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Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins.
Cancer Causes Control 2016; 27(9):1049-58CC

Abstract

PURPOSE

Alcohol intake may be associated with cancer risk, but epidemiologic evidence for prostate cancer is inconsistent. We aimed to prospectively investigate the association between midlife alcohol intake and drinking patterns with future prostate cancer risk and mortality in a population-based cohort of Finnish twins.

METHODS

Data were drawn from the Older Finnish Twin Cohort and included 11,372 twins followed from 1981 to 2012. Alcohol consumption was assessed by questionnaires administered at two time points over follow-up. Over the study period, 601 incident cases of prostate cancer and 110 deaths from prostate cancer occurred. Cox regression was used to evaluate associations between weekly alcohol intake and binge drinking patterns with prostate cancer risk and prostate cancer-specific mortality. Within-pair co-twin analyses were performed to control for potential confounding by shared genetic and early environmental factors.

RESULTS

Compared to light drinkers (≤3 drinks/week; non-abstainers), heavy drinkers (>14 drinks/week) were at a 1.46-fold higher risk (HR 1.46; 95 % CI 1.12, 1.91) of prostate cancer, adjusting for important confounders. Among current drinkers, binge drinkers were at a significantly increased risk of prostate cancer (HR 1.28; 95 % CI 1.06, 1.55) compared to non-binge drinkers. Abstainers were at a 1.90-fold higher risk (HR 1.90; 95 % CI 1.04, 3.47) of prostate cancer-specific mortality compared to light drinkers, but no other significant associations for mortality were found. Co-twin analyses suggested that alcohol consumption may be associated with prostate cancer risk independent of early environmental and genetic factors.

CONCLUSION

Heavy regular alcohol consumption and binge drinking patterns may be associated with increased prostate cancer risk, while abstinence may be associated with increased risk of prostate cancer-specific mortality compared to light alcohol consumption.

Authors+Show Affiliations

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Department of Public Health, University of Helsinki, Mannerheimintie 172, P.O. Box 41, 00014, Helsinki, Finland.Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22, 00130, Helsinki, Finland. School of Health Sciences, University of Tampere, 33014, Tampere, Finland.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Department of Public Health, University of Helsinki, Mannerheimintie 172, P.O. Box 41, 00014, Helsinki, Finland. jaakko.kaprio@helsinki.fi. Department of Health, National Institute for Health and Welfare, Mannerheimintie 166, P.O. Box 30, 00300, Helsinki, Finland. jaakko.kaprio@helsinki.fi. Institute for Molecular Medicine (FIMM), University of Helsinki, Tukholmankatu 8, P.O. Box 20, 00014, Helsinki, Finland. jaakko.kaprio@helsinki.fi.

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

27351919

Citation

Dickerman, Barbra A., et al. "Alcohol Intake, Drinking Patterns, and Prostate Cancer Risk and Mortality: a 30-year Prospective Cohort Study of Finnish Twins." Cancer Causes & Control : CCC, vol. 27, no. 9, 2016, pp. 1049-58.
Dickerman BA, Markt SC, Koskenvuo M, et al. Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins. Cancer Causes Control. 2016;27(9):1049-58.
Dickerman, B. A., Markt, S. C., Koskenvuo, M., Pukkala, E., Mucci, L. A., & Kaprio, J. (2016). Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins. Cancer Causes & Control : CCC, 27(9), pp. 1049-58. doi:10.1007/s10552-016-0778-6.
Dickerman BA, et al. Alcohol Intake, Drinking Patterns, and Prostate Cancer Risk and Mortality: a 30-year Prospective Cohort Study of Finnish Twins. Cancer Causes Control. 2016;27(9):1049-58. PubMed PMID: 27351919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins. AU - Dickerman,Barbra A, AU - Markt,Sarah Coseo, AU - Koskenvuo,Markku, AU - Pukkala,Eero, AU - Mucci,Lorelei A, AU - Kaprio,Jaakko, Y1 - 2016/06/28/ PY - 2016/01/26/received PY - 2016/06/10/accepted PY - 2016/6/29/entrez PY - 2016/6/29/pubmed PY - 2017/7/1/medline KW - Alcohol KW - Binge drinking KW - Prospective cohort study KW - Prostate cancer KW - Twins SP - 1049 EP - 58 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 27 IS - 9 N2 - PURPOSE: Alcohol intake may be associated with cancer risk, but epidemiologic evidence for prostate cancer is inconsistent. We aimed to prospectively investigate the association between midlife alcohol intake and drinking patterns with future prostate cancer risk and mortality in a population-based cohort of Finnish twins. METHODS: Data were drawn from the Older Finnish Twin Cohort and included 11,372 twins followed from 1981 to 2012. Alcohol consumption was assessed by questionnaires administered at two time points over follow-up. Over the study period, 601 incident cases of prostate cancer and 110 deaths from prostate cancer occurred. Cox regression was used to evaluate associations between weekly alcohol intake and binge drinking patterns with prostate cancer risk and prostate cancer-specific mortality. Within-pair co-twin analyses were performed to control for potential confounding by shared genetic and early environmental factors. RESULTS: Compared to light drinkers (≤3 drinks/week; non-abstainers), heavy drinkers (>14 drinks/week) were at a 1.46-fold higher risk (HR 1.46; 95 % CI 1.12, 1.91) of prostate cancer, adjusting for important confounders. Among current drinkers, binge drinkers were at a significantly increased risk of prostate cancer (HR 1.28; 95 % CI 1.06, 1.55) compared to non-binge drinkers. Abstainers were at a 1.90-fold higher risk (HR 1.90; 95 % CI 1.04, 3.47) of prostate cancer-specific mortality compared to light drinkers, but no other significant associations for mortality were found. Co-twin analyses suggested that alcohol consumption may be associated with prostate cancer risk independent of early environmental and genetic factors. CONCLUSION: Heavy regular alcohol consumption and binge drinking patterns may be associated with increased prostate cancer risk, while abstinence may be associated with increased risk of prostate cancer-specific mortality compared to light alcohol consumption. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/27351919/Alcohol_intake_drinking_patterns_and_prostate_cancer_risk_and_mortality:_a_30_year_prospective_cohort_study_of_Finnish_twins_ L2 - https://doi.org/10.1007/s10552-016-0778-6 DB - PRIME DP - Unbound Medicine ER -