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Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB4 Production by Peritoneal Exudate Cells of Rats.
Biosci Biotechnol Biochem 2001; 65(2):315-21BB

Abstract

The interaction of dietary fats and proteins on lipid parameters of rats was studied using safflower oil (linoleic acid-rich), borage oil (γ-linolenic acid-rich) or perilla oil (α-linolenic acid-rich) in combination with casein or soybean protein. The experiment was focused on the fatty acid composition of immune cells and the leukotriene B4 production by peritoneal exudate cells. Serum total cholesterol, triglyceride, and phospholipid levels were low in perilla oil-fed or soybean protein-fed rats. Fatty acid compositions of serum and liver phospholipids reflected those of dietary fats. However, feeding borage oil resulted in a marked increase in the proportion of dihomo-γ-linolenic acid in phospholipids of peritoneal exudate cells, spleen lymphocytes, and mesenteric lymph node lymphocytes in relation to those of liver and serum. It is suggested that activities of metabolic n-6 polyunsaturated fatty acids are different between immune and other tissues. In addition, the magnitude of the reduction of the proportion of linoleic acid of perilla oil in immune cells was considerably more moderate than serum and liver, indicating a different degree of interference of α-linolenic acid with linoleic acid metabolism. Leukotriene B4 release from peritoneal exudate cells was in the order of safflower oil>borage oil>perilla oil groups as reflecting the proportion of arachidonic acid, and tended to be lower in soybean protein-fed groups. These suggest an anti-inflammatory property of γ-linolenic acid as well as α-linolenic acid tended to be strengthened when they were combined with soybean protein than with casein.

Authors+Show Affiliations

a Study of Food and Health Environment, Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto.b Department of Bioscience and Biotechnology, Division of Bioenvironmental Sciences, Graduate School of Kyushu University.b Department of Bioscience and Biotechnology, Division of Bioenvironmental Sciences, Graduate School of Kyushu University.a Study of Food and Health Environment, Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto.b Department of Bioscience and Biotechnology, Division of Bioenvironmental Sciences, Graduate School of Kyushu University.b Department of Bioscience and Biotechnology, Division of Bioenvironmental Sciences, Graduate School of Kyushu University.b Department of Bioscience and Biotechnology, Division of Bioenvironmental Sciences, Graduate School of Kyushu University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27374271

Citation

Kaku, S, et al. "Interactions of Dietary Fats and Proteins On Fatty Acid Composition of Immune Cells and LTB4 Production By Peritoneal Exudate Cells of Rats." Bioscience, Biotechnology, and Biochemistry, vol. 65, no. 2, 2001, pp. 315-21.
Kaku S, Yunoki S, Ohkura K, et al. Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB4 Production by Peritoneal Exudate Cells of Rats. Biosci Biotechnol Biochem. 2001;65(2):315-21.
Kaku, S., Yunoki, S., Ohkura, K., Sugano, M., Nonaka, M., Tachibana, H., & Yamada, K. (2001). Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB4 Production by Peritoneal Exudate Cells of Rats. Bioscience, Biotechnology, and Biochemistry, 65(2), pp. 315-21. doi:10.1271/bbb.65.315.
Kaku S, et al. Interactions of Dietary Fats and Proteins On Fatty Acid Composition of Immune Cells and LTB4 Production By Peritoneal Exudate Cells of Rats. Biosci Biotechnol Biochem. 2001;65(2):315-21. PubMed PMID: 27374271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB4 Production by Peritoneal Exudate Cells of Rats. AU - Kaku,S, AU - Yunoki,S, AU - Ohkura,K, AU - Sugano,M, AU - Nonaka,M, AU - Tachibana,H, AU - Yamada,K, PY - 2016/7/5/entrez PY - 2001/1/1/pubmed PY - 2001/1/1/medline KW - lipid metabolism KW - lymphocyte KW - soybean protein KW - α-linolenic acid KW - γ-linolenic acid SP - 315 EP - 21 JF - Bioscience, biotechnology, and biochemistry JO - Biosci. Biotechnol. Biochem. VL - 65 IS - 2 N2 - The interaction of dietary fats and proteins on lipid parameters of rats was studied using safflower oil (linoleic acid-rich), borage oil (γ-linolenic acid-rich) or perilla oil (α-linolenic acid-rich) in combination with casein or soybean protein. The experiment was focused on the fatty acid composition of immune cells and the leukotriene B4 production by peritoneal exudate cells. Serum total cholesterol, triglyceride, and phospholipid levels were low in perilla oil-fed or soybean protein-fed rats. Fatty acid compositions of serum and liver phospholipids reflected those of dietary fats. However, feeding borage oil resulted in a marked increase in the proportion of dihomo-γ-linolenic acid in phospholipids of peritoneal exudate cells, spleen lymphocytes, and mesenteric lymph node lymphocytes in relation to those of liver and serum. It is suggested that activities of metabolic n-6 polyunsaturated fatty acids are different between immune and other tissues. In addition, the magnitude of the reduction of the proportion of linoleic acid of perilla oil in immune cells was considerably more moderate than serum and liver, indicating a different degree of interference of α-linolenic acid with linoleic acid metabolism. Leukotriene B4 release from peritoneal exudate cells was in the order of safflower oil>borage oil>perilla oil groups as reflecting the proportion of arachidonic acid, and tended to be lower in soybean protein-fed groups. These suggest an anti-inflammatory property of γ-linolenic acid as well as α-linolenic acid tended to be strengthened when they were combined with soybean protein than with casein. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/27374271/Interactions_of_Dietary_Fats_and_Proteins_on_Fatty_Acid_Composition_of_Immune_Cells_and_LTB4_Production_by_Peritoneal_Exudate_Cells_of_Rats_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/65.315?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -