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Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus.
Med Vet Entomol. 2016 12; 30(4):377-382.MV

Abstract

The effects of combinations of the monoterpenes thymol and carvacrol and the phenylpropanoid eugenol in larvae of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) and Rhipicephalus sanguineus sensu lato (s.l.) (Acari: Ixodidae) were assessed by the larval packet test. The CompuSyn program was used to make qualitative assessments of the effects (synergistic, additive and antagonistic) of the associations. The effects of all combinations tested against R. microplus larvae were synergistic, with combination indices (CIs) <0.70. When tested against R. sanguineus, eight of the mixtures showed a synergistic effect (CI < 0.70); only the carvacrol + thymol mixture at LC50 presented a moderate synergistic effect, with CIs between 0.70-0.90. This study is the first to determine the effects of the interactions of these substances in the control of these two tick species. The combinations of carvacrol + thymol, carvacrol + eugenol and thymol + eugenol have synergistic effects in R. microplus and R. sanguineus s.l. larvae.

Authors+Show Affiliations

Programa de Pós-Graduação em Ciências Biológicas, Comportamento e Biologia Animal, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.Programa de Pós-Graduação em Biologia Animal, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Comportamento e Biologia Animal, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Comportamento e Biologia Animal, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.Departamento de Química, Instituto de Ciências Exatas da Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.Programa de Pós-Graduação em Ciências Biológicas, Comportamento e Biologia Animal, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil. caiosat@gmail.com. Programa de Pós-Graduação em Ciência Animal, Universidade Federal de Goiás, Goiânia, GO, Brazil. caiosat@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27392803

Citation

Araújo, L X., et al. "Synergism of Thymol, Carvacrol and Eugenol in Larvae of the Cattle Tick, Rhipicephalus Microplus, and Brown Dog Tick, Rhipicephalus Sanguineus." Medical and Veterinary Entomology, vol. 30, no. 4, 2016, pp. 377-382.
Araújo LX, Novato TP, Zeringota V, et al. Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus. Med Vet Entomol. 2016;30(4):377-382.
Araújo, L. X., Novato, T. P., Zeringota, V., Maturano, R., Melo, D., DA Silva, B. C., Daemon, E., DE Carvalho, M. G., & Monteiro, C. M. (2016). Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus. Medical and Veterinary Entomology, 30(4), 377-382. https://doi.org/10.1111/mve.12181
Araújo LX, et al. Synergism of Thymol, Carvacrol and Eugenol in Larvae of the Cattle Tick, Rhipicephalus Microplus, and Brown Dog Tick, Rhipicephalus Sanguineus. Med Vet Entomol. 2016;30(4):377-382. PubMed PMID: 27392803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus. AU - Araújo,L X, AU - Novato,T P L, AU - Zeringota,V, AU - Maturano,R, AU - Melo,D, AU - DA Silva,B C, AU - Daemon,E, AU - DE Carvalho,M G, AU - Monteiro,C M O, Y1 - 2016/07/09/ PY - 2016/01/29/received PY - 2016/03/20/revised PY - 2016/04/11/accepted PY - 2016/10/30/pubmed PY - 2017/9/19/medline PY - 2016/7/10/entrez KW - Compounds of plant origin KW - monoterpene KW - phenylpropanoid KW - tick control SP - 377 EP - 382 JF - Medical and veterinary entomology JO - Med. Vet. Entomol. VL - 30 IS - 4 N2 - The effects of combinations of the monoterpenes thymol and carvacrol and the phenylpropanoid eugenol in larvae of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) and Rhipicephalus sanguineus sensu lato (s.l.) (Acari: Ixodidae) were assessed by the larval packet test. The CompuSyn program was used to make qualitative assessments of the effects (synergistic, additive and antagonistic) of the associations. The effects of all combinations tested against R. microplus larvae were synergistic, with combination indices (CIs) <0.70. When tested against R. sanguineus, eight of the mixtures showed a synergistic effect (CI < 0.70); only the carvacrol + thymol mixture at LC50 presented a moderate synergistic effect, with CIs between 0.70-0.90. This study is the first to determine the effects of the interactions of these substances in the control of these two tick species. The combinations of carvacrol + thymol, carvacrol + eugenol and thymol + eugenol have synergistic effects in R. microplus and R. sanguineus s.l. larvae. SN - 1365-2915 UR - https://www.unboundmedicine.com/medline/citation/27392803/Synergism_of_thymol_carvacrol_and_eugenol_in_larvae_of_the_cattle_tick_Rhipicephalus_microplus_and_brown_dog_tick_Rhipicephalus_sanguineus_ L2 - https://doi.org/10.1111/mve.12181 DB - PRIME DP - Unbound Medicine ER -