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Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats.
Biomed Pharmacother. 2016 Oct; 83:167-176.BP

Abstract

High-fat diet (HFD) promotes the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. The objective of this study was to evaluate the protective effect of Caralluma fimbriata on high-fat diet-induced oxidative stress in the testis of rat. Male Wistar rats were randomly divided into five groups: Control (C), Control treated with CFE (C+ CFE), High fat diet fed (HFD), High fat diet fed treated with CFE (HFD+CFE) and High fat diet fed treated with Metformin (HFD+Met). CFE was orally administered (200mg/kg body weight) for 90days to groups-C+CFE and HFD+CFE rats. The effects of HF-diet on the reproductive organs were determined by measuring relative and absolute testes and epididymal fat pads weights. Regarding testes antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation, polyol pathway enzymes and lower GSH levels and lower activities of antioxidants, while CFE treatment prevented all these observed abnormalities. The present study clearly indicates that CFE offers a significant protection against HF-diet induced testicular oxidative stress in rats.

Authors+Show Affiliations

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, India.Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, India.Department of Zoology, Sri Krishnadevaraya University, Anantapur, 515003, India.Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, India.Department of Biochemistry, Sri Venkateswara University, Tirupati, 517502, India.Green Chem Herbal Extract and Formulations, Bangalore, 560071, India.Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, India. Electronic address: desireddysaralakumari8@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27372404

Citation

Gujjala, Sudhakara, et al. "Protective Effect of Caralluma Fimbriata Against High-fat Diet Induced Testicular Oxidative Stress in Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 83, 2016, pp. 167-176.
Gujjala S, Putakala M, Gangarapu V, et al. Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats. Biomed Pharmacother. 2016;83:167-176.
Gujjala, S., Putakala, M., Gangarapu, V., Nukala, S., Bellamkonda, R., Ramaswamy, R., & Desireddy, S. (2016). Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 83, 167-176. https://doi.org/10.1016/j.biopha.2016.06.031
Gujjala S, et al. Protective Effect of Caralluma Fimbriata Against High-fat Diet Induced Testicular Oxidative Stress in Rats. Biomed Pharmacother. 2016;83:167-176. PubMed PMID: 27372404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats. AU - Gujjala,Sudhakara, AU - Putakala,Mallaiah, AU - Gangarapu,Venkatanarayana, AU - Nukala,Srinivasulu, AU - Bellamkonda,Ramesh, AU - Ramaswamy,Rajendran, AU - Desireddy,Saralakumari, Y1 - 2016/06/28/ PY - 2016/03/22/received PY - 2016/06/10/revised PY - 2016/06/16/accepted PY - 2016/10/25/pubmed PY - 2017/1/31/medline PY - 2016/7/4/entrez KW - Antioxidant enzymes KW - Caralluma fimbriata KW - High-fat diet KW - Oxidative stress SP - 167 EP - 176 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 83 N2 - High-fat diet (HFD) promotes the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. The objective of this study was to evaluate the protective effect of Caralluma fimbriata on high-fat diet-induced oxidative stress in the testis of rat. Male Wistar rats were randomly divided into five groups: Control (C), Control treated with CFE (C+ CFE), High fat diet fed (HFD), High fat diet fed treated with CFE (HFD+CFE) and High fat diet fed treated with Metformin (HFD+Met). CFE was orally administered (200mg/kg body weight) for 90days to groups-C+CFE and HFD+CFE rats. The effects of HF-diet on the reproductive organs were determined by measuring relative and absolute testes and epididymal fat pads weights. Regarding testes antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation, polyol pathway enzymes and lower GSH levels and lower activities of antioxidants, while CFE treatment prevented all these observed abnormalities. The present study clearly indicates that CFE offers a significant protection against HF-diet induced testicular oxidative stress in rats. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/27372404/Protective_effect_of_Caralluma_fimbriata_against_high_fat_diet_induced_testicular_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(16)30354-7 DB - PRIME DP - Unbound Medicine ER -