Type your tag names separated by a space and hit enter
Trans fatty acids and cholesterol levels: An evidence map of the available science.
High intakes of industrial trans fatty acids (iTFA) increase circulating low density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease (CHD) risk. Published data on iTFA and LDL-C, however, represent higher intake levels than the U.S. population currently consume. This study used state-of-the-art evidence mapping approaches to characterize the full body of literature on LDL-C and iTFA at low intake levels. A total of 32 independent clinical trials that included at least one intervention or control group with iTFA at ≤3%en were found. Findings indicated that a wide range of oils and interventions were used, limiting the ability to determine an isolated effect of iTFA intake. Few data points were found for iTFA at <3%en, with the majority of low-level exposures actually representing control group interventions containing non-partially hydrogenated (PHO) oils. Further, it appears that few dose-response data points are available to assess the relationship of low levels of iTFA, particularly from PHO exposure, and LDL-C. Therefore, limited evidence is available to determine the effect of iTFA at current consumption levels on CHD risk.
Biofortis Clinical Research, Addison, IL, USA. Electronic address: firstname.lastname@example.org.,
Biofortis Clinical Research, Addison, IL, USA.,
D & V Systematic Evidence Review Consulting, Bronx, NY, 10461, USA.,
ILSI North America (Formerly), The Sugar Association (Presently), Washington, DC, 20005, USA.
U.S. Department of Agriculture, Beltsville Human Nutrition Research Center, USA.
Meta-Analysis as Topic
Trans Fatty Acids
Pub Type(s)Journal Article