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Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections.
Epidemiol Infect 2016; 144(15):3226-3236EI

Abstract

The incidence of childhood respiratory infections in Greenland is among the highest globally. We performed a population-based study of 352 Greenlandic children aged 0-6 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. Nasopharyngeal swabs were tested for Streptococcus pneumoniae grouped by serotypes included (VT) or not included (NVT) in the 13-valent pneumococcal conjugate vaccine, non-typable Haemophilus influenzae (NTHi), Staphylococcus aureus and Moraxella catarrhalis. S. pneumoniae was detected from age 2 weeks with a peak carriage rate of 60% in 2-year-olds. Young age and having siblings attending a daycare institution were associated with pneumococcal carriage. Overall co-colonization with ⩾2 of the studied bacteria was 52%. NTHi showed a positive association with NVT pneumococci and M. catarrhalis, respectively, M. catarrhalis was positively associated with S. pneumoniae, particular VT pneumococci, whereas S. aureus were negatively associated with NTHi and M. catarrhalis. Nasopharyngeal bacterial carriage was present unusually early in life and with frequent co-colonization. Domestic crowding increased odds of carriage. Due to important bacterial associations we suggest future surveillance of pneumococcal conjugate vaccine's impact on carriage in Greenland to also include other pathogens.

Authors+Show Affiliations

Department of Epidemiology Research,Statens Serum Institut,Copenhagen,Denmark.Department of Epidemiology Research,Statens Serum Institut,Copenhagen,Denmark.Department of Microbiology and Infection Control,Statens Serum Institut,Copenhagen,Denmark.Department of Epidemiology Research,Statens Serum Institut,Copenhagen,Denmark.Department of Epidemiology Research,Statens Serum Institut,Copenhagen,Denmark.Department of Internal Medicine,Queen Ingrid's Hospital,Nuuk,Greenland.Department of Epidemiology Research,Statens Serum Institut,Copenhagen,Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27405603

Citation

Navne, J E., et al. "Nasopharyngeal Bacterial Carriage in Young Children in Greenland: a Population at High Risk of Respiratory Infections." Epidemiology and Infection, vol. 144, no. 15, 2016, pp. 3226-3236.
Navne JE, Børresen ML, Slotved HC, et al. Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections. Epidemiol Infect. 2016;144(15):3226-3236.
Navne, J. E., Børresen, M. L., Slotved, H. C., Andersson, M., Melbye, M., Ladefoged, K., & Koch, A. (2016). Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections. Epidemiology and Infection, 144(15), pp. 3226-3236.
Navne JE, et al. Nasopharyngeal Bacterial Carriage in Young Children in Greenland: a Population at High Risk of Respiratory Infections. Epidemiol Infect. 2016;144(15):3226-3236. PubMed PMID: 27405603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections. AU - Navne,J E, AU - Børresen,M L, AU - Slotved,H C, AU - Andersson,M, AU - Melbye,M, AU - Ladefoged,K, AU - Koch,A, Y1 - 2016/07/13/ PY - 2016/7/14/pubmed PY - 2017/6/10/medline PY - 2016/7/14/entrez KW - Children KW - Greenland KW - Inuit KW - PCV-13 KW - nasopharyngeal carriage KW - pneumococci KW - risk factors SP - 3226 EP - 3236 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 144 IS - 15 N2 - The incidence of childhood respiratory infections in Greenland is among the highest globally. We performed a population-based study of 352 Greenlandic children aged 0-6 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. Nasopharyngeal swabs were tested for Streptococcus pneumoniae grouped by serotypes included (VT) or not included (NVT) in the 13-valent pneumococcal conjugate vaccine, non-typable Haemophilus influenzae (NTHi), Staphylococcus aureus and Moraxella catarrhalis. S. pneumoniae was detected from age 2 weeks with a peak carriage rate of 60% in 2-year-olds. Young age and having siblings attending a daycare institution were associated with pneumococcal carriage. Overall co-colonization with ⩾2 of the studied bacteria was 52%. NTHi showed a positive association with NVT pneumococci and M. catarrhalis, respectively, M. catarrhalis was positively associated with S. pneumoniae, particular VT pneumococci, whereas S. aureus were negatively associated with NTHi and M. catarrhalis. Nasopharyngeal bacterial carriage was present unusually early in life and with frequent co-colonization. Domestic crowding increased odds of carriage. Due to important bacterial associations we suggest future surveillance of pneumococcal conjugate vaccine's impact on carriage in Greenland to also include other pathogens. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/27405603/Nasopharyngeal_bacterial_carriage_in_young_children_in_Greenland:_a_population_at_high_risk_of_respiratory_infections_ L2 - https://www.cambridge.org/core/product/identifier/S0950268816001461/type/journal_article DB - PRIME DP - Unbound Medicine ER -