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Endometriosis Might Be Inversely Associated with Developing Chronic Kidney Disease: A Population-Based Cohort Study in Taiwan.
Int J Mol Sci 2016; 17(7)IJ

Abstract

This study was conducted to determine the risk of chronic kidney disease (CKD) among women with endometriosis in Taiwan. We conducted a retrospective cohort study using the National Health Insurance Research Database of Taiwan. A total of 27,973 women with a diagnosis of endometriosis and 27,973 multivariable-matched controls (1:1) from 2000 to 2010 were selected. Cox regression and computed hazard ratios (HR) with 95% confidence intervals (95% CI) were used to determine the risk of CKD among women with endometriosis. The incidence rates (IR, per 10,000 person-years) of CKD among women with and without endometriosis were 4.64 and 7.01, respectively, with a significantly decreased risk of CKD (crude HR 0.65, 95% CI 0.53-0.81; adjusted HR 0.69, 95% CI 0.56-0.86) among women with endometriosis. The IR of CKD progressively increased with age, but the trend of lower CKD risk among women with endometriosis was consistent. However, the lower risk of CKD in women with endometriosis was no longer statistically significant after adjusting for menopausal status (adjusted HR 0.85, 95% CI 0.65-1.10). The results suggest that endometriosis is inversely associated with CKD, but this effect was mediated by menopause. The possible mechanism of this association is worthy of further evaluation.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Yang-Ming University Hospital, Ilan 260, Taiwan. benshianhuang@gmail.com. Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.Department of Nursing, Oriental Institute of Technology, New Taipei City 220, Taiwan. kcw@mail.oit.edu.tw.Institute of Public Health, National Yang-Ming University, Taipei 112, Taiwan. syhuang@ym.edu.tw.Institute of Public Health, National Yang-Ming University, Taipei 112, Taiwan. cyguo@ym.edu.tw.Institute of Public Health, National Yang-Ming University, Taipei 112, Taiwan. yjchou@ym.edu.tw.Biostatics Task Force, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 112, Taiwan. sweethsin509@gmail.com.Department of Family Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan. tjchen@vghtpe.gov.tw.Department of Nursing, Oriental Institute of Technology, New Taipei City 220, Taiwan. johnweiwang@gmail.com. Department of Medicine, Cheng-Hsin General Hospital, Taipei 112, Taiwan. johnweiwang@gmail.com.Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. phwang@vghtpe.gov.tw. Department of Medical Research, China Medical University Hospital, Taichung 440, Taiwan. phwang@vghtpe.gov.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27399682

Citation

Huang, Ben-Shian, et al. "Endometriosis Might Be Inversely Associated With Developing Chronic Kidney Disease: a Population-Based Cohort Study in Taiwan." International Journal of Molecular Sciences, vol. 17, no. 7, 2016.
Huang BS, Chang WH, Wang KC, et al. Endometriosis Might Be Inversely Associated with Developing Chronic Kidney Disease: A Population-Based Cohort Study in Taiwan. Int J Mol Sci. 2016;17(7).
Huang, B. S., Chang, W. H., Wang, K. C., Huang, N., Guo, C. Y., Chou, Y. J., ... Wang, P. H. (2016). Endometriosis Might Be Inversely Associated with Developing Chronic Kidney Disease: A Population-Based Cohort Study in Taiwan. International Journal of Molecular Sciences, 17(7), doi:10.3390/ijms17071079.
Huang BS, et al. Endometriosis Might Be Inversely Associated With Developing Chronic Kidney Disease: a Population-Based Cohort Study in Taiwan. Int J Mol Sci. 2016 Jul 7;17(7) PubMed PMID: 27399682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endometriosis Might Be Inversely Associated with Developing Chronic Kidney Disease: A Population-Based Cohort Study in Taiwan. AU - Huang,Ben-Shian, AU - Chang,Wen-Hsun, AU - Wang,Kuan-Chin, AU - Huang,Nicole, AU - Guo,Chao-Yu, AU - Chou,Yiing-Jen, AU - Huang,Hsin-Yi, AU - Chen,Tzeng-Ji, AU - Lee,Wen-Ling, AU - Wang,Peng-Hui, Y1 - 2016/07/07/ PY - 2016/03/30/received PY - 2016/06/20/revised PY - 2016/06/28/accepted PY - 2016/7/12/entrez PY - 2016/7/12/pubmed PY - 2017/3/24/medline KW - chronic kidney disease KW - cohort study KW - endometriosis KW - epidemiology KW - gender KW - menopause JF - International journal of molecular sciences JO - Int J Mol Sci VL - 17 IS - 7 N2 - This study was conducted to determine the risk of chronic kidney disease (CKD) among women with endometriosis in Taiwan. We conducted a retrospective cohort study using the National Health Insurance Research Database of Taiwan. A total of 27,973 women with a diagnosis of endometriosis and 27,973 multivariable-matched controls (1:1) from 2000 to 2010 were selected. Cox regression and computed hazard ratios (HR) with 95% confidence intervals (95% CI) were used to determine the risk of CKD among women with endometriosis. The incidence rates (IR, per 10,000 person-years) of CKD among women with and without endometriosis were 4.64 and 7.01, respectively, with a significantly decreased risk of CKD (crude HR 0.65, 95% CI 0.53-0.81; adjusted HR 0.69, 95% CI 0.56-0.86) among women with endometriosis. The IR of CKD progressively increased with age, but the trend of lower CKD risk among women with endometriosis was consistent. However, the lower risk of CKD in women with endometriosis was no longer statistically significant after adjusting for menopausal status (adjusted HR 0.85, 95% CI 0.65-1.10). The results suggest that endometriosis is inversely associated with CKD, but this effect was mediated by menopause. The possible mechanism of this association is worthy of further evaluation. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/27399682/Endometriosis_Might_Be_Inversely_Associated_with_Developing_Chronic_Kidney_Disease:_A_Population_Based_Cohort_Study_in_Taiwan_ L2 - http://www.mdpi.com/resolver?pii=ijms17071079 DB - PRIME DP - Unbound Medicine ER -