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Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta-analysis of observational studies.
Obesity (Silver Spring) 2016; 24(8):1786-802O

Abstract

OBJECTIVE

Epidemiological studies have repeatedly investigated the association between excess body weight and the risk of biliary tract cancer with inconsistent results. The objective of this study was to quantitatively assess the associations between overweight and obesity and the risk of biliary tract cancer.

METHODS

A comprehensive search of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases up to August 2015 was conducted, and the reference lists of retrieved articles for additional relevant studies were manually searched.

RESULTS

Fourteen prospective cohort studies and 15 case-control studies were included in this meta-analysis. These studies included 11,448,397 participants (6,733 patients with gallbladder cancer [GBC] and 5,798 patients with extrahepatic bile duct cancer [EBDC]) with follow-up durations ranging from 5 to 23 years. Among overweight adults, the pooled RR was 1.17 (95% CI, 1.07-1.28) for GBC and 1.26 (95% CI, 1.14-1.39) for EBDC, and among people with obesity, the pooled RR was 1.62 (95% CI, 1.49-1.75) for GBC and 1.48 (95% CI, 1.21-1.81) for EBDC. Visual inspection of the funnel plots and the Begg's and the Egger's tests did not show enough evidence of publication bias.

CONCLUSIONS

Integrated evidence from this meta-analysis suggests that excess body weight is associated with a significantly increased risk of GBC and EBDC.

Authors+Show Affiliations

Department of Management, School of Economics and Management, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27392541

Citation

Li, Liqing, et al. "Overweight, Obesity and the Risk of Gallbladder and Extrahepatic Bile Duct Cancers: a Meta-analysis of Observational Studies." Obesity (Silver Spring, Md.), vol. 24, no. 8, 2016, pp. 1786-802.
Li L, Gan Y, Li W, et al. Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta-analysis of observational studies. Obesity (Silver Spring). 2016;24(8):1786-802.
Li, L., Gan, Y., Li, W., Wu, C., & Lu, Z. (2016). Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta-analysis of observational studies. Obesity (Silver Spring, Md.), 24(8), pp. 1786-802. doi:10.1002/oby.21505.
Li L, et al. Overweight, Obesity and the Risk of Gallbladder and Extrahepatic Bile Duct Cancers: a Meta-analysis of Observational Studies. Obesity (Silver Spring). 2016;24(8):1786-802. PubMed PMID: 27392541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta-analysis of observational studies. AU - Li,Liqing, AU - Gan,Yong, AU - Li,Wenzheng, AU - Wu,Chunmei, AU - Lu,Zuxun, Y1 - 2016/07/09/ PY - 2015/11/03/received PY - 2016/02/25/accepted PY - 2016/7/10/entrez PY - 2016/7/10/pubmed PY - 2017/6/18/medline SP - 1786 EP - 802 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 24 IS - 8 N2 - OBJECTIVE: Epidemiological studies have repeatedly investigated the association between excess body weight and the risk of biliary tract cancer with inconsistent results. The objective of this study was to quantitatively assess the associations between overweight and obesity and the risk of biliary tract cancer. METHODS: A comprehensive search of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases up to August 2015 was conducted, and the reference lists of retrieved articles for additional relevant studies were manually searched. RESULTS: Fourteen prospective cohort studies and 15 case-control studies were included in this meta-analysis. These studies included 11,448,397 participants (6,733 patients with gallbladder cancer [GBC] and 5,798 patients with extrahepatic bile duct cancer [EBDC]) with follow-up durations ranging from 5 to 23 years. Among overweight adults, the pooled RR was 1.17 (95% CI, 1.07-1.28) for GBC and 1.26 (95% CI, 1.14-1.39) for EBDC, and among people with obesity, the pooled RR was 1.62 (95% CI, 1.49-1.75) for GBC and 1.48 (95% CI, 1.21-1.81) for EBDC. Visual inspection of the funnel plots and the Begg's and the Egger's tests did not show enough evidence of publication bias. CONCLUSIONS: Integrated evidence from this meta-analysis suggests that excess body weight is associated with a significantly increased risk of GBC and EBDC. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/27392541/Overweight_obesity_and_the_risk_of_gallbladder_and_extrahepatic_bile_duct_cancers:_A_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1002/oby.21505 DB - PRIME DP - Unbound Medicine ER -