Tags

Type your tag names separated by a space and hit enter

Experimental study showed that adding fortifier and extra-hydrolysed proteins to preterm infant mothers' milk increased osmolality.
Acta Paediatr. 2016 Dec; 105(12):e555-e560.AP

Abstract

AIM

Measuring milk osmolality after adjustable fortification is clinically relevant, as values exceeding recommended safety thresholds might result in gastrointestinal consequences. The aim of this study was to evaluate the effect of four fortification levels and storage time on the osmolality of human milk.

METHODS

This was an experimental study using 71 spare samples of fresh breastmilk collected from 31 mothers of preterm infants. Osmolality was measured before and after adding commercial human milk fortifier containing dextrinomaltose and hydrolysed proteins at four different concentrations. Measurements were performed at various points during the 23 hours after fortification.

RESULTS

The mean basal osmolality of the 71 human milk samples was 296 ± 14 milliosmoles (mOsm)/kg, and these remained stable over a period of 23 hours. Just after fortification, the four fortified formulas showed higher osmolalities than the nonfortified human milk, ranging between 384 ± 14 and 486 ± 15 mOsm/kg, respectively (p < 0.01). This osmolality increased significantly from 20 minutes to 23 hours after fortification (p < 0.05).

CONCLUSION

Adding fortifier and extra-hydrolysed proteins to human preterm milk increased osmolality, and these osmolality levels also increased with time. We recommend evaluating the risk of hyperosmolality when a higher fortification level is needed, to avoid gastrointestinal problems.

Authors+Show Affiliations

Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain.Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain.Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain.Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain.Department of Neonatology, La Paz University Hospital, Madrid, Spain.Department of Neonatology, La Paz University Hospital, Madrid, Spain.Department of Neonatology, La Paz University Hospital, Madrid, Spain.Department of Neonatology, La Paz University Hospital, Madrid, Spain. Instituto de Salud Carlos III, Red de Salud Materno Infantil y Desarrollo-SAMID, Madrid, Spain. Department of Pediatrics, Autonomous University of Madrid, Madrid, Spain.Department of Neonatology, La Paz University Hospital, Madrid, Spain. Instituto de Salud Carlos III, Red de Salud Materno Infantil y Desarrollo-SAMID, Madrid, Spain. Department of Pediatrics, Autonomous University of Madrid, Madrid, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27392326

Citation

Rosas, R, et al. "Experimental Study Showed That Adding Fortifier and Extra-hydrolysed Proteins to Preterm Infant Mothers' Milk Increased Osmolality." Acta Paediatrica (Oslo, Norway : 1992), vol. 105, no. 12, 2016, pp. e555-e560.
Rosas R, Sanz MP, Fernández-Calle P, et al. Experimental study showed that adding fortifier and extra-hydrolysed proteins to preterm infant mothers' milk increased osmolality. Acta Paediatr. 2016;105(12):e555-e560.
Rosas, R., Sanz, M. P., Fernández-Calle, P., Alcaide, M. J., Montes, M. T., Pastrana, N., Segovia, C., Omeñaca, F., & Sáenz de Pipaón, M. (2016). Experimental study showed that adding fortifier and extra-hydrolysed proteins to preterm infant mothers' milk increased osmolality. Acta Paediatrica (Oslo, Norway : 1992), 105(12), e555-e560. https://doi.org/10.1111/apa.13522
Rosas R, et al. Experimental Study Showed That Adding Fortifier and Extra-hydrolysed Proteins to Preterm Infant Mothers' Milk Increased Osmolality. Acta Paediatr. 2016;105(12):e555-e560. PubMed PMID: 27392326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental study showed that adding fortifier and extra-hydrolysed proteins to preterm infant mothers' milk increased osmolality. AU - Rosas,R, AU - Sanz,M P, AU - Fernández-Calle,P, AU - Alcaide,M J, AU - Montes,M T, AU - Pastrana,N, AU - Segovia,C, AU - Omeñaca,F, AU - Sáenz de Pipaón,M, Y1 - 2016/08/05/ PY - 2016/01/26/received PY - 2016/04/04/revised PY - 2016/07/06/accepted PY - 2016/7/9/pubmed PY - 2017/3/30/medline PY - 2016/7/9/entrez KW - Extra protein supplement KW - Gastrointestinal problems KW - Human milk fortifier KW - Osmolality KW - Premature infant SP - e555 EP - e560 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 105 IS - 12 N2 - AIM: Measuring milk osmolality after adjustable fortification is clinically relevant, as values exceeding recommended safety thresholds might result in gastrointestinal consequences. The aim of this study was to evaluate the effect of four fortification levels and storage time on the osmolality of human milk. METHODS: This was an experimental study using 71 spare samples of fresh breastmilk collected from 31 mothers of preterm infants. Osmolality was measured before and after adding commercial human milk fortifier containing dextrinomaltose and hydrolysed proteins at four different concentrations. Measurements were performed at various points during the 23 hours after fortification. RESULTS: The mean basal osmolality of the 71 human milk samples was 296 ± 14 milliosmoles (mOsm)/kg, and these remained stable over a period of 23 hours. Just after fortification, the four fortified formulas showed higher osmolalities than the nonfortified human milk, ranging between 384 ± 14 and 486 ± 15 mOsm/kg, respectively (p < 0.01). This osmolality increased significantly from 20 minutes to 23 hours after fortification (p < 0.05). CONCLUSION: Adding fortifier and extra-hydrolysed proteins to human preterm milk increased osmolality, and these osmolality levels also increased with time. We recommend evaluating the risk of hyperosmolality when a higher fortification level is needed, to avoid gastrointestinal problems. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/27392326/Experimental_study_showed_that_adding_fortifier_and_extra_hydrolysed_proteins_to_preterm_infant_mothers'_milk_increased_osmolality_ L2 - https://doi.org/10.1111/apa.13522 DB - PRIME DP - Unbound Medicine ER -