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Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
J Am Heart Assoc. 2016 07 12; 5(7)JA

Abstract

BACKGROUND

Quercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. We assessed the impact of quercetin on BP through a systematic review and meta-analysis of available randomized controlled trials.

METHODS AND RESULTS

We searched PUBMED, Cochrane Library, Scopus, and EMBASE up to January 31, 2015 to identify placebo-controlled randomized controlled trials investigating the effect of quercetin on BP. Meta-analysis was performed using either a fixed-effects or random-effect model according to I(2) statistic. Effect size was expressed as weighted mean difference (WMD) and 95% CI. Overall, the impact of quercetin on BP was reported in 7 trials comprising 9 treatment arms (587 patients). The results of the meta-analysis showed significant reductions both in systolic BP (WMD: -3.04 mm Hg, 95% CI: -5.75, -0.33, P=0.028) and diastolic BP (WMD: -2.63 mm Hg, 95% CI: -3.26, -2.01, P<0.001) following supplementation with quercetin. When the studies were categorized according to the quercetin dose, there was a significant systolic BP and diastolic BP-reducing effect in randomized controlled trials with doses ≥500 mg/day (WMD: -4.45 mm Hg, 95% CI: -7.70, -1.21, P=0.007 and -2.98 mm Hg, 95% CI: -3.64, -2.31, P<0.001, respectively), and lack of a significant effect for doses <500 mg/day (WMD: -1.59 mm Hg, 95% CI: -4.44, 1.25, P=0.273 and -0.24 mm Hg, 95% CI: -2.00, 1.52, P=0.788, respectively), but indirect comparison tests failed to significant differences between doses.

CONCLUSIONS

The results of the meta-analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. Further studies are necessary to investigate the clinical relevance of these results and the possibility of quercetin application as an add-on to antihypertensive therapy.

Authors+Show Affiliations

University of Alabama at Birmingham, AL University of Medicine and Pharmacy, Timisoara, Romania.Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Istituto Auxologico Italiano and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Università di Milano, Italy.Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK.University of Alabama at Birmingham, AL.University of Medicine and Pharmacy, Timisoara, Romania.University of Medicine and Pharmacy, Timisoara, Romania.Washington DC Veterans Affairs Medical Center, Washington, DC.New York Medical College, Valhalla, NY.University of Alabama at Birmingham, AL.University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.Erasmus MC-University Medical Center Rotterdam, the Netherlands.University of California, Irvine, CA.Medical University of Lodz, Poland.Medical University of Lodz, Poland maciejbanach@aol.co.uk.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27405810

Citation

Serban, Maria-Corina, et al. "Effects of Quercetin On Blood Pressure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of the American Heart Association, vol. 5, no. 7, 2016.
Serban MC, Sahebkar A, Zanchetti A, et al. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016;5(7).
Serban, M. C., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., Andrica, F., Ahmed, A., Aronow, W. S., Muntner, P., Lip, G. Y., Graham, I., Wong, N., Rysz, J., & Banach, M. (2016). Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of the American Heart Association, 5(7). https://doi.org/10.1161/JAHA.115.002713
Serban MC, et al. Effects of Quercetin On Blood Pressure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016 07 12;5(7) PubMed PMID: 27405810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. AU - Serban,Maria-Corina, AU - Sahebkar,Amirhossein, AU - Zanchetti,Alberto, AU - Mikhailidis,Dimitri P, AU - Howard,George, AU - Antal,Diana, AU - Andrica,Florina, AU - Ahmed,Ali, AU - Aronow,Wilbert S, AU - Muntner,Paul, AU - Lip,Gregory Y H, AU - Graham,Ian, AU - Wong,Nathan, AU - Rysz,Jacek, AU - Banach,Maciej, AU - ,, Y1 - 2016/07/12/ PY - 2016/7/14/entrez PY - 2016/7/15/pubmed PY - 2018/1/6/medline KW - blood pressure KW - flavonoids KW - high blood pressure KW - hypertension KW - lipids KW - meta‐analysis KW - nutrition KW - quercetin JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 5 IS - 7 N2 - BACKGROUND: Quercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. We assessed the impact of quercetin on BP through a systematic review and meta-analysis of available randomized controlled trials. METHODS AND RESULTS: We searched PUBMED, Cochrane Library, Scopus, and EMBASE up to January 31, 2015 to identify placebo-controlled randomized controlled trials investigating the effect of quercetin on BP. Meta-analysis was performed using either a fixed-effects or random-effect model according to I(2) statistic. Effect size was expressed as weighted mean difference (WMD) and 95% CI. Overall, the impact of quercetin on BP was reported in 7 trials comprising 9 treatment arms (587 patients). The results of the meta-analysis showed significant reductions both in systolic BP (WMD: -3.04 mm Hg, 95% CI: -5.75, -0.33, P=0.028) and diastolic BP (WMD: -2.63 mm Hg, 95% CI: -3.26, -2.01, P<0.001) following supplementation with quercetin. When the studies were categorized according to the quercetin dose, there was a significant systolic BP and diastolic BP-reducing effect in randomized controlled trials with doses ≥500 mg/day (WMD: -4.45 mm Hg, 95% CI: -7.70, -1.21, P=0.007 and -2.98 mm Hg, 95% CI: -3.64, -2.31, P<0.001, respectively), and lack of a significant effect for doses <500 mg/day (WMD: -1.59 mm Hg, 95% CI: -4.44, 1.25, P=0.273 and -0.24 mm Hg, 95% CI: -2.00, 1.52, P=0.788, respectively), but indirect comparison tests failed to significant differences between doses. CONCLUSIONS: The results of the meta-analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. Further studies are necessary to investigate the clinical relevance of these results and the possibility of quercetin application as an add-on to antihypertensive therapy. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/27405810/Effects_of_Quercetin_on_Blood_Pressure:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Controlled_Trials_ L2 - http://www.ahajournals.org/doi/full/10.1161/JAHA.115.002713?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -