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Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials.
Neuropsychiatr Dis Treat. 2016; 12:1435-44.ND

Abstract

BACKGROUND

Parkinson's disease (PD) is a common neurodegenerative disorder that affects many people every year. Deep brain stimulation (DBS) is an effective nonpharmacological method to treat PD motor symptoms. This meta-analysis was conducted to evaluate the efficacy of subthalamic nucleus (STN)-DBS versus globus pallidus internus (GPi)-DBS in treating advanced PD.

METHODS

Controlled clinical trials that compared STN-DBS to GPi-DBS for short-term treatment of PD in adults were researched up to November 2015. The primary outcomes were the Unified Parkinson's Disease Rating Scale Section (UPDRS) III score and the levodopa-equivalent dosage (LED) after DBS. The secondary outcomes were the UPDRS II score and the Beck Depression Inventory (BDI) score.

RESULTS

Totally, 13 studies containing 1,148 PD patients were included in this meta-analysis to compare STN-DBS versus GPi-DBS. During the off-medication state, the pooled weighted mean difference (WMD) of UPDRS III and II scores were -2.18 (95% CI =-5.11 to 0.74) and -1.96 (95% CI =-3.84 to -0.08), respectively. During the on-medication state, the pooled WMD of UPDRS III and II scores were 0.15 (95% CI =-1.14 to 1.44) and 1.01 (95% CI =0.12 to 1.89), respectively. After DBS, the pooled WMD of LED and BDI were -254.48 (95% CI =-341.66) and 2.29 (95% CI =0.83 to 3.75), respectively.

CONCLUSION

These results indicate that during the off-medication state, the STN-DBS might be superior to GPi-DBS in improving the motor function and activities of daily living for PD patients; but during the on-medication state, the opposite result is observed. Meanwhile, the STN-DBS is superior at reducing the LED, whereas the GPi-DBS shows a significantly greater reduction in BDI score after DBS.

Authors+Show Affiliations

Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, People's Republic of China.Department of Neurology, Binzhou Medical University Hospital, Binzhou, Shandong, People's Republic of China.Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, People's Republic of China.Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, People's Republic of China.Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27382286

Citation

Xu, Fan, et al. "Deep Brain Stimulation of Pallidal Versus Subthalamic for Patients With Parkinson's Disease: a Meta-analysis of Controlled Clinical Trials." Neuropsychiatric Disease and Treatment, vol. 12, 2016, pp. 1435-44.
Xu F, Ma W, Huang Y, et al. Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials. Neuropsychiatr Dis Treat. 2016;12:1435-44.
Xu, F., Ma, W., Huang, Y., Qiu, Z., & Sun, L. (2016). Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials. Neuropsychiatric Disease and Treatment, 12, 1435-44. https://doi.org/10.2147/NDT.S105513
Xu F, et al. Deep Brain Stimulation of Pallidal Versus Subthalamic for Patients With Parkinson's Disease: a Meta-analysis of Controlled Clinical Trials. Neuropsychiatr Dis Treat. 2016;12:1435-44. PubMed PMID: 27382286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials. AU - Xu,Fan, AU - Ma,Wenbin, AU - Huang,Yongmin, AU - Qiu,Zhihai, AU - Sun,Lei, Y1 - 2016/06/22/ PY - 2016/7/7/entrez PY - 2016/7/7/pubmed PY - 2016/7/7/medline KW - Parkinson disease KW - deep brain stimulation KW - globus pallidus internus KW - subthalamic nucleus SP - 1435 EP - 44 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 12 N2 - BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder that affects many people every year. Deep brain stimulation (DBS) is an effective nonpharmacological method to treat PD motor symptoms. This meta-analysis was conducted to evaluate the efficacy of subthalamic nucleus (STN)-DBS versus globus pallidus internus (GPi)-DBS in treating advanced PD. METHODS: Controlled clinical trials that compared STN-DBS to GPi-DBS for short-term treatment of PD in adults were researched up to November 2015. The primary outcomes were the Unified Parkinson's Disease Rating Scale Section (UPDRS) III score and the levodopa-equivalent dosage (LED) after DBS. The secondary outcomes were the UPDRS II score and the Beck Depression Inventory (BDI) score. RESULTS: Totally, 13 studies containing 1,148 PD patients were included in this meta-analysis to compare STN-DBS versus GPi-DBS. During the off-medication state, the pooled weighted mean difference (WMD) of UPDRS III and II scores were -2.18 (95% CI =-5.11 to 0.74) and -1.96 (95% CI =-3.84 to -0.08), respectively. During the on-medication state, the pooled WMD of UPDRS III and II scores were 0.15 (95% CI =-1.14 to 1.44) and 1.01 (95% CI =0.12 to 1.89), respectively. After DBS, the pooled WMD of LED and BDI were -254.48 (95% CI =-341.66) and 2.29 (95% CI =0.83 to 3.75), respectively. CONCLUSION: These results indicate that during the off-medication state, the STN-DBS might be superior to GPi-DBS in improving the motor function and activities of daily living for PD patients; but during the on-medication state, the opposite result is observed. Meanwhile, the STN-DBS is superior at reducing the LED, whereas the GPi-DBS shows a significantly greater reduction in BDI score after DBS. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/27382286/Deep_brain_stimulation_of_pallidal_versus_subthalamic_for_patients_with_Parkinson's_disease:_a_meta_analysis_of_controlled_clinical_trials_ L2 - https://dx.doi.org/10.2147/NDT.S105513 DB - PRIME DP - Unbound Medicine ER -
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