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Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis.

Abstract

We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.

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  • Authors+Show Affiliations

    ,

    a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;

    ,

    a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;

    ,

    a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;

    ,

    a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;

    ,

    b Department of Epidemiology and Health Statistics , Zhejiang University School of Public Health , Hangzhou , China.

    a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;

    Source

    MeSH

    Antioxidants
    Ascorbic Acid
    Beta-Cryptoxanthin
    Carotenoids
    Databases, Factual
    Diet
    Humans
    Lutein
    Lycopene
    Pancreatic Neoplasms
    Risk Factors
    Selenium
    Vitamin E
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    27356952

    Citation

    Chen, Jiamin, et al. "Association Between Intake of Antioxidants and Pancreatic Cancer Risk: a Meta-analysis." International Journal of Food Sciences and Nutrition, vol. 67, no. 7, 2016, pp. 744-53.
    Chen J, Jiang W, Shao L, et al. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Int J Food Sci Nutr. 2016;67(7):744-53.
    Chen, J., Jiang, W., Shao, L., Zhong, D., Wu, Y., & Cai, J. (2016). Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. International Journal of Food Sciences and Nutrition, 67(7), pp. 744-53. doi:10.1080/09637486.2016.1197892.
    Chen J, et al. Association Between Intake of Antioxidants and Pancreatic Cancer Risk: a Meta-analysis. Int J Food Sci Nutr. 2016;67(7):744-53. PubMed PMID: 27356952.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. AU - Chen,Jiamin, AU - Jiang,Wuxia, AU - Shao,Liming, AU - Zhong,Dandan, AU - Wu,Yihua, AU - Cai,Jianting, Y1 - 2016/06/30/ PY - 2016/7/1/entrez PY - 2016/7/1/pubmed PY - 2017/4/22/medline KW - Antioxidant KW - association KW - intake KW - pancreatic cancer KW - risk SP - 744 EP - 53 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 67 IS - 7 N2 - We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/27356952/Association_between_intake_of_antioxidants_and_pancreatic_cancer_risk:_a_meta_analysis_ L2 - http://www.tandfonline.com/doi/full/10.1080/09637486.2016.1197892 DB - PRIME DP - Unbound Medicine ER -