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Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group.
Cancer Res. 1989 Jul 15; 49(14):4030-7.CR

Abstract

The Childrens Cancer Study Group conducted a case-control study of occupational exposures of parents of 204 children (under 18 yr of age) with acute nonlymphoblastic leukemia. The most consistent finding was an association of acute nonlymphoblastic leukemia risk with pesticide exposure. Controls matched by date of birth and race were obtained through random digit dialing. Odds ratio (OR) for paternal pesticide exposure in jobs held for longer than 1000 days was 2.7 (95% confidence interval, 1.0 to 7.0; trend, P = 0.06), and seven case mothers and no control mothers had prolonged exposure (trend, P = 0.008). Risk estimates for parental pesticide exposure were substantially increased for children under age 6 at diagnosis (OR for prolonged exposure to either parent = 11.4; trend, P = 0.003) and for those with myelomonocytic and monocytic subtypes (OR, 13.6; trend, P = 0.007). Moreover, there were significantly elevated risks for direct exposure of the child to pesticides in the household (OR for exposure most days = 3.5; trend, P = 0.04) and for maternal exposure to household pesticides at the time of pregnancy (eight case mothers versus no controls for exposure most days; trend, P = 0.05). Paternal exposures to solvents (OR, 2.1; P = 0.003) and petroleum products (OR, 2.4; P = 0.002) were reported more commonly for cases than controls. Other occupational exposures reported significantly more often by case parents were paternal exposure to plastics or lead and maternal exposure to paints and pigments, metal dusts, and sawdust. These data provide further evidence for a role of occupational risk factors in the etiology of childhood cancer.

Authors+Show Affiliations

School of Medicine, University of Southern California, Los Angeles 90089.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2736544

Citation

Buckley, J D., et al. "Occupational Exposures of Parents of Children With Acute Nonlymphocytic Leukemia: a Report From the Childrens Cancer Study Group." Cancer Research, vol. 49, no. 14, 1989, pp. 4030-7.
Buckley JD, Robison LL, Swotinsky R, et al. Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Res. 1989;49(14):4030-7.
Buckley, J. D., Robison, L. L., Swotinsky, R., Garabrant, D. H., LeBeau, M., Manchester, P., Nesbit, M. E., Odom, L., Peters, J. M., & Woods, W. G. (1989). Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Research, 49(14), 4030-7.
Buckley JD, et al. Occupational Exposures of Parents of Children With Acute Nonlymphocytic Leukemia: a Report From the Childrens Cancer Study Group. Cancer Res. 1989 Jul 15;49(14):4030-7. PubMed PMID: 2736544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. A1 - Buckley,J D, AU - Robison,L L, AU - Swotinsky,R, AU - Garabrant,D H, AU - LeBeau,M, AU - Manchester,P, AU - Nesbit,M E, AU - Odom,L, AU - Peters,J M, AU - Woods,W G, PY - 1989/7/15/pubmed PY - 1989/7/15/medline PY - 1989/7/15/entrez SP - 4030 EP - 7 JF - Cancer research JO - Cancer Res VL - 49 IS - 14 N2 - The Childrens Cancer Study Group conducted a case-control study of occupational exposures of parents of 204 children (under 18 yr of age) with acute nonlymphoblastic leukemia. The most consistent finding was an association of acute nonlymphoblastic leukemia risk with pesticide exposure. Controls matched by date of birth and race were obtained through random digit dialing. Odds ratio (OR) for paternal pesticide exposure in jobs held for longer than 1000 days was 2.7 (95% confidence interval, 1.0 to 7.0; trend, P = 0.06), and seven case mothers and no control mothers had prolonged exposure (trend, P = 0.008). Risk estimates for parental pesticide exposure were substantially increased for children under age 6 at diagnosis (OR for prolonged exposure to either parent = 11.4; trend, P = 0.003) and for those with myelomonocytic and monocytic subtypes (OR, 13.6; trend, P = 0.007). Moreover, there were significantly elevated risks for direct exposure of the child to pesticides in the household (OR for exposure most days = 3.5; trend, P = 0.04) and for maternal exposure to household pesticides at the time of pregnancy (eight case mothers versus no controls for exposure most days; trend, P = 0.05). Paternal exposures to solvents (OR, 2.1; P = 0.003) and petroleum products (OR, 2.4; P = 0.002) were reported more commonly for cases than controls. Other occupational exposures reported significantly more often by case parents were paternal exposure to plastics or lead and maternal exposure to paints and pigments, metal dusts, and sawdust. These data provide further evidence for a role of occupational risk factors in the etiology of childhood cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2736544/Occupational_exposures_of_parents_of_children_with_acute_nonlymphocytic_leukemia:_a_report_from_the_Childrens_Cancer_Study_Group_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2736544 DB - PRIME DP - Unbound Medicine ER -