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The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis.
Surgery 2016; 160(5):1189-1201S

Abstract

BACKGROUND

Preoperative physical fitness is predictive of postoperative outcome. Patients with lesser aerobic capacity are at greater risk of postoperative complications, longer hospital stays, and mortality. Prehabilitation may improve physical fitness, but it is unknown whether enhanced fitness translates to an improvement in postoperative outcome.

METHODS

This systematic review and meta-analysis aimed to assess the ability of prehabilitation to influence postoperative outcome after intra-abdominal operations. Randomized controlled trials with at least 1 group undergoing a preoperative exercise intervention/prehabilitation were included. The following databases were searched: AMED, CINAHL, EMBASE, PubMed/Medline, and The Cochrane Library. Data extracted from 9 full-articles included author(s), population demographics, type of operation, postoperative measures of outcome, and type of treatment of the prehabilitation and control groups. Methodologic quality was assessed using GRADEpro, and the Cochrane risk of bias tool was used to measure study bias.

RESULTS

Prehabilitation consisting of inspiratory muscle training, aerobic exercise, and/or resistance training can decrease all types of postoperative complications after intra-abdominal operations (odds ratio: 0.59, 95% confidence interval: 0.38-0.91, P = .03). It is unclear from our meta-analysis whether prehabilitation can decrease postoperative length of stay, because the number of studies that examined length of stay was small (n = 4). No postoperative mortality was reported in any study, and conclusions could not be drawn on the ability of exercise to influence operative mortality. The methodologic quality of studies was, however, "very low."

CONCLUSION

Prehabilitation appears to be beneficial in decreasing the incidence of postoperative complications; however, more high-quality studies are needed to validate its use in the preoperative setting.

Authors+Show Affiliations

Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, Dublin, Ireland. Electronic address: moranj2@tcd.ie.Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, Dublin, Ireland.Department of Colorectal Surgery, St. James's Hospital, Dublin, Ireland.Department of Colorectal Surgery, St. James's Hospital, Dublin, Ireland.John Strearne Medical Library, Trinity College Dublin, Trinity Centre for Health Sciences, Dublin, Ireland.Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, Dublin, Ireland.Department of Anaesthesia and Intensive Care, St. James's Hospital, Dublin, Ireland.Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, Dublin, Ireland.

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27397681

Citation

Moran, Jonathan, et al. "The Ability of Prehabilitation to Influence Postoperative Outcome After Intra-abdominal Operation: a Systematic Review and Meta-analysis." Surgery, vol. 160, no. 5, 2016, pp. 1189-1201.
Moran J, Guinan E, McCormick P, et al. The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis. Surgery. 2016;160(5):1189-1201.
Moran, J., Guinan, E., McCormick, P., Larkin, J., Mockler, D., Hussey, J., ... Wilson, F. (2016). The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis. Surgery, 160(5), pp. 1189-1201. doi:10.1016/j.surg.2016.05.014.
Moran J, et al. The Ability of Prehabilitation to Influence Postoperative Outcome After Intra-abdominal Operation: a Systematic Review and Meta-analysis. Surgery. 2016;160(5):1189-1201. PubMed PMID: 27397681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis. AU - Moran,Jonathan, AU - Guinan,Emer, AU - McCormick,Paul, AU - Larkin,John, AU - Mockler,David, AU - Hussey,Juliette, AU - Moriarty,Jeanne, AU - Wilson,Fiona, Y1 - 2016/07/08/ PY - 2016/01/11/received PY - 2016/04/11/revised PY - 2016/05/05/accepted PY - 2016/10/30/pubmed PY - 2017/7/1/medline PY - 2016/7/12/entrez SP - 1189 EP - 1201 JF - Surgery JO - Surgery VL - 160 IS - 5 N2 - BACKGROUND: Preoperative physical fitness is predictive of postoperative outcome. Patients with lesser aerobic capacity are at greater risk of postoperative complications, longer hospital stays, and mortality. Prehabilitation may improve physical fitness, but it is unknown whether enhanced fitness translates to an improvement in postoperative outcome. METHODS: This systematic review and meta-analysis aimed to assess the ability of prehabilitation to influence postoperative outcome after intra-abdominal operations. Randomized controlled trials with at least 1 group undergoing a preoperative exercise intervention/prehabilitation were included. The following databases were searched: AMED, CINAHL, EMBASE, PubMed/Medline, and The Cochrane Library. Data extracted from 9 full-articles included author(s), population demographics, type of operation, postoperative measures of outcome, and type of treatment of the prehabilitation and control groups. Methodologic quality was assessed using GRADEpro, and the Cochrane risk of bias tool was used to measure study bias. RESULTS: Prehabilitation consisting of inspiratory muscle training, aerobic exercise, and/or resistance training can decrease all types of postoperative complications after intra-abdominal operations (odds ratio: 0.59, 95% confidence interval: 0.38-0.91, P = .03). It is unclear from our meta-analysis whether prehabilitation can decrease postoperative length of stay, because the number of studies that examined length of stay was small (n = 4). No postoperative mortality was reported in any study, and conclusions could not be drawn on the ability of exercise to influence operative mortality. The methodologic quality of studies was, however, "very low." CONCLUSION: Prehabilitation appears to be beneficial in decreasing the incidence of postoperative complications; however, more high-quality studies are needed to validate its use in the preoperative setting. SN - 1532-7361 UR - https://www.unboundmedicine.com/medline/citation/27397681/The_ability_of_prehabilitation_to_influence_postoperative_outcome_after_intra_abdominal_operation:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6060(16)30152-0 DB - PRIME DP - Unbound Medicine ER -