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[Prevention of Alzheimer's Disease and Nutrients].
Brain Nerve. 2016 Jul; 68(7):809-17.BN

Abstract

The dietary recommendations for the prevention and management of Alzheimer's disease (AD), are the Mediterranean diet and the Japanese-style diet, both of which contain well-balanced nutrients from fish and vegetables. These diets are rich in vitamin E, carotenes, antioxidant flavonoids, vitamin B12, folate, and n-3PUFA. According to recent review supplementation of folate and vitamin E may protect against elderly people's cognitive decline when the serum folate is <12 nmol/L or the vitamin E intake is <6.1 mg/day. Another nutritional topic with regard to dementia and diet is the association of type-2 diabetes and hyperinsulinemia with AD. Expression array data of the brain tissue of AD patients in the Hisayama study strongly suggests a disturbance in insulin signaling in the AD brain. The dysfunction of insulin signaling could directly lead to disrupted glucose utilization in the AD brain. Instead of improperly utilized glucose, the medium chain triglyceride ketone bodies can be an alternative energy resource for the AD brain. In conclusion, the dietary recommendations for the prevention and management of AD are a high consumption of fish, vegetables, and low glycemic index fruits; a moderate amount of meat and dairy products; and a lower amount of carbohydrates and refined sugar.

Authors+Show Affiliations

Department of Neurology, International University of Health and Wellfare Hospital.

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

27395465

Citation

Otsuka, Mieko. "[Prevention of Alzheimer's Disease and Nutrients]." Brain and Nerve = Shinkei Kenkyu No Shinpo, vol. 68, no. 7, 2016, pp. 809-17.
Otsuka M. [Prevention of Alzheimer's Disease and Nutrients]. Brain Nerve. 2016;68(7):809-17.
Otsuka, M. (2016). [Prevention of Alzheimer's Disease and Nutrients]. Brain and Nerve = Shinkei Kenkyu No Shinpo, 68(7), 809-17. https://doi.org/10.11477/mf.1416200513
Otsuka M. [Prevention of Alzheimer's Disease and Nutrients]. Brain Nerve. 2016;68(7):809-17. PubMed PMID: 27395465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevention of Alzheimer's Disease and Nutrients]. A1 - Otsuka,Mieko, PY - 2016/7/11/entrez PY - 2016/7/11/pubmed PY - 2016/12/15/medline SP - 809 EP - 17 JF - Brain and nerve = Shinkei kenkyu no shinpo JO - Brain Nerve VL - 68 IS - 7 N2 - The dietary recommendations for the prevention and management of Alzheimer's disease (AD), are the Mediterranean diet and the Japanese-style diet, both of which contain well-balanced nutrients from fish and vegetables. These diets are rich in vitamin E, carotenes, antioxidant flavonoids, vitamin B12, folate, and n-3PUFA. According to recent review supplementation of folate and vitamin E may protect against elderly people's cognitive decline when the serum folate is <12 nmol/L or the vitamin E intake is <6.1 mg/day. Another nutritional topic with regard to dementia and diet is the association of type-2 diabetes and hyperinsulinemia with AD. Expression array data of the brain tissue of AD patients in the Hisayama study strongly suggests a disturbance in insulin signaling in the AD brain. The dysfunction of insulin signaling could directly lead to disrupted glucose utilization in the AD brain. Instead of improperly utilized glucose, the medium chain triglyceride ketone bodies can be an alternative energy resource for the AD brain. In conclusion, the dietary recommendations for the prevention and management of AD are a high consumption of fish, vegetables, and low glycemic index fruits; a moderate amount of meat and dairy products; and a lower amount of carbohydrates and refined sugar. SN - 1881-6096 UR - https://www.unboundmedicine.com/medline/citation/27395465/[Prevention_of_Alzheimer's_Disease_and_Nutrients]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&amp;rft.issn=1881-6096&amp;rft.volume=68&amp;rft.issue=7&amp;rft.spage=809 DB - PRIME DP - Unbound Medicine ER -
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