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Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking.
Metallomics. 2016 09 01; 8(9):831-9.M

Abstract

Copper is an essential metal ion that provides catalytic function to numerous enzymes and also regulates neurotransmission and intracellular signaling. Conversely, a deficiency or excess of copper can cause chronic disease in humans. Menkes and Wilson disease are two rare heritable disorders of copper transport that are characterized by copper deficiency and copper overload, respectively. Changes to copper status are also a common feature of several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). In the case of AD, which is characterized by brain copper depletion, changes in the distribution of copper has been linked with various aspects of the disease process; protein aggregation, defective protein degradation, oxidative stress, inflammation and mitochondrial dysfunction. Although AD is a multifactorial disease that is likely caused by a breakdown in multiple cellular pathways, copper and other metal ions such as iron and zinc play a central role in many of these cellular processes. Pioneering work by researchers who have studied relatively rare copper transport diseases has shed light on potential metal ion related disease mechanisms in other forms of neurodegeneration such as AD.

Authors+Show Affiliations

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria 3010, Australia. carlos.opazo@florey.edu.au.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27397642

Citation

Greenough, M A., et al. "Metallo-pathways to Alzheimer's Disease: Lessons From Genetic Disorders of Copper Trafficking." Metallomics : Integrated Biometal Science, vol. 8, no. 9, 2016, pp. 831-9.
Greenough MA, Ramírez Munoz A, Bush AI, et al. Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking. Metallomics. 2016;8(9):831-9.
Greenough, M. A., Ramírez Munoz, A., Bush, A. I., & Opazo, C. M. (2016). Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking. Metallomics : Integrated Biometal Science, 8(9), 831-9. https://doi.org/10.1039/c6mt00095a
Greenough MA, et al. Metallo-pathways to Alzheimer's Disease: Lessons From Genetic Disorders of Copper Trafficking. Metallomics. 2016 09 1;8(9):831-9. PubMed PMID: 27397642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking. AU - Greenough,M A, AU - Ramírez Munoz,A, AU - Bush,A I, AU - Opazo,C M, Y1 - 2016/07/11/ PY - 2016/7/12/entrez PY - 2016/7/12/pubmed PY - 2017/12/12/medline SP - 831 EP - 9 JF - Metallomics : integrated biometal science JO - Metallomics VL - 8 IS - 9 N2 - Copper is an essential metal ion that provides catalytic function to numerous enzymes and also regulates neurotransmission and intracellular signaling. Conversely, a deficiency or excess of copper can cause chronic disease in humans. Menkes and Wilson disease are two rare heritable disorders of copper transport that are characterized by copper deficiency and copper overload, respectively. Changes to copper status are also a common feature of several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). In the case of AD, which is characterized by brain copper depletion, changes in the distribution of copper has been linked with various aspects of the disease process; protein aggregation, defective protein degradation, oxidative stress, inflammation and mitochondrial dysfunction. Although AD is a multifactorial disease that is likely caused by a breakdown in multiple cellular pathways, copper and other metal ions such as iron and zinc play a central role in many of these cellular processes. Pioneering work by researchers who have studied relatively rare copper transport diseases has shed light on potential metal ion related disease mechanisms in other forms of neurodegeneration such as AD. SN - 1756-591X UR - https://www.unboundmedicine.com/medline/citation/27397642/Metallo_pathways_to_Alzheimer's_disease:_lessons_from_genetic_disorders_of_copper_trafficking_ L2 - https://doi.org/10.1039/c6mt00095a DB - PRIME DP - Unbound Medicine ER -