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Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy.
Arch Virol. 2016 Oct; 161(10):2829-34.AV

Abstract

Hepatitis E virus (HEV) was detected in stools collected from wild boars in Italy, with an overall prevalence of 1.5 % (3/196). The sequence of a ~3.0-kb portion at the 3' end of the genome of one such strain, HEV/WB/P6-15/ITA, was determined. In the full-length ORF2, which encodes the capsid protein, the virus was genetically closest to wild boar and human HEV strains currently classified as genotype 3 subtype c. Interestingly, the 3' end of ORF2 of the WB/P6-15/ITA matched the 340-nucleotide (nt) sequence (94.0 % nt identity) of the human strain PeGe, identified in 2015 from a patient with acute hepatitis E in Genoa, Italy, suggesting that similar HEV strains are circulating in the same geographical setting in humans and animals.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.Faculty of Veterinary Medicine, Università Aldo Moro di Bari, Valenzano, Italy.Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy. bdimartino@unite.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27393602

Citation

Di Profio, Federica, et al. "Detection and Genetic Characterization of Hepatitis E Virus (HEV) Genotype 3 Subtype C in Wild Boars in Italy." Archives of Virology, vol. 161, no. 10, 2016, pp. 2829-34.
Di Profio F, Melegari I, Sarchese V, et al. Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy. Arch Virol. 2016;161(10):2829-34.
Di Profio, F., Melegari, I., Sarchese, V., Robetto, S., Marruchella, G., Bona, M. C., Orusa, R., Martella, V., Marsilio, F., & Di Martino, B. (2016). Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy. Archives of Virology, 161(10), 2829-34. https://doi.org/10.1007/s00705-016-2964-y
Di Profio F, et al. Detection and Genetic Characterization of Hepatitis E Virus (HEV) Genotype 3 Subtype C in Wild Boars in Italy. Arch Virol. 2016;161(10):2829-34. PubMed PMID: 27393602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy. AU - Di Profio,Federica, AU - Melegari,Irene, AU - Sarchese,Vittorio, AU - Robetto,Serena, AU - Marruchella,Giuseppe, AU - Bona,Maria Cristina, AU - Orusa,Riccardo, AU - Martella,Vito, AU - Marsilio,Fulvio, AU - Di Martino,Barbara, Y1 - 2016/07/08/ PY - 2016/04/05/received PY - 2016/07/01/accepted PY - 2016/7/10/entrez PY - 2016/7/10/pubmed PY - 2017/1/24/medline SP - 2829 EP - 34 JF - Archives of virology JO - Arch Virol VL - 161 IS - 10 N2 - Hepatitis E virus (HEV) was detected in stools collected from wild boars in Italy, with an overall prevalence of 1.5 % (3/196). The sequence of a ~3.0-kb portion at the 3' end of the genome of one such strain, HEV/WB/P6-15/ITA, was determined. In the full-length ORF2, which encodes the capsid protein, the virus was genetically closest to wild boar and human HEV strains currently classified as genotype 3 subtype c. Interestingly, the 3' end of ORF2 of the WB/P6-15/ITA matched the 340-nucleotide (nt) sequence (94.0 % nt identity) of the human strain PeGe, identified in 2015 from a patient with acute hepatitis E in Genoa, Italy, suggesting that similar HEV strains are circulating in the same geographical setting in humans and animals. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/27393602/Detection_and_genetic_characterization_of_hepatitis_E_virus__HEV__genotype_3_subtype_c_in_wild_boars_in_Italy_ L2 - https://dx.doi.org/10.1007/s00705-016-2964-y DB - PRIME DP - Unbound Medicine ER -