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Aripiprazole for the treatment of irritability and aggression in children and adolescents affected by autism spectrum disorders.
Expert Rev Neurother. 2016 08; 16(8):867-74.ER

Abstract

INTRODUCTION

Aripiprazole is an atypical antipsychotic approved for the treatment of irritability and aggression in children and adolescents aged 6-17 years with autism spectrum disorder.

AREAS COVERED

This review will discuss the drug profile as well as available studies of aripiprazole in individuals with autism spectrum disorder as documented in prospective randomized controlled trials. Expert commentary: The heterogeneity of autism spectrum disorder has implications for assessing the effectiveness and safety of aripiprazole as it may not produce the same results in two individuals with the same diagnosis but different etiologies. Subgrouping of patients according to their overall presentation of symptoms may therefore be warranted. In addition, consideration should be given to the potential causes of irritability and aggression, such as coexisting medical conditions and environmental factors including inappropriate intervention of parents and teachers. In these cases, the identification of the underlying cause is important because the appropriate management.

Authors+Show Affiliations

a Child and Adolescent Neurology and Psychiatry, Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.b Unit of Pediatrics and Pediatric Emergency , University Hospital "Policlinico-Vittorio Emanuele," , Catania , Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27388494

Citation

Rizzo, Renata, and Piero Pavone. "Aripiprazole for the Treatment of Irritability and Aggression in Children and Adolescents Affected By Autism Spectrum Disorders." Expert Review of Neurotherapeutics, vol. 16, no. 8, 2016, pp. 867-74.
Rizzo R, Pavone P. Aripiprazole for the treatment of irritability and aggression in children and adolescents affected by autism spectrum disorders. Expert Rev Neurother. 2016;16(8):867-74.
Rizzo, R., & Pavone, P. (2016). Aripiprazole for the treatment of irritability and aggression in children and adolescents affected by autism spectrum disorders. Expert Review of Neurotherapeutics, 16(8), 867-74. https://doi.org/10.1080/14737175.2016.1211007
Rizzo R, Pavone P. Aripiprazole for the Treatment of Irritability and Aggression in Children and Adolescents Affected By Autism Spectrum Disorders. Expert Rev Neurother. 2016;16(8):867-74. PubMed PMID: 27388494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aripiprazole for the treatment of irritability and aggression in children and adolescents affected by autism spectrum disorders. AU - Rizzo,Renata, AU - Pavone,Piero, Y1 - 2016/07/19/ PY - 2016/7/9/entrez PY - 2016/7/9/pubmed PY - 2017/6/9/medline KW - Autism spectrum disorder KW - aggression KW - aripiprazole KW - irritability KW - treatment SP - 867 EP - 74 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 16 IS - 8 N2 - INTRODUCTION: Aripiprazole is an atypical antipsychotic approved for the treatment of irritability and aggression in children and adolescents aged 6-17 years with autism spectrum disorder. AREAS COVERED: This review will discuss the drug profile as well as available studies of aripiprazole in individuals with autism spectrum disorder as documented in prospective randomized controlled trials. Expert commentary: The heterogeneity of autism spectrum disorder has implications for assessing the effectiveness and safety of aripiprazole as it may not produce the same results in two individuals with the same diagnosis but different etiologies. Subgrouping of patients according to their overall presentation of symptoms may therefore be warranted. In addition, consideration should be given to the potential causes of irritability and aggression, such as coexisting medical conditions and environmental factors including inappropriate intervention of parents and teachers. In these cases, the identification of the underlying cause is important because the appropriate management. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/27388494/Aripiprazole_for_the_treatment_of_irritability_and_aggression_in_children_and_adolescents_affected_by_autism_spectrum_disorders_ L2 - http://www.tandfonline.com/doi/full/10.1080/14737175.2016.1211007 DB - PRIME DP - Unbound Medicine ER -