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Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes.
Can J Diabetes. 2016 Oct; 40(5):442-448.CJ

Abstract

OBJECTIVES

We evaluated the effects of S-allylcysteine (SAC) on biomarkers of the polyol pathway in streptozotocin-nicotinamide (STZ-NA)-induced diabetes in rats.

METHODS

Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (55 mg kg-1 bw-1) and NA (110 mg kg-1 bw-1). SAC (150 mg kg-1 bw-1) was orally administered to the rats with diabetes for 45 days to assess its effects on blood glucose, insulin, insulin resistance, glycated hemoglobin, aldose reductase (AR), sorbitol dehydrogenase (SDH), sorbitol, fructose, thiobarbituric acid-reactive substances (TBARS), hydroperoxide, hemoglobin and glutathione (GSH).

RESULTS

On SAC administration in the rats with diabetes, the levels of blood glucose, insulin resistance, glycated hemoglobin, AR, SDH, sorbitol, fructose, TBARS and hydroperoxide increased significantly (p<0.05), whereas those of insulin, hemoglobin and GSH decreased. SAC showed therapeutic effects similar to those of gliclazide in decreasing blood glucose, AR, SDH, sorbitol, fructose, glycosylated hemoglobin, TBARS and hydroperoxides levels and significant increases in insulin, hemoglobin and GSH activity in rats with diabetes. Moreover, histopathologic studies also revealed the protective effect of SAC on pancreatic beta cells.

CONCLUSIONS

The results indicate that SAC prevents complications of diabetes by reducing the influx of glucose in the polyol pathway, thereby elevating the GSH level and reducing the activities of AR and SDH. Therefore, SAC may have imperative implications for the deterrence and early treatment of type 2 diabetes.

Authors+Show Affiliations

Animal Physiology and Biochemistry Laboratory, Department of Biochemistry, Sri Venkateswara University, Tirupati, India.Department of Biochemistry, Centre for Biological Science, K. S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India.National Center for Laboratory Animal Sciences, National Institute of Nutrition (ICMR), New Delhi, India.National Center for Laboratory Animal Sciences, National Institute of Nutrition (ICMR), New Delhi, India.Department of Zoology, Osmania University, Hyderabad, India.Animal Physiology and Biochemistry Laboratory, Department of Biochemistry, Sri Venkateswara University, Tirupati, India.Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India.Department of Biotechnology, Centre for Biological Science, K. S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India.Department of Biochemistry, Centre for Biological Science, K. S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India.Department of Biochemistry, Centre for Biological Science, K. S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India. Electronic address: saravana_bioc@rediffmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27373435

Citation

Naidu, Parim Brahma, et al. "Effects of S-Allylcysteine On Biomarkers of the Polyol Pathway in Rats With Type 2 Diabetes." Canadian Journal of Diabetes, vol. 40, no. 5, 2016, pp. 442-448.
Naidu PB, Sathibabu Uddandrao VV, Naik RR, et al. Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. Can J Diabetes. 2016;40(5):442-448.
Naidu, P. B., Sathibabu Uddandrao, V. V., Naik, R. R., Pothani, S., Munipally, P. K., Meriga, B., Begum, M. S., Varatharaju, C., Pandiyan, R., & Saravanan, G. (2016). Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. Canadian Journal of Diabetes, 40(5), 442-448. https://doi.org/10.1016/j.jcjd.2016.03.006
Naidu PB, et al. Effects of S-Allylcysteine On Biomarkers of the Polyol Pathway in Rats With Type 2 Diabetes. Can J Diabetes. 2016;40(5):442-448. PubMed PMID: 27373435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. AU - Naidu,Parim Brahma, AU - Sathibabu Uddandrao,V V, AU - Naik,Ramavat Ravindar, AU - Pothani,Suresh, AU - Munipally,Praveen Kumar, AU - Meriga,Balaji, AU - Begum,Mustapha Sabana, AU - Varatharaju,Chandrasekar, AU - Pandiyan,Rajesh, AU - Saravanan,Ganapathy, Y1 - 2016/07/01/ PY - 2015/07/21/received PY - 2016/03/21/revised PY - 2016/03/23/accepted PY - 2016/7/5/pubmed PY - 2017/2/7/medline PY - 2016/7/5/entrez KW - Diabète KW - S-allyl-cystéine KW - S-allylcysteine KW - diabetes KW - lipid peroxidation KW - peroxydation des lipides KW - polyol pathway KW - streptozotocin KW - streptozotocine KW - voie des polyols SP - 442 EP - 448 JF - Canadian journal of diabetes JO - Can J Diabetes VL - 40 IS - 5 N2 - OBJECTIVES: We evaluated the effects of S-allylcysteine (SAC) on biomarkers of the polyol pathway in streptozotocin-nicotinamide (STZ-NA)-induced diabetes in rats. METHODS: Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (55 mg kg-1 bw-1) and NA (110 mg kg-1 bw-1). SAC (150 mg kg-1 bw-1) was orally administered to the rats with diabetes for 45 days to assess its effects on blood glucose, insulin, insulin resistance, glycated hemoglobin, aldose reductase (AR), sorbitol dehydrogenase (SDH), sorbitol, fructose, thiobarbituric acid-reactive substances (TBARS), hydroperoxide, hemoglobin and glutathione (GSH). RESULTS: On SAC administration in the rats with diabetes, the levels of blood glucose, insulin resistance, glycated hemoglobin, AR, SDH, sorbitol, fructose, TBARS and hydroperoxide increased significantly (p<0.05), whereas those of insulin, hemoglobin and GSH decreased. SAC showed therapeutic effects similar to those of gliclazide in decreasing blood glucose, AR, SDH, sorbitol, fructose, glycosylated hemoglobin, TBARS and hydroperoxides levels and significant increases in insulin, hemoglobin and GSH activity in rats with diabetes. Moreover, histopathologic studies also revealed the protective effect of SAC on pancreatic beta cells. CONCLUSIONS: The results indicate that SAC prevents complications of diabetes by reducing the influx of glucose in the polyol pathway, thereby elevating the GSH level and reducing the activities of AR and SDH. Therefore, SAC may have imperative implications for the deterrence and early treatment of type 2 diabetes. SN - 2352-3840 UR - https://www.unboundmedicine.com/medline/citation/27373435/Effects_of_S_Allylcysteine_on_Biomarkers_of_the_Polyol_Pathway_in_Rats_with_Type_2_Diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1499-2671(16)30057-0 DB - PRIME DP - Unbound Medicine ER -