (MDSS) were determined, blood and urine samples were collected, and anticholinergic therapy was initiated. Clinical responses were evaluated, at the third and sixth month of treatment, by MDSS and urinary NGF, BDNF, and creatinine levels. CONCLUSION: In conclusion, urine NGF/Cr and BDNF/Cr ratios may be useful markers for diagnosis of OAB. The BDNF/Cr ratio was found to be more significant in monitoring treatment response.&nbsp. SN - 1735-546X UR - https://www.unboundmedicine.com/medline/citation/27351324/Can_Urinary_Nerve_Growth_Factor_and_Brain_Derived_Neurotrophic_Factor_be_used_in_the_Diagnosis_and_Follow_Up_of_Voiding_Dysfunction_in_Children L2 - http://journals.sbmu.ac.ir/urolj/index.php/uj/article/view/3262 DB - PRIME DP - Unbound Medicine ER -