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Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts.
Asian Pac J Allergy Immunol. 2017 Mar; 35(1):60-65.AP

Abstract

BACKGROUND

Skin prick test (SPT) and specific IgE (sIgE) are approved for evaluation of allergen sensitization. Local allergen extracts are less expensive and more available but need to be standardized.

OBJECTIVE

To compare SPT results of local and imported allergen extracts and sIgE levels in response to the American cockroach, dog, cat, Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df) and Cladosporium spp. allergens.

METHOD

This prospective, randomized, double-blind, self-controlled study was performed in respiratory allergic volunteers. Each subject was pricked with local and imported allergen extracts and sIgE levels were measured.

RESULTS

The agreement between SPT results from each local and imported allergen extract was statistically significant, and the level of agreement for dog allergens was very good (kappa > 0.8). All patients with a positive SPT in response to imported Dp allergen extract had positive SPT in response to local Dp allergen extract. Mean wheal diameter of each allergen in both groups showed significant correlation with sIgE levels. The correlation coefficient (CC) for cat allergens showed a very good-to-excellent relationship (CC> 0.75). When compared with sIgE levels, SPT results for imported and local allergen extracts showed comparable sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio (LR)+ and LR-.

CONCLUSIONS

When the SPT results are compared between local and imported allergen extracts, all were found to have significant agreement, with very good agreement for cat allergens. When the SPT results are compared with specific IgE levels, both local and imported allergen extract provided comparable validity.

Authors+Show Affiliations

Division of Allergy and Immunology, Department of Pediatrics.Division of Allergy and Immunology, Department of Pediatrics.Department of Oto-rhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700.Division of Allergy and Immunology, Department of Pediatrics.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27362401

Citation

Visitsunthorn, Nualanong, et al. "Comparison Between Specific IgE Levels and Skin Prick Test Results of Local and Imported American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts." Asian Pacific Journal of Allergy and Immunology, vol. 35, no. 1, 2017, pp. 60-65.
Visitsunthorn N, Sripramong C, Bunnag C, et al. Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts. Asian Pac J Allergy Immunol. 2017;35(1):60-65.
Visitsunthorn, N., Sripramong, C., Bunnag, C., & Jirapongsananuruk, O. (2017). Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts. Asian Pacific Journal of Allergy and Immunology, 35(1), 60-65. https://doi.org/10.12932/AP0745
Visitsunthorn N, et al. Comparison Between Specific IgE Levels and Skin Prick Test Results of Local and Imported American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts. Asian Pac J Allergy Immunol. 2017;35(1):60-65. PubMed PMID: 27362401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts. AU - Visitsunthorn,Nualanong, AU - Sripramong,Chaweewan, AU - Bunnag,Chaweewan, AU - Jirapongsananuruk,Orathai, PY - 2016/7/1/pubmed PY - 2017/6/24/medline PY - 2016/7/1/entrez SP - 60 EP - 65 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac. J. Allergy Immunol. VL - 35 IS - 1 N2 - BACKGROUND: Skin prick test (SPT) and specific IgE (sIgE) are approved for evaluation of allergen sensitization. Local allergen extracts are less expensive and more available but need to be standardized. OBJECTIVE: To compare SPT results of local and imported allergen extracts and sIgE levels in response to the American cockroach, dog, cat, Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df) and Cladosporium spp. allergens. METHOD: This prospective, randomized, double-blind, self-controlled study was performed in respiratory allergic volunteers. Each subject was pricked with local and imported allergen extracts and sIgE levels were measured. RESULTS: The agreement between SPT results from each local and imported allergen extract was statistically significant, and the level of agreement for dog allergens was very good (kappa > 0.8). All patients with a positive SPT in response to imported Dp allergen extract had positive SPT in response to local Dp allergen extract. Mean wheal diameter of each allergen in both groups showed significant correlation with sIgE levels. The correlation coefficient (CC) for cat allergens showed a very good-to-excellent relationship (CC> 0.75). When compared with sIgE levels, SPT results for imported and local allergen extracts showed comparable sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio (LR)+ and LR-. CONCLUSIONS: When the SPT results are compared between local and imported allergen extracts, all were found to have significant agreement, with very good agreement for cat allergens. When the SPT results are compared with specific IgE levels, both local and imported allergen extract provided comparable validity. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/27362401/Comparison_between_specific_IgE_levels_and_skin_prick_test_results_of_local_and_imported_American_cockroach_dog_cat_dust_mites_and_mold_allergen_extracts_ L2 - http://apjai-journal.org/wp-content/uploads/2017/04/V35No1_10.-AP0745.pdf DB - PRIME DP - Unbound Medicine ER -