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Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas.
Cancer Res. 1989 Jul 15; 49(14):4024-9.CR

Abstract

Data from case-control studies of respiratory cancer conducted in the Texas Gulf Coast region between 1975 and 1980 were used to examine the effects of smoking and alcohol on laryngeal cancer risk. Analyses were limited to living white males, aged 30-79, which included 151 histologically confirmed incident laryngeal cancer cases and 235 population-based controls. A dose-dependent effect for cigarette smoking was observed, with odds ratios ranging from 4.4 for ever smoking up to one-half pack daily, to 10.4 for smoking more than two packs per day. Risks were strongest for current smokers and declined markedly following smoking cessation. Higher risks were associated with smoking nonfiltered than filtered cigarettes. No significantly elevated risks were associated with the use of other tobacco products. Odds ratios for alcohol beverages did not increase linearly with increasing use; instead risks were twofold for consumption of four or more drinks weekly. Patterns of risk associated with beer and hard liquor were not consistent and few participants drank wine. Although the data were sparse, a dose-response effect for alcohol intake was suggested for tumors of the supraglottis (n = 23), while for nonsupraglottic cases, alcohol risks were elevated but did not increase beyond those observed for four drinks per week. Predicted risks for the combined effects of cigarette and alcohol use were intermediate between an additive and multiplicative form of interaction.

Authors+Show Affiliations

Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2736543

Citation

Falk, R T., et al. "Effect of Smoking and Alcohol Consumption On Laryngeal Cancer Risk in Coastal Texas." Cancer Research, vol. 49, no. 14, 1989, pp. 4024-9.
Falk RT, Pickle LW, Brown LM, et al. Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. Cancer Res. 1989;49(14):4024-9.
Falk, R. T., Pickle, L. W., Brown, L. M., Mason, T. J., Buffler, P. A., & Fraumeni, J. F. (1989). Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. Cancer Research, 49(14), 4024-9.
Falk RT, et al. Effect of Smoking and Alcohol Consumption On Laryngeal Cancer Risk in Coastal Texas. Cancer Res. 1989 Jul 15;49(14):4024-9. PubMed PMID: 2736543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. AU - Falk,R T, AU - Pickle,L W, AU - Brown,L M, AU - Mason,T J, AU - Buffler,P A, AU - Fraumeni,J F,Jr PY - 1989/7/15/pubmed PY - 2001/3/28/medline PY - 1989/7/15/entrez SP - 4024 EP - 9 JF - Cancer research JO - Cancer Res. VL - 49 IS - 14 N2 - Data from case-control studies of respiratory cancer conducted in the Texas Gulf Coast region between 1975 and 1980 were used to examine the effects of smoking and alcohol on laryngeal cancer risk. Analyses were limited to living white males, aged 30-79, which included 151 histologically confirmed incident laryngeal cancer cases and 235 population-based controls. A dose-dependent effect for cigarette smoking was observed, with odds ratios ranging from 4.4 for ever smoking up to one-half pack daily, to 10.4 for smoking more than two packs per day. Risks were strongest for current smokers and declined markedly following smoking cessation. Higher risks were associated with smoking nonfiltered than filtered cigarettes. No significantly elevated risks were associated with the use of other tobacco products. Odds ratios for alcohol beverages did not increase linearly with increasing use; instead risks were twofold for consumption of four or more drinks weekly. Patterns of risk associated with beer and hard liquor were not consistent and few participants drank wine. Although the data were sparse, a dose-response effect for alcohol intake was suggested for tumors of the supraglottis (n = 23), while for nonsupraglottic cases, alcohol risks were elevated but did not increase beyond those observed for four drinks per week. Predicted risks for the combined effects of cigarette and alcohol use were intermediate between an additive and multiplicative form of interaction. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2736543/Effect_of_smoking_and_alcohol_consumption_on_laryngeal_cancer_risk_in_coastal_Texas_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2736543 DB - PRIME DP - Unbound Medicine ER -