Tags

Type your tag names separated by a space and hit enter

Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer.
J Forensic Sci. 2016 09; 61(5):1208-14.JF

Abstract

This is the first report on development of a library search-based screening system for 3,4-methylenedioxymethamphetamine (MDMA) in ecstasy tablets using a portable near-infrared (NIR) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride (MDMA-HCl) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA-HCl and diluents were used to decide criteria to judge MDMA-positive or MDMA-negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty-two of 27 MDMA tablets were truly judged as MDMA-positive. Five false-negative results may be caused by compounds not included in the library. No false-positive results were obtained for medicinal tablets. This system will be a useful tool for on-site screening of MDMA tablets.

Authors+Show Affiliations

National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan. tujikawa@nrips.go.jp.National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobegakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8586, Japan.Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobegakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8586, Japan.National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27362667

Citation

Tsujikawa, Kenji, et al. "Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer." Journal of Forensic Sciences, vol. 61, no. 5, 2016, pp. 1208-14.
Tsujikawa K, Yamamuro T, Kuwayama K, et al. Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer. J Forensic Sci. 2016;61(5):1208-14.
Tsujikawa, K., Yamamuro, T., Kuwayama, K., Kanamori, T., Iwata, Y. T., Miyamoto, K., Kasuya, F., & Inoue, H. (2016). Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer. Journal of Forensic Sciences, 61(5), 1208-14. https://doi.org/10.1111/1556-4029.13122
Tsujikawa K, et al. Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer. J Forensic Sci. 2016;61(5):1208-14. PubMed PMID: 27362667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a Library Search-Based Screening System for 3,4-Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer. AU - Tsujikawa,Kenji, AU - Yamamuro,Tadashi, AU - Kuwayama,Kenji, AU - Kanamori,Tatsuyuki, AU - Iwata,Yuko T, AU - Miyamoto,Kazuna, AU - Kasuya,Fumiyo, AU - Inoue,Hiroyuki, Y1 - 2016/06/30/ PY - 2015/03/30/received PY - 2015/11/01/revised PY - 2015/11/14/accepted PY - 2016/7/1/entrez PY - 2016/7/1/pubmed PY - 2018/3/10/medline KW - 3,4-methylenedioxymethamphetamine KW - ecstasy KW - forensic science KW - library search KW - near-infrared spectrometry KW - on-site screening SP - 1208 EP - 14 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 61 IS - 5 N2 - This is the first report on development of a library search-based screening system for 3,4-methylenedioxymethamphetamine (MDMA) in ecstasy tablets using a portable near-infrared (NIR) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride (MDMA-HCl) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA-HCl and diluents were used to decide criteria to judge MDMA-positive or MDMA-negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty-two of 27 MDMA tablets were truly judged as MDMA-positive. Five false-negative results may be caused by compounds not included in the library. No false-positive results were obtained for medicinal tablets. This system will be a useful tool for on-site screening of MDMA tablets. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/27362667/Development_of_a_Library_Search_Based_Screening_System_for_34_Methylenedioxymethamphetamine_in_Ecstasy_Tablets_Using_a_Portable_Near_Infrared_Spectrometer_ L2 - https://doi.org/10.1111/1556-4029.13122 DB - PRIME DP - Unbound Medicine ER -