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Local production of IgG to pneumococcal C-polysaccharide in upper airway secretions from children with recurrent acute otitis media.
Microb Pathog. 1989 Mar; 6(3):183-91.MP

Abstract

Antibodies against C-polysaccharide (C-Ps), a common cell wall component of all pneumococci, may be of importance for the elimination of decaying pneumococci. By means of ELISA with phenylated C-Ps, anti-C-Ps IgG was measured in samples of plasma and upper airway secretions from otitis-prone children (OP), children with fewer episodes of recurrent acute otitis media (rAOM), and children with no previous history of AOM, but suffering from secretory otitis media (SOM). All children were free from acute illness at the time of sampling. No statistically significant differences of anti-C-Ps IgG in plasma or in nasopharyngeal secretions (NPS) were found between any of the groups. Based on calculations of the correlation between levels of anti-C-Ps IgG in plasma and NPS, and of the transudation ratios of anti-C-Ps IgG, total IgG, and albumin from plasma to NPS, we suggest that a significant amount of the anti-C-Ps IgG in NPS must be locally produced. The additional finding that OP children had significantly higher levels of anti-C-Ps IgG in their middle ear effusions (MEE) than SOM children points in the same direction. Anti-C-Ps IgA and IgM were detected in very low concentrations in plasma and secretion samples.

Authors+Show Affiliations

Sørensen CH
Department of Otolaryngology, Gentofte University Hospital, Hellerup, Denmark.
Sørensen UB
No affiliation info available
Henrichsen J
No affiliation info available

MeSH

Acute DiseaseAntigens, BacterialChildChild, PreschoolEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GInfantNasopharynxOtitis MediaOtitis Media with EffusionOtitis Media, SuppurativePolysaccharides, BacterialRecurrenceStreptococcus pneumoniae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2739559

Citation

Sørensen, C H., et al. "Local Production of IgG to Pneumococcal C-polysaccharide in Upper Airway Secretions From Children With Recurrent Acute Otitis Media." Microbial Pathogenesis, vol. 6, no. 3, 1989, pp. 183-91.
Sørensen CH, Sørensen UB, Henrichsen J. Local production of IgG to pneumococcal C-polysaccharide in upper airway secretions from children with recurrent acute otitis media. Microb Pathog. 1989;6(3):183-91.
Sørensen, C. H., Sørensen, U. B., & Henrichsen, J. (1989). Local production of IgG to pneumococcal C-polysaccharide in upper airway secretions from children with recurrent acute otitis media. Microbial Pathogenesis, 6(3), 183-91.
Sørensen CH, Sørensen UB, Henrichsen J. Local Production of IgG to Pneumococcal C-polysaccharide in Upper Airway Secretions From Children With Recurrent Acute Otitis Media. Microb Pathog. 1989;6(3):183-91. PubMed PMID: 2739559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local production of IgG to pneumococcal C-polysaccharide in upper airway secretions from children with recurrent acute otitis media. AU - Sørensen,C H, AU - Sørensen,U B, AU - Henrichsen,J, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 183 EP - 91 JF - Microbial pathogenesis JO - Microb Pathog VL - 6 IS - 3 N2 - Antibodies against C-polysaccharide (C-Ps), a common cell wall component of all pneumococci, may be of importance for the elimination of decaying pneumococci. By means of ELISA with phenylated C-Ps, anti-C-Ps IgG was measured in samples of plasma and upper airway secretions from otitis-prone children (OP), children with fewer episodes of recurrent acute otitis media (rAOM), and children with no previous history of AOM, but suffering from secretory otitis media (SOM). All children were free from acute illness at the time of sampling. No statistically significant differences of anti-C-Ps IgG in plasma or in nasopharyngeal secretions (NPS) were found between any of the groups. Based on calculations of the correlation between levels of anti-C-Ps IgG in plasma and NPS, and of the transudation ratios of anti-C-Ps IgG, total IgG, and albumin from plasma to NPS, we suggest that a significant amount of the anti-C-Ps IgG in NPS must be locally produced. The additional finding that OP children had significantly higher levels of anti-C-Ps IgG in their middle ear effusions (MEE) than SOM children points in the same direction. Anti-C-Ps IgA and IgM were detected in very low concentrations in plasma and secretion samples. SN - 0882-4010 UR - https://www.unboundmedicine.com/medline/citation/2739559/Local_production_of_IgG_to_pneumococcal_C_polysaccharide_in_upper_airway_secretions_from_children_with_recurrent_acute_otitis_media_ DB - PRIME DP - Unbound Medicine ER -