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Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle.
FASEB J 2016; 30(10):3413-3423FJ

Abstract

Increased mitochondrial content and respiration have both been reported after exercise training. However, no study has directly compared how different training volumes influence mitochondrial respiration and markers of mitochondrial biogenesis. Ten healthy men performed high-intensity interval cycling during 3 consecutive training phases; 4 wk of normal-volume training (NVT; 3/wk), followed by 20 d of high-volume training (HVT; 2/d) and 2 wk of reduced-volume training (RVT; 5 sessions). Resting biopsy samples (vastus lateralis) were obtained at baseline and after each phase. No mitochondrial parameter changed after NVT. After HVT, mitochondrial respiration and citrate synthase activity (∼40-50%), as well as the protein content of electron transport system (ETS) subunits (∼10-40%), and that of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), NRF1, mitochondrial transcription factor A (TFAM), PHF20, and p53 (∼65-170%) all increased compared to baseline; mitochondrial specific respiration remained unchanged. After RVT, all the mitochondrial parameters measured except citrate synthase activity (∼36% above initial) were not significantly different compared to baseline (all P > 0.05). Our findings demonstrate that training volume is an important determinant of training-induced mitochondrial adaptations and highlight the rapid reversibility of human skeletal muscle to a reduction in training volume.-Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., Bishop, D. J. Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle.

Authors+Show Affiliations

Institute of Sport, Exercise, and Active Living, College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia.Institute of Sport, Exercise, and Active Living, College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia.School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; and.Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany.Institute of Sport, Exercise, and Active Living, College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia; david.bishop@vu.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27402675

Citation

Granata, Cesare, et al. "Mitochondrial Adaptations to High-volume Exercise Training Are Rapidly Reversed After a Reduction in Training Volume in Human Skeletal Muscle." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 30, no. 10, 2016, pp. 3413-3423.
Granata C, Oliveira RS, Little JP, et al. Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J. 2016;30(10):3413-3423.
Granata, C., Oliveira, R. S., Little, J. P., Renner, K., & Bishop, D. J. (2016). Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 30(10), pp. 3413-3423.
Granata C, et al. Mitochondrial Adaptations to High-volume Exercise Training Are Rapidly Reversed After a Reduction in Training Volume in Human Skeletal Muscle. FASEB J. 2016;30(10):3413-3423. PubMed PMID: 27402675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. AU - Granata,Cesare, AU - Oliveira,Rodrigo S F, AU - Little,Jonathan P, AU - Renner,Kathrin, AU - Bishop,David J, Y1 - 2016/07/11/ PY - 2016/03/08/received PY - 2016/06/21/accepted PY - 2016/7/13/pubmed PY - 2017/9/9/medline PY - 2016/7/13/entrez KW - PGC-1α KW - PHF20 KW - mitochondrial biogenesis KW - mitochondrial respiration KW - p53 SP - 3413 EP - 3423 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J. VL - 30 IS - 10 N2 - Increased mitochondrial content and respiration have both been reported after exercise training. However, no study has directly compared how different training volumes influence mitochondrial respiration and markers of mitochondrial biogenesis. Ten healthy men performed high-intensity interval cycling during 3 consecutive training phases; 4 wk of normal-volume training (NVT; 3/wk), followed by 20 d of high-volume training (HVT; 2/d) and 2 wk of reduced-volume training (RVT; 5 sessions). Resting biopsy samples (vastus lateralis) were obtained at baseline and after each phase. No mitochondrial parameter changed after NVT. After HVT, mitochondrial respiration and citrate synthase activity (∼40-50%), as well as the protein content of electron transport system (ETS) subunits (∼10-40%), and that of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), NRF1, mitochondrial transcription factor A (TFAM), PHF20, and p53 (∼65-170%) all increased compared to baseline; mitochondrial specific respiration remained unchanged. After RVT, all the mitochondrial parameters measured except citrate synthase activity (∼36% above initial) were not significantly different compared to baseline (all P > 0.05). Our findings demonstrate that training volume is an important determinant of training-induced mitochondrial adaptations and highlight the rapid reversibility of human skeletal muscle to a reduction in training volume.-Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., Bishop, D. J. Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/27402675/Mitochondrial_adaptations_to_high_volume_exercise_training_are_rapidly_reversed_after_a_reduction_in_training_volume_in_human_skeletal_muscle_ L2 - http://www.fasebj.org/doi/full/10.1096/fj.201500100R?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -