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Placental Weight in Pregnant Women with Type 1 Diabetes Mellitus: The Association with Fetal Growth.
Am J Perinatol. 2016 11; 33(13):1255-1261.AJ

Abstract

Objective To determine the association between placental weight (PW) and large for gestational age (LGA) in women with type 1 diabetes mellitus (T1DM) and whether glycemic control modifies the association. Study Design In a retrospective analysis of a cohort of women with T1DM, poor glycemic control was defined as glycohemoglobin A1(HbA1)≥ 8.5% (≥2 standard deviations [SD] above mean), and LGA as birth weight > 90th percentile, according to gestation, race, and sex. Multivariable logistic regression was used for analysis. Stratified analyses (HbA1 < 8.5% vs. HbA1 ≥ 8.5%) assessed the role of glycemic control on association between PW and LGA. Results PW in 302 pregnancies was positively associated with LGA (first vs. fourth quartile of PW; odds ratio [OR] = 9.56; 95% confidence interval [CI]: 4.14-22.08). Association varied significantly by glycemic control in the first trimester, but not in the second and third trimesters. For women with first trimester HbA1 concentration < 8.5%, there was no statistically significant association; however, with HbA1 ≥ 8.5%, there was a strong association (OR = 13.40, 95% CI: 3.31, 54.27). Conclusion There was a significant positive association between PW and LGA in infants of women with T1DM, particularly evident in pregnancies with poor glycemic control during the first trimester, highlighting the importance of achieving good glycemic control early in gestation.

Authors+Show Affiliations

Department of Biological Sciences, Loyola University, Chicago, Illinois.Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.MedStar Washington Hospital Center, Washington, District of Columbia.Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27398699

Citation

Mehta, Supal, et al. "Placental Weight in Pregnant Women With Type 1 Diabetes Mellitus: the Association With Fetal Growth." American Journal of Perinatology, vol. 33, no. 13, 2016, pp. 1255-1261.
Mehta S, Khoury J, Miodovnik M, et al. Placental Weight in Pregnant Women with Type 1 Diabetes Mellitus: The Association with Fetal Growth. Am J Perinatol. 2016;33(13):1255-1261.
Mehta, S., Khoury, J., Miodovnik, M., Kawakita, T., Ehrlich, S., & Bowers, K. (2016). Placental Weight in Pregnant Women with Type 1 Diabetes Mellitus: The Association with Fetal Growth. American Journal of Perinatology, 33(13), 1255-1261.
Mehta S, et al. Placental Weight in Pregnant Women With Type 1 Diabetes Mellitus: the Association With Fetal Growth. Am J Perinatol. 2016;33(13):1255-1261. PubMed PMID: 27398699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental Weight in Pregnant Women with Type 1 Diabetes Mellitus: The Association with Fetal Growth. AU - Mehta,Supal, AU - Khoury,Jane, AU - Miodovnik,Menachem, AU - Kawakita,Tetsuya, AU - Ehrlich,Shelley, AU - Bowers,Katherine, Y1 - 2016/07/11/ PY - 2016/10/21/pubmed PY - 2018/1/10/medline PY - 2016/7/12/entrez SP - 1255 EP - 1261 JF - American journal of perinatology JO - Am J Perinatol VL - 33 IS - 13 N2 - Objective To determine the association between placental weight (PW) and large for gestational age (LGA) in women with type 1 diabetes mellitus (T1DM) and whether glycemic control modifies the association. Study Design In a retrospective analysis of a cohort of women with T1DM, poor glycemic control was defined as glycohemoglobin A1(HbA1)≥ 8.5% (≥2 standard deviations [SD] above mean), and LGA as birth weight > 90th percentile, according to gestation, race, and sex. Multivariable logistic regression was used for analysis. Stratified analyses (HbA1 < 8.5% vs. HbA1 ≥ 8.5%) assessed the role of glycemic control on association between PW and LGA. Results PW in 302 pregnancies was positively associated with LGA (first vs. fourth quartile of PW; odds ratio [OR] = 9.56; 95% confidence interval [CI]: 4.14-22.08). Association varied significantly by glycemic control in the first trimester, but not in the second and third trimesters. For women with first trimester HbA1 concentration < 8.5%, there was no statistically significant association; however, with HbA1 ≥ 8.5%, there was a strong association (OR = 13.40, 95% CI: 3.31, 54.27). Conclusion There was a significant positive association between PW and LGA in infants of women with T1DM, particularly evident in pregnancies with poor glycemic control during the first trimester, highlighting the importance of achieving good glycemic control early in gestation. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/27398699/Placental_Weight_in_Pregnant_Women_with_Type_1_Diabetes_Mellitus:_The_Association_with_Fetal_Growth_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0036-1585055 DB - PRIME DP - Unbound Medicine ER -