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Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness.

Abstract

OBJECTIVE

To evaluate the correlation between the level of adipocytokines expression in periprostatic adipose tissue and the prostate cancer aggressiveness.

PATIENTS AND METHOD

The periprostatic adipose tissues were collected from 30 patients who underwent radical retropubic prostatectomy. The subcutaneous adipose, periprostatic adipose tissues and prostate cancer tissue from the same patient were collected from 10 patients for match research. The expression level of IL-6, Leptin and Adiponectin was detected by immunohistochemistry and by Real-time quantitative PCR in periprostatic adipose tissues.

RESULT

There were differences in the positive rates of IL-6, Leptin and Adiponectin expression in the periprostate adipose between prostate cancer and control (P<0.001, P=0.032, 0.003). Nothing but the "IL-6 expression intensity" was seen in difference with the aggressiveness of prostate cancer (P=0.001), and was relevant with the prostate cancer aggressiveness (rs=0.668, P<0.001); The mRNA expression of IL-6 in periprostatic adipose tissues of prostate cancer was higher than that of control (P=0.049), and the mRNA expression of Adiponectin was lower (P<0.0001); IL-6 mRNA expression in periprostate adipose tissue and prostate cancer tissue were higher than that in subcutaneous adipose (P<0.001, P=0.001); IL-6 mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.663, p=0.036); Adiponectin mRNA expression in prostate cancer tissue was lower than that in periprostate adipose (P=0.006), and Adiponectin mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.707, p=0.022).

CONCLUSION

IL-6, Leptin and Adiponectin were expressed in the periprostatic adipose tissues, which constitute the microenvironment of prostate cancer aggressiveness. There might be intimate relationship between periprostate adipose and prostate cancer tissue.

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  • Authors+Show Affiliations

    ,

    Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.

    ,

    Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China. Electronic address: slj20151001@163.com.

    ,

    Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.

    ,

    Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

    Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.

    Source

    Cytokine 85: 2016 09 pg 148-56

    MeSH

    Adipokines
    Adipose Tissue
    Humans
    Interleukin-6
    Leptin
    Male
    Prostatic Neoplasms
    RNA, Messenger

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27371773

    Citation

    Zhang, Qiang, et al. "Influence of Adipocytokines in Periprostatic Adipose Tissue On Prostate Cancer Aggressiveness." Cytokine, vol. 85, 2016, pp. 148-56.
    Zhang Q, Sun LJ, Yang ZG, et al. Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness. Cytokine. 2016;85:148-56.
    Zhang, Q., Sun, L. J., Yang, Z. G., Zhang, G. M., & Huo, R. C. (2016). Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness. Cytokine, 85, pp. 148-56. doi:10.1016/j.cyto.2016.06.019.
    Zhang Q, et al. Influence of Adipocytokines in Periprostatic Adipose Tissue On Prostate Cancer Aggressiveness. Cytokine. 2016;85:148-56. PubMed PMID: 27371773.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness. AU - Zhang,Qiang, AU - Sun,Li-Jiang, AU - Yang,Zhi-Gang, AU - Zhang,Gui-Ming, AU - Huo,Ri-Cha, Y1 - 2016/06/29/ PY - 2016/01/06/received PY - 2016/06/14/revised PY - 2016/06/15/accepted PY - 2016/7/3/entrez PY - 2016/7/3/pubmed PY - 2017/12/30/medline KW - Adipocytokine KW - Adiponectin KW - IL-6 KW - Leptin KW - Periprostatic adipose tissue KW - Prostate cancer KW - Tumor aggressiveness SP - 148 EP - 56 JF - Cytokine JO - Cytokine VL - 85 N2 - OBJECTIVE: To evaluate the correlation between the level of adipocytokines expression in periprostatic adipose tissue and the prostate cancer aggressiveness. PATIENTS AND METHOD: The periprostatic adipose tissues were collected from 30 patients who underwent radical retropubic prostatectomy. The subcutaneous adipose, periprostatic adipose tissues and prostate cancer tissue from the same patient were collected from 10 patients for match research. The expression level of IL-6, Leptin and Adiponectin was detected by immunohistochemistry and by Real-time quantitative PCR in periprostatic adipose tissues. RESULT: There were differences in the positive rates of IL-6, Leptin and Adiponectin expression in the periprostate adipose between prostate cancer and control (P<0.001, P=0.032, 0.003). Nothing but the "IL-6 expression intensity" was seen in difference with the aggressiveness of prostate cancer (P=0.001), and was relevant with the prostate cancer aggressiveness (rs=0.668, P<0.001); The mRNA expression of IL-6 in periprostatic adipose tissues of prostate cancer was higher than that of control (P=0.049), and the mRNA expression of Adiponectin was lower (P<0.0001); IL-6 mRNA expression in periprostate adipose tissue and prostate cancer tissue were higher than that in subcutaneous adipose (P<0.001, P=0.001); IL-6 mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.663, p=0.036); Adiponectin mRNA expression in prostate cancer tissue was lower than that in periprostate adipose (P=0.006), and Adiponectin mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.707, p=0.022). CONCLUSION: IL-6, Leptin and Adiponectin were expressed in the periprostatic adipose tissues, which constitute the microenvironment of prostate cancer aggressiveness. There might be intimate relationship between periprostate adipose and prostate cancer tissue. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/27371773/Influence_of_adipocytokines_in_periprostatic_adipose_tissue_on_prostate_cancer_aggressiveness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(16)30147-8 DB - PRIME DP - Unbound Medicine ER -