Tags

Type your tag names separated by a space and hit enter

Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study.
Psychiatry Res 2016; 243:49-52PR

Abstract

Elderly stroke survivors are at risk of malnutrition and long-term cognitive impairment. Vitamin B-related metabolites, folate and methylmalonic acid, have been implicated in cognitive function. We conducted a study exploring the relationship between blood folate, methylmalonic acid and post-stroke cognitive impairment. This is a cross sectional study of elderly Swedish patients (n=149) 20 months post-stroke, assessed using the Mini Mental State Examination, serum blood levels of methylmalonic acid and red blood cell levels of folate. Linear modeling indicated that low levels of blood folate and elevated methylmalonic acid significantly contributed to cognitive impairment in stroke survivors. Half of the stroke survivors were shown to have folate deficiency at 20 months after stroke. Folate deficiency is common long term after stroke and both low folate and elevated methylmalonic acid appear to be associated with long term cognitive impairment, in elderly Swedish stroke survivors.

Authors+Show Affiliations

Centre for the Heart and Mind, Australian Catholic University, Level 5, 215 Spring Street, Melbourne, VIC 3000, Australia; Mental Health Service, St. Vincent's Hospital, Melbourne, VIC, Australia. Electronic address: Michaela.pascoe@acu.edu.au.Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27367490

Citation

Pascoe, Michaela C., and Thomas Linden. "Folate and MMA Predict Cognitive Impairment in Elderly Stroke Survivors: a Cross Sectional Study." Psychiatry Research, vol. 243, 2016, pp. 49-52.
Pascoe MC, Linden T. Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study. Psychiatry Res. 2016;243:49-52.
Pascoe, M. C., & Linden, T. (2016). Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study. Psychiatry Research, 243, pp. 49-52. doi:10.1016/j.psychres.2016.06.008.
Pascoe MC, Linden T. Folate and MMA Predict Cognitive Impairment in Elderly Stroke Survivors: a Cross Sectional Study. Psychiatry Res. 2016 Sep 30;243:49-52. PubMed PMID: 27367490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study. AU - Pascoe,Michaela C, AU - Linden,Thomas, Y1 - 2016/06/16/ PY - 2015/11/24/received PY - 2016/06/06/revised PY - 2016/06/09/accepted PY - 2016/7/2/entrez PY - 2016/7/2/pubmed PY - 2017/11/1/medline KW - Cognition KW - Geriatric KW - Ischemia KW - Nutrition SP - 49 EP - 52 JF - Psychiatry research JO - Psychiatry Res VL - 243 N2 - Elderly stroke survivors are at risk of malnutrition and long-term cognitive impairment. Vitamin B-related metabolites, folate and methylmalonic acid, have been implicated in cognitive function. We conducted a study exploring the relationship between blood folate, methylmalonic acid and post-stroke cognitive impairment. This is a cross sectional study of elderly Swedish patients (n=149) 20 months post-stroke, assessed using the Mini Mental State Examination, serum blood levels of methylmalonic acid and red blood cell levels of folate. Linear modeling indicated that low levels of blood folate and elevated methylmalonic acid significantly contributed to cognitive impairment in stroke survivors. Half of the stroke survivors were shown to have folate deficiency at 20 months after stroke. Folate deficiency is common long term after stroke and both low folate and elevated methylmalonic acid appear to be associated with long term cognitive impairment, in elderly Swedish stroke survivors. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/27367490/Folate_and_MMA_predict_cognitive_impairment_in_elderly_stroke_survivors:_A_cross_sectional_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(15)30729-0 DB - PRIME DP - Unbound Medicine ER -