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Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition.
Oncotarget 2017; 8(9):14479-14486O

Abstract

Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and cancer progression. However, the expression and function of SPRY4-IT1 in the progression of CRC remains largely unknown. Here, we reported that SPRY4-IT1 was upregulated in CRC. Increased SPRY4-IT1 expression in CRC was associated with larger tumor size and higher clinical stage. In vitro experiments revealed that SPRY4-IT1 knockdown significantly inhibited CRC cell proliferation by causing G1 arrest and promoting apoptosis, whereas SPRY4-IT1 overexpression promoted cell proliferation. Further functional assays indicated that SPRY4-IT1 overexpression significantly promoted cell migration and invasion by regulate the epithelial-mesenchymal transition (EMT). Taken together, our study demonstrates that SPRY4-IT1 could act as a functional oncogene in CRC, as well as a potential therapeutic target to inhibit CRC metastasis.

Authors+Show Affiliations

Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Experimental Medical Research Center, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Huizhou First People's Hospital, Huizhou, P.R. China.Department of General Surgery, Huizhou First People's Hospital, Huizhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27391336

Citation

Shen, Fei, et al. "Long Non-coding RNA SPRY4-IT1 Pormotes Colorectal Cancer Metastasis By Regulate Epithelial-mesenchymal Transition." Oncotarget, vol. 8, no. 9, 2017, pp. 14479-14486.
Shen F, Cai WS, Feng Z, et al. Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition. Oncotarget. 2017;8(9):14479-14486.
Shen, F., Cai, W. S., Feng, Z., Chen, J. W., Feng, J. H., Liu, Q. C., ... Xu, B. (2017). Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition. Oncotarget, 8(9), pp. 14479-14486. doi:10.18632/oncotarget.10407.
Shen F, et al. Long Non-coding RNA SPRY4-IT1 Pormotes Colorectal Cancer Metastasis By Regulate Epithelial-mesenchymal Transition. Oncotarget. 2017 Feb 28;8(9):14479-14486. PubMed PMID: 27391336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition. AU - Shen,Fei, AU - Cai,Wen-Song, AU - Feng,Zhe, AU - Chen,Ji-Wei, AU - Feng,Jian-Hua, AU - Liu,Qi-Cai, AU - Fang,Yong-Ping, AU - Li,Kun-Ping, AU - Xiao,Huan-Qing, AU - Cao,Jie, AU - Xu,Bo, PY - 2016/03/28/received PY - 2016/06/17/accepted PY - 2016/7/9/pubmed PY - 2017/10/11/medline PY - 2016/7/9/entrez KW - CRC KW - EMT KW - LncRNA KW - SPRY4-IT1 KW - metastasis SP - 14479 EP - 14486 JF - Oncotarget JO - Oncotarget VL - 8 IS - 9 N2 - Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and cancer progression. However, the expression and function of SPRY4-IT1 in the progression of CRC remains largely unknown. Here, we reported that SPRY4-IT1 was upregulated in CRC. Increased SPRY4-IT1 expression in CRC was associated with larger tumor size and higher clinical stage. In vitro experiments revealed that SPRY4-IT1 knockdown significantly inhibited CRC cell proliferation by causing G1 arrest and promoting apoptosis, whereas SPRY4-IT1 overexpression promoted cell proliferation. Further functional assays indicated that SPRY4-IT1 overexpression significantly promoted cell migration and invasion by regulate the epithelial-mesenchymal transition (EMT). Taken together, our study demonstrates that SPRY4-IT1 could act as a functional oncogene in CRC, as well as a potential therapeutic target to inhibit CRC metastasis. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/27391336/Long_non_coding_RNA_SPRY4_IT1_pormotes_colorectal_cancer_metastasis_by_regulate_epithelial_mesenchymal_transition_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=10407 DB - PRIME DP - Unbound Medicine ER -