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Phytochemical screening, antiglycation and antioxidant activities of whole plant of Boerhavia repens L. from Cholistan, Pakistan.
Pak J Pharm Sci. 2016 May; 29(3 Suppl):1063-70.PJ

Abstract

Present study was aimed to explore a traditionally used indigenous medicinal plant Boerhavia repens (Nyctaginaceae family) of the Cholistan desert, Pakistan. Crude aqueous and methanolic extracts of the whole plant were investigated in vitro for preliminary phytochemical screening, antioxidant and antiglycation activities. Antioxidant activities were determined by total phenolic contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and inhibition of lipid peroxidation. For antiglycation activities browning production was noted and thiobarbituric acid (TBA) technique was used to determine glycation level. Boerhavia repens expressed considerable amounts of phytochemicals. Extract yield was found to be 4.59%-7.85% g/100g of dry matter with total phenolics ranging from 47.9- 190.77mg/GAE per g for aqueous and methanol extract respectively. Strong inhibitory effect was exhibited by methanolic extract in linoleic acid per oxidation system (86.11%, EC50=0.99mg/mL) and DPPH assay (88.65%, EC50=212.33μg/ml). In term of browning maximum inhibition (81.50%) was exhibited by methanolic extract at 37°C at third week of incubation. Both extracts expressed significant (P>0.05) and comparable inhibition of glycation level. In conclusion, Boerhavia repens showed promising antioxidant and antiglycation activities validating its therapeutic potential.

Authors+Show Affiliations

Department of Biochemistry and University of Agriculture, Faisalabad, Pakistan.Department of Biochemistry and University of Agriculture, Faisalabad, Pakistan.Department of Biochemistry and University of Agriculture, Faisalabad, Pakistan.Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27383484

Citation

Nazneen, Fariha, et al. "Phytochemical Screening, Antiglycation and Antioxidant Activities of Whole Plant of Boerhavia Repens L. From Cholistan, Pakistan." Pakistan Journal of Pharmaceutical Sciences, vol. 29, no. 3 Suppl, 2016, pp. 1063-70.
Nazneen F, Sheikh MA, Jameel A, et al. Phytochemical screening, antiglycation and antioxidant activities of whole plant of Boerhavia repens L. from Cholistan, Pakistan. Pak J Pharm Sci. 2016;29(3 Suppl):1063-70.
Nazneen, F., Sheikh, M. A., Jameel, A., & Rahman, Z. (2016). Phytochemical screening, antiglycation and antioxidant activities of whole plant of Boerhavia repens L. from Cholistan, Pakistan. Pakistan Journal of Pharmaceutical Sciences, 29(3 Suppl), 1063-70.
Nazneen F, et al. Phytochemical Screening, Antiglycation and Antioxidant Activities of Whole Plant of Boerhavia Repens L. From Cholistan, Pakistan. Pak J Pharm Sci. 2016;29(3 Suppl):1063-70. PubMed PMID: 27383484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical screening, antiglycation and antioxidant activities of whole plant of Boerhavia repens L. from Cholistan, Pakistan. AU - Nazneen,Fariha, AU - Sheikh,Munir A, AU - Jameel,Amir, AU - Rahman,Ziaur, PY - 2016/7/8/entrez PY - 2016/7/8/pubmed PY - 2017/1/7/medline SP - 1063 EP - 70 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 29 IS - 3 Suppl N2 - Present study was aimed to explore a traditionally used indigenous medicinal plant Boerhavia repens (Nyctaginaceae family) of the Cholistan desert, Pakistan. Crude aqueous and methanolic extracts of the whole plant were investigated in vitro for preliminary phytochemical screening, antioxidant and antiglycation activities. Antioxidant activities were determined by total phenolic contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and inhibition of lipid peroxidation. For antiglycation activities browning production was noted and thiobarbituric acid (TBA) technique was used to determine glycation level. Boerhavia repens expressed considerable amounts of phytochemicals. Extract yield was found to be 4.59%-7.85% g/100g of dry matter with total phenolics ranging from 47.9- 190.77mg/GAE per g for aqueous and methanol extract respectively. Strong inhibitory effect was exhibited by methanolic extract in linoleic acid per oxidation system (86.11%, EC50=0.99mg/mL) and DPPH assay (88.65%, EC50=212.33μg/ml). In term of browning maximum inhibition (81.50%) was exhibited by methanolic extract at 37°C at third week of incubation. Both extracts expressed significant (P>0.05) and comparable inhibition of glycation level. In conclusion, Boerhavia repens showed promising antioxidant and antiglycation activities validating its therapeutic potential. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/27383484/Phytochemical_screening_antiglycation_and_antioxidant_activities_of_whole_plant_of_Boerhavia_repens_L__from_Cholistan_Pakistan_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -