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Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice.
PLoS One. 2016; 11(7):e0159059.Plos

Abstract

To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composition of the bone marrow, blood, and spleen by inducing myelopoiesis and enhancing the frequency of regulatory T cells in the CD4 population. Expansion of the myeloid cell compartment was due to cells identified as immature inflammatory myeloid cells having the phenotype of myeloid-derived suppressor cells of either the granulocytic or the monocytic type. Catecholaminergic as well as TNF signaling were implicated in these CSC-induced cellular shifts. Although the frequency of regulatory cells was enhanced following CSC, the high capacity for inflammatory cytokine secretion of total splenocytes indicated an inflammatory immune status in CSC mice. Furthermore, CSC enhanced the suppressive activity of bone marrow-derived myeloid-derived suppressor cells towards proliferating T cells. In line with the occurrence of suppressor cell types such as regulatory T cells and myeloid-derived suppressor cells, transplanted syngeneic fibrosarcoma cells grew better in CSC mice than in controls, a process accompanied by pronounced angiogenesis and clustering of immature myeloid cells in the tumor tissue. In addition, tumor implantation after CSC reinforced the CSC-induced increase in myeloid-derived suppressor cells and regulatory T cell frequencies while the CSC-induced cellular changes eased off in mice without tumor. Together, our data suggest a role for suppressor cells such as regulatory T cells and myeloid-derived suppressor cells in the enhanced tumor growth after chronic psychosocial stress.

Authors+Show Affiliations

Institute of Immunology, University of Regensburg, Regensburg, Germany.Institute of Zoology, Laboratory of Molecular and Cellular Neurobiology, University of Regensburg, Regensburg, Germany.Institute of Zoology, Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.Institute of Immunology, University of Regensburg, Regensburg, Germany.Institute of Immunology, University of Regensburg, Regensburg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27391954

Citation

Schmidt, Dominic, et al. "Induction of Suppressor Cells and Increased Tumor Growth Following Chronic Psychosocial Stress in Male Mice." PloS One, vol. 11, no. 7, 2016, pp. e0159059.
Schmidt D, Peterlik D, Reber SO, et al. Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. PLoS One. 2016;11(7):e0159059.
Schmidt, D., Peterlik, D., Reber, S. O., Lechner, A., & Männel, D. N. (2016). Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. PloS One, 11(7), e0159059. https://doi.org/10.1371/journal.pone.0159059
Schmidt D, et al. Induction of Suppressor Cells and Increased Tumor Growth Following Chronic Psychosocial Stress in Male Mice. PLoS One. 2016;11(7):e0159059. PubMed PMID: 27391954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. AU - Schmidt,Dominic, AU - Peterlik,Daniel, AU - Reber,Stefan O, AU - Lechner,Anja, AU - Männel,Daniela N, Y1 - 2016/07/08/ PY - 2016/02/22/received PY - 2016/06/27/accepted PY - 2016/7/9/entrez PY - 2016/7/9/pubmed PY - 2017/8/19/medline SP - e0159059 EP - e0159059 JF - PloS one JO - PLoS One VL - 11 IS - 7 N2 - To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composition of the bone marrow, blood, and spleen by inducing myelopoiesis and enhancing the frequency of regulatory T cells in the CD4 population. Expansion of the myeloid cell compartment was due to cells identified as immature inflammatory myeloid cells having the phenotype of myeloid-derived suppressor cells of either the granulocytic or the monocytic type. Catecholaminergic as well as TNF signaling were implicated in these CSC-induced cellular shifts. Although the frequency of regulatory cells was enhanced following CSC, the high capacity for inflammatory cytokine secretion of total splenocytes indicated an inflammatory immune status in CSC mice. Furthermore, CSC enhanced the suppressive activity of bone marrow-derived myeloid-derived suppressor cells towards proliferating T cells. In line with the occurrence of suppressor cell types such as regulatory T cells and myeloid-derived suppressor cells, transplanted syngeneic fibrosarcoma cells grew better in CSC mice than in controls, a process accompanied by pronounced angiogenesis and clustering of immature myeloid cells in the tumor tissue. In addition, tumor implantation after CSC reinforced the CSC-induced increase in myeloid-derived suppressor cells and regulatory T cell frequencies while the CSC-induced cellular changes eased off in mice without tumor. Together, our data suggest a role for suppressor cells such as regulatory T cells and myeloid-derived suppressor cells in the enhanced tumor growth after chronic psychosocial stress. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27391954/Induction_of_Suppressor_Cells_and_Increased_Tumor_Growth_following_Chronic_Psychosocial_Stress_in_Male_Mice_ L2 - https://dx.plos.org/10.1371/journal.pone.0159059 DB - PRIME DP - Unbound Medicine ER -