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Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis.
BMJ Open. 2016 07 08; 6(7):e009809.BO

Abstract

OBJECTIVES

To examine the associations of coffee consumption with the serum uric acid (SUA) level, hyperuricaemia (HU) and gout.

DESIGN

Systematic review and meta-analysis.

DATA SOURCES AND STUDY ELIGIBILITY CRITERIA

A comprehensive literature search up to April 2015, using PubMed and EMBASE databases, was conducted to identify the observational researches that examined the associations of coffee consumption with the SUA level, HU and gout. The standard mean difference (SMD), OR, relative risk (RR) and their corresponding 95% CIs for the highest and the lowest categories of coffee intake were determined.

RESULTS

A total of 11 observational studies (6 cross-sectional, 3 cohort and 2 case-control studies) were included in this systematic review and meta-analysis. The combined SMD suggested that there was no significant difference between the highest and the lowest coffee intake categories in terms of the SUA level (SMD=-0.09, 95% CI -0.23 to 0.05; p=0.21). Meanwhile, the overall multivariable adjusted OR for HU showed no significant difference between the highest and the lowest coffee intake categories (OR=0.84, 95% CI 0.65 to 1.09; p=0.20). However, the overall multivariable adjusted RR for gout showed a significant inverse association between coffee consumption and the incidence of gout (RR=0.43, 95% CI 0.31 to 0.59, p<0.001).

CONCLUSIONS

Current evidences are insufficient to validate the association between coffee consumption and a lower risk of HU. Owing to the limited number of studies, the available data show that coffee consumption may be associated with a lower risk of incident gout. Further well-designed prospective researches and randomised controlled trials are therefore needed to elaborate on these issues.

Links

Authors+Show Affiliations

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

MeSH

CoffeeGoutHumansHyperuricemiaMultivariate AnalysisOdds RatioProtective Factors

Pub Type(s)

Journal Article

Meta-Analysis

Review

Systematic Review

Language

eng

PubMed ID

27401353

Citation

Zhang, Yi, et al. "Is Coffee Consumption Associated With a Lower Risk of Hyperuricaemia or Gout? a Systematic Review and Meta-analysis." BMJ Open, vol. 6, no. 7, 2016, pp. e009809.

Zhang Y, Yang T, Zeng C, et al. Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis. BMJ Open. 2016;6(7):e009809.

Zhang, Y., Yang, T., Zeng, C., Wei, J., Li, H., Xiong, Y. L., Yang, Y., Ding, X., & Lei, G. (2016). Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis. BMJ Open, 6(7), e009809. https://doi.org/10.1136/bmjopen-2015-009809

Zhang Y, et al. Is Coffee Consumption Associated With a Lower Risk of Hyperuricaemia or Gout? a Systematic Review and Meta-analysis. BMJ Open. 2016 07 8;6(7):e009809. PubMed PMID: 27401353.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis. AU - Zhang,Yi, AU - Yang,Tuo, AU - Zeng,Chao, AU - Wei,Jie, AU - Li,Hui, AU - Xiong,Yi-Lin, AU - Yang,Ye, AU - Ding,Xiang, AU - Lei,Guanghua, Y1 - 2016/07/08/ PY - 2016/7/13/entrez PY - 2016/7/13/pubmed PY - 2017/12/6/medline KW - Coffee KW - Gout KW - Hyperuricemia KW - Serum uric acid KW - Systematic review and meta-analysis SP - e009809 EP - e009809 JF - BMJ open JO - BMJ Open VL - 6 IS - 7 N2 - OBJECTIVES: To examine the associations of coffee consumption with the serum uric acid (SUA) level, hyperuricaemia (HU) and gout. DESIGN: Systematic review and meta-analysis. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: A comprehensive literature search up to April 2015, using PubMed and EMBASE databases, was conducted to identify the observational researches that examined the associations of coffee consumption with the SUA level, HU and gout. The standard mean difference (SMD), OR, relative risk (RR) and their corresponding 95% CIs for the highest and the lowest categories of coffee intake were determined. RESULTS: A total of 11 observational studies (6 cross-sectional, 3 cohort and 2 case-control studies) were included in this systematic review and meta-analysis. The combined SMD suggested that there was no significant difference between the highest and the lowest coffee intake categories in terms of the SUA level (SMD=-0.09, 95% CI -0.23 to 0.05; p=0.21). Meanwhile, the overall multivariable adjusted OR for HU showed no significant difference between the highest and the lowest coffee intake categories (OR=0.84, 95% CI 0.65 to 1.09; p=0.20). However, the overall multivariable adjusted RR for gout showed a significant inverse association between coffee consumption and the incidence of gout (RR=0.43, 95% CI 0.31 to 0.59, p<0.001). CONCLUSIONS: Current evidences are insufficient to validate the association between coffee consumption and a lower risk of HU. Owing to the limited number of studies, the available data show that coffee consumption may be associated with a lower risk of incident gout. Further well-designed prospective researches and randomised controlled trials are therefore needed to elaborate on these issues. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/27401353/Is_coffee_consumption_associated_with_a_lower_risk_of_hyperuricaemia_or_gout_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -