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Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis.
Hormones (Athens) 2016; 15(3):385-393H

Abstract

OBJECTIVE

The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Graves' disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD.

DESIGN

Our cross-sectional study included patients who visited a tertiary hospital for thyroid evaluation or follow-up. A total of 776 patients in whom serum 25-hydroxyvitamin D [25(OH)D], thyroid function, and anti-thyroid antibodies had been measured were analyzed retrospectively. Vitamin D insufficiency was defined as serum 25(OH)D level <75 nmol/L.

RESULTS

The prevalence of vitamin D insufficiency was significantly higher in the 369 patients with AITD than in the 407 without AITD (46.1% vs. 37.1%, p=0.011), and higher in the 221 patients with HT than in those with GD or non-AITD (48.9% vs. 41.9%, 37.1%, p=0.017). Among HT cases, patients with overt hypothyroidism had a significantly higher prevalence of vitamin D insufficiency (60.4% vs. 44.1%, 21.7%, 37.1%, respectively, p <0.001) and lower 25(OH)D levels (80.1 ± 47.7 vs. 99.34 ± 61.2, 110.3 ± 69.9, 99.6 ± 53.7 nmol/L, respectively, p=0.009) compared with those with euthyroidism and subclinical hypothyroidism or those without AITD. Serum 25(OH)D levels were significantly negatively correlated with serum thyroid stimulating hormone (TSH) levels after adjustment for age, sex, body mass index, and sampling season (r= -0.127, p=0.013).

CONCLUSION

Vitamin D insufficiency was associated with AITD and HT, especially overt hypothyroidism. Low serum vitamin D levels were independently associated with high serum TSH levels.

Authors+Show Affiliations

Division of Endocrinology, Department of Internal Medicine, Dankook University College of Medicine, 119 Dandae-ro Dongnam-gu Cheonan-si, Chungnam, 330-714, Republic of Korea. dh9070@hanmail.net. Department of Kinesiologic Medical Science, Graduate, Dankook University, Cheonan, 330-714, Republic of Korea. dh9070@hanmail.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27394703

Citation

Kim, Dohee. "Low Vitamin D Status Is Associated With Hypothyroid Hashimoto's Thyroiditis." Hormones (Athens, Greece), vol. 15, no. 3, 2016, pp. 385-393.
Kim D. Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens). 2016;15(3):385-393.
Kim, D. (2016). Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens, Greece), 15(3), pp. 385-393. doi:10.14310/horm.2002.1681.
Kim D. Low Vitamin D Status Is Associated With Hypothyroid Hashimoto's Thyroiditis. Hormones (Athens). 2016;15(3):385-393. PubMed PMID: 27394703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. A1 - Kim,Dohee, PY - 2015/06/18/received PY - 2016/03/23/accepted PY - 2016/7/11/pubmed PY - 2017/4/18/medline PY - 2016/7/11/entrez SP - 385 EP - 393 JF - Hormones (Athens, Greece) JO - Hormones (Athens) VL - 15 IS - 3 N2 - OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Graves' disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients who visited a tertiary hospital for thyroid evaluation or follow-up. A total of 776 patients in whom serum 25-hydroxyvitamin D [25(OH)D], thyroid function, and anti-thyroid antibodies had been measured were analyzed retrospectively. Vitamin D insufficiency was defined as serum 25(OH)D level <75 nmol/L. RESULTS: The prevalence of vitamin D insufficiency was significantly higher in the 369 patients with AITD than in the 407 without AITD (46.1% vs. 37.1%, p=0.011), and higher in the 221 patients with HT than in those with GD or non-AITD (48.9% vs. 41.9%, 37.1%, p=0.017). Among HT cases, patients with overt hypothyroidism had a significantly higher prevalence of vitamin D insufficiency (60.4% vs. 44.1%, 21.7%, 37.1%, respectively, p <0.001) and lower 25(OH)D levels (80.1 ± 47.7 vs. 99.34 ± 61.2, 110.3 ± 69.9, 99.6 ± 53.7 nmol/L, respectively, p=0.009) compared with those with euthyroidism and subclinical hypothyroidism or those without AITD. Serum 25(OH)D levels were significantly negatively correlated with serum thyroid stimulating hormone (TSH) levels after adjustment for age, sex, body mass index, and sampling season (r= -0.127, p=0.013). CONCLUSION: Vitamin D insufficiency was associated with AITD and HT, especially overt hypothyroidism. Low serum vitamin D levels were independently associated with high serum TSH levels. SN - 2520-8721 UR - https://www.unboundmedicine.com/medline/citation/27394703/Low_vitamin_D_status_is_associated_with_hypothyroid_Hashimoto's_thyroiditis_ L2 - http://hormones.gr/preview.php?c_id=8637 DB - PRIME DP - Unbound Medicine ER -