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Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT.
Fitoterapia. 2016 Sep; 113:1-5.F

Abstract

Allopurinol is a commonly used medication to treat hyperuricemia and its complications. Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to enhanced hypouricemic effect of allopurinol based on uric acid metabolism enzyme XOD. In this study, we evaluated whether Pallidifloside D (5mg/kg) enhanced hypouricemic effect of allopurinol (5mg/kg) related to others uric acid metabolism enzymes such as PRPS, HGPRT and PRPPAT. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly up-regulated HGPRT mRNA expression and down-regulated the mRNA expression of PRPS and PRPPAT in PC12 cells (all P<0.01). These results strongly suggest that hypouricemic effect of allopurinol are improved by Pallidifloside D via numerous mechanisms and our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.

Authors+Show Affiliations

Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China.Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China; Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: longhui804@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27370097

Citation

Li, Hong-Gang, et al. "Hypouricemic Effect of Allopurinol Are Improved By Pallidifloside D Based On the Uric Acid Metabolism Enzymes PRPS, HGPRT and PRPPAT." Fitoterapia, vol. 113, 2016, pp. 1-5.
Li HG, Hou PY, Zhang X, et al. Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT. Fitoterapia. 2016;113:1-5.
Li, H. G., Hou, P. Y., Zhang, X., He, Y., Zhang, J., Wang, S. Q., Anderson, S., Zhang, Y. W., & Wu, X. H. (2016). Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT. Fitoterapia, 113, 1-5. https://doi.org/10.1016/j.fitote.2016.06.015
Li HG, et al. Hypouricemic Effect of Allopurinol Are Improved By Pallidifloside D Based On the Uric Acid Metabolism Enzymes PRPS, HGPRT and PRPPAT. Fitoterapia. 2016;113:1-5. PubMed PMID: 27370097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT. AU - Li,Hong-Gang, AU - Hou,Pi-Yong, AU - Zhang,Xi, AU - He,Yi, AU - Zhang,Jun, AU - Wang,Shu-Qing, AU - Anderson,Samantha, AU - Zhang,Yan-Wen, AU - Wu,Xiao-Hui, Y1 - 2016/06/28/ PY - 2016/05/31/received PY - 2016/06/22/revised PY - 2016/06/25/accepted PY - 2016/7/3/entrez PY - 2016/7/3/pubmed PY - 2017/2/1/medline KW - Allopurinol KW - HGPRT KW - Hyperuricemia KW - PRPPAT KW - PRPS KW - Pallidifloside D SP - 1 EP - 5 JF - Fitoterapia JO - Fitoterapia VL - 113 N2 - Allopurinol is a commonly used medication to treat hyperuricemia and its complications. Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to enhanced hypouricemic effect of allopurinol based on uric acid metabolism enzyme XOD. In this study, we evaluated whether Pallidifloside D (5mg/kg) enhanced hypouricemic effect of allopurinol (5mg/kg) related to others uric acid metabolism enzymes such as PRPS, HGPRT and PRPPAT. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly up-regulated HGPRT mRNA expression and down-regulated the mRNA expression of PRPS and PRPPAT in PC12 cells (all P<0.01). These results strongly suggest that hypouricemic effect of allopurinol are improved by Pallidifloside D via numerous mechanisms and our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/27370097/Hypouricemic_effect_of_allopurinol_are_improved_by_Pallidifloside_D_based_on_the_uric_acid_metabolism_enzymes_PRPS_HGPRT_and_PRPPAT_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(16)30139-3 DB - PRIME DP - Unbound Medicine ER -