Tags

Type your tag names separated by a space and hit enter

Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis.
Reprod Toxicol. 2016 10; 65:59-66.RT

Abstract

Epidemiologic studies of in utero phthalate exposure and birth outcomes have had conflicting findings. The objective of this study was to characterize maternal phthalate exposure across pregnancy, examine associations between maternal phthalate levels and infant size and gestational age at birth, and investigate relationships between concurrent bisphenol A (BPA) and phthalate exposure and birth outcomes. Women in the Michigan Mother-Infant Pairs cohort provided urine and blood samples during their first trimester and at delivery. Urinary phthalate metabolites and serum BPA were measured at both time points, and birth weight, length, head circumference, and gestational age were recorded from medical records. Maternal DEHP metabolite concentrations were significantly higher at delivery compared to the first trimester (p<0.05), suggesting increased DEHP exposure late in pregnancy. A number of phthalate metabolites were associated with birth size and gestational age in patterns that varied by sex and timing of exposure, independent of BPA exposure.

Authors+Show Affiliations

Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

27352641

Citation

Watkins, Deborah J., et al. "Maternal Phthalate Exposure During Early Pregnancy and at Delivery in Relation to Gestational Age and Size at Birth: a Preliminary Analysis." Reproductive Toxicology (Elmsford, N.Y.), vol. 65, 2016, pp. 59-66.
Watkins DJ, Milewski S, Domino SE, et al. Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis. Reprod Toxicol. 2016;65:59-66.
Watkins, D. J., Milewski, S., Domino, S. E., Meeker, J. D., & Padmanabhan, V. (2016). Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis. Reproductive Toxicology (Elmsford, N.Y.), 65, 59-66. https://doi.org/10.1016/j.reprotox.2016.06.021
Watkins DJ, et al. Maternal Phthalate Exposure During Early Pregnancy and at Delivery in Relation to Gestational Age and Size at Birth: a Preliminary Analysis. Reprod Toxicol. 2016;65:59-66. PubMed PMID: 27352641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis. AU - Watkins,Deborah J, AU - Milewski,Samantha, AU - Domino,Steven E, AU - Meeker,John D, AU - Padmanabhan,Vasantha, Y1 - 2016/06/25/ PY - 2016/02/02/received PY - 2016/06/14/revised PY - 2016/06/24/accepted PY - 2016/6/30/pubmed PY - 2018/1/6/medline PY - 2016/6/30/entrez KW - Birth weight KW - Bisphenol A KW - Exposure KW - Gestational age KW - In utero KW - Phthalates SP - 59 EP - 66 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod Toxicol VL - 65 N2 - Epidemiologic studies of in utero phthalate exposure and birth outcomes have had conflicting findings. The objective of this study was to characterize maternal phthalate exposure across pregnancy, examine associations between maternal phthalate levels and infant size and gestational age at birth, and investigate relationships between concurrent bisphenol A (BPA) and phthalate exposure and birth outcomes. Women in the Michigan Mother-Infant Pairs cohort provided urine and blood samples during their first trimester and at delivery. Urinary phthalate metabolites and serum BPA were measured at both time points, and birth weight, length, head circumference, and gestational age were recorded from medical records. Maternal DEHP metabolite concentrations were significantly higher at delivery compared to the first trimester (p<0.05), suggesting increased DEHP exposure late in pregnancy. A number of phthalate metabolites were associated with birth size and gestational age in patterns that varied by sex and timing of exposure, independent of BPA exposure. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/27352641/Maternal_phthalate_exposure_during_early_pregnancy_and_at_delivery_in_relation_to_gestational_age_and_size_at_birth:_A_preliminary_analysis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27352641/ DB - PRIME DP - Unbound Medicine ER -