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Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls.
Am J Psychiatry. 2016 Dec 01; 173(12):1223-1230.AJ

Abstract

OBJECTIVE

A blunted neural response to rewards has recently emerged as a potential mechanistic biomarker of adolescent depression. The reward positivity, an event-related potential elicited by feedback indicating monetary gain relative to loss, has been associated with risk for depression. The authors examined whether the reward positivity prospectively predicted the development of depression 18 months later in a large community sample of adolescent girls.

METHOD

The sample included 444 girls 13.5-15.5 years old with no lifetime history of a depressive disorder, along with a biological parent for each girl. At baseline, the adolescents' reward positivity was measured using a monetary guessing task, their current depressive symptoms were assessed using a self-report questionnaire, and the adolescents' and parents' lifetime psychiatric histories were evaluated with diagnostic interviews. The same interview and questionnaire were administered to the adolescents again approximately 18 months later.

RESULTS

A blunted reward positivity at baseline predicted first-onset depressive disorder and greater depressive symptom scores 18 months later. The reward positivity was also a significant predictor independent of other prominent risk factors, including baseline depressive symptoms and adolescent and parental lifetime psychiatric history. The combination of a blunted reward positivity and greater depressive symptom scores at baseline provided the greatest positive predictive value for first-onset depressive disorder.

CONCLUSIONS

This study provides strong converging evidence that a blunted neural response to rewards precedes adolescent-onset depression and symptom emergence. Blunted neural response may therefore constitute an important target for screening and prevention.

Authors+Show Affiliations

From the Departments of Psychology and Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, N.Y.From the Departments of Psychology and Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, N.Y.From the Departments of Psychology and Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, N.Y.From the Departments of Psychology and Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, N.Y.From the Departments of Psychology and Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, N.Y.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27363510

Citation

Nelson, Brady D., et al. "Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls." The American Journal of Psychiatry, vol. 173, no. 12, 2016, pp. 1223-1230.
Nelson BD, Perlman G, Klein DN, et al. Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls. Am J Psychiatry. 2016;173(12):1223-1230.
Nelson, B. D., Perlman, G., Klein, D. N., Kotov, R., & Hajcak, G. (2016). Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls. The American Journal of Psychiatry, 173(12), 1223-1230.
Nelson BD, et al. Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls. Am J Psychiatry. 2016 Dec 1;173(12):1223-1230. PubMed PMID: 27363510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls. AU - Nelson,Brady D, AU - Perlman,Greg, AU - Klein,Daniel N, AU - Kotov,Roman, AU - Hajcak,Greg, Y1 - 2016/07/01/ PY - 2016/7/2/pubmed PY - 2017/5/2/medline PY - 2016/7/2/entrez SP - 1223 EP - 1230 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 173 IS - 12 N2 - OBJECTIVE: A blunted neural response to rewards has recently emerged as a potential mechanistic biomarker of adolescent depression. The reward positivity, an event-related potential elicited by feedback indicating monetary gain relative to loss, has been associated with risk for depression. The authors examined whether the reward positivity prospectively predicted the development of depression 18 months later in a large community sample of adolescent girls. METHOD: The sample included 444 girls 13.5-15.5 years old with no lifetime history of a depressive disorder, along with a biological parent for each girl. At baseline, the adolescents' reward positivity was measured using a monetary guessing task, their current depressive symptoms were assessed using a self-report questionnaire, and the adolescents' and parents' lifetime psychiatric histories were evaluated with diagnostic interviews. The same interview and questionnaire were administered to the adolescents again approximately 18 months later. RESULTS: A blunted reward positivity at baseline predicted first-onset depressive disorder and greater depressive symptom scores 18 months later. The reward positivity was also a significant predictor independent of other prominent risk factors, including baseline depressive symptoms and adolescent and parental lifetime psychiatric history. The combination of a blunted reward positivity and greater depressive symptom scores at baseline provided the greatest positive predictive value for first-onset depressive disorder. CONCLUSIONS: This study provides strong converging evidence that a blunted neural response to rewards precedes adolescent-onset depression and symptom emergence. Blunted neural response may therefore constitute an important target for screening and prevention. SN - 1535-7228 UR - https://www.unboundmedicine.com/medline/citation/27363510/Blunted_Neural_Response_to_Rewards_as_a_Prospective_Predictor_of_the_Development_of_Depression_in_Adolescent_Girls_ L2 - https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2016.15121524?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -