Tags

Type your tag names separated by a space and hit enter

Dietary habits and neurological features of Parkinson's disease patients: Implications for practice.
Clin Nutr. 2017 08; 36(4):1054-1061.CN

Abstract

BACKGROUND & AIMS

Parkinson's disease (PD) patients can benefit considerably from appropriate nutritional care, particularly from diet. However, there is limited evidence on the eating habits of PD patients and their relationship with the features of the disease.

METHODS

We conducted a large case-control study. Consecutive PD patients (N = 600) receiving systematic nutritional care and healthy controls (N = 600) matched (1:1) for age, gender, education, physical activity level and residence were studied using a 66-item food frequency questionnaire. The relationship between dietary habits and the following features of PD were investigated in patients: body weight, energy balance, constipation, and levodopa therapy (dose) and its related motor complications.

RESULTS

PD patients had lower BMI and reported higher food intake than controls. BMI was found to be inversely associated with disease duration and severity, and levodopa-related motor complications, whereas energy intake was positively associated with these variables. An increase in protein intake by 10 g over physiological requirements (0.8 g/kg/day) corresponded to a mean increase in levodopa dose of 0.7 mg/kg/day. Constipation was also associated with higher levodopa requirements. Finally, protein intake and its distribution throughout the day influenced levodopa-related motor complications.

CONCLUSION

The management of protein intake and the treatment of constipation should be considered to be an integral part of the care of PD patients. Attention should always be focused on energy intake also. This would result in the maintenance of nutritional status, the optimization of levodopa-therapy and the minimization of its related motor complications.

Authors+Show Affiliations

Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: e.cereda@smatteo.pv.it.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.Department of Statistical Sciences "P. Fortunati", University of Bologna, Bologna, Italy.Department of Parkinson Disease Rehabilitation, Moriggia-Pelascini Hospital, Gravedona ed Uniti, Fondazione Europea Ricerca Biomedica (FERB), "S.Isidoro" Hospital, Trescore Balneario, Italy.Department of Functional Rehabilitation, "Sol et Salus" Hospital, Torre Pedrera, Rimini, Italy.Parkinson Institute, ASST G.Pini-CTO, ex ICP, Milan, Italy.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

27406858

Citation

Barichella, Michela, et al. "Dietary Habits and Neurological Features of Parkinson's Disease Patients: Implications for Practice." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 4, 2017, pp. 1054-1061.
Barichella M, Cereda E, Cassani E, et al. Dietary habits and neurological features of Parkinson's disease patients: Implications for practice. Clin Nutr. 2017;36(4):1054-1061.
Barichella, M., Cereda, E., Cassani, E., Pinelli, G., Iorio, L., Ferri, V., Privitera, G., Pasqua, M., Valentino, A., Monajemi, F., Caronni, S., Lignola, C., Pusani, C., Bolliri, C., Faierman, S. A., Lubisco, A., Frazzitta, G., Petroni, M. L., & Pezzoli, G. (2017). Dietary habits and neurological features of Parkinson's disease patients: Implications for practice. Clinical Nutrition (Edinburgh, Scotland), 36(4), 1054-1061. https://doi.org/10.1016/j.clnu.2016.06.020
Barichella M, et al. Dietary Habits and Neurological Features of Parkinson's Disease Patients: Implications for Practice. Clin Nutr. 2017;36(4):1054-1061. PubMed PMID: 27406858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary habits and neurological features of Parkinson's disease patients: Implications for practice. AU - Barichella,Michela, AU - Cereda,Emanuele, AU - Cassani,Erica, AU - Pinelli,Giovanna, AU - Iorio,Laura, AU - Ferri,Valentina, AU - Privitera,Giulia, AU - Pasqua,Marianna, AU - Valentino,Angela, AU - Monajemi,Fatemeh, AU - Caronni,Serena, AU - Lignola,Caterina, AU - Pusani,Chiara, AU - Bolliri,Carlotta, AU - Faierman,Samanta A, AU - Lubisco,Alessandro, AU - Frazzitta,Giuseppe, AU - Petroni,Maria L, AU - Pezzoli,Gianni, Y1 - 2016/07/05/ PY - 2016/03/24/received PY - 2016/06/01/revised PY - 2016/06/27/accepted PY - 2016/7/14/pubmed PY - 2018/3/27/medline PY - 2016/7/14/entrez KW - Body weight KW - Diet KW - Gastrointestinal dysfunction KW - Levodopa KW - Motor fluctuations KW - Parkinson's disease SP - 1054 EP - 1061 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 4 N2 - BACKGROUND & AIMS: Parkinson's disease (PD) patients can benefit considerably from appropriate nutritional care, particularly from diet. However, there is limited evidence on the eating habits of PD patients and their relationship with the features of the disease. METHODS: We conducted a large case-control study. Consecutive PD patients (N = 600) receiving systematic nutritional care and healthy controls (N = 600) matched (1:1) for age, gender, education, physical activity level and residence were studied using a 66-item food frequency questionnaire. The relationship between dietary habits and the following features of PD were investigated in patients: body weight, energy balance, constipation, and levodopa therapy (dose) and its related motor complications. RESULTS: PD patients had lower BMI and reported higher food intake than controls. BMI was found to be inversely associated with disease duration and severity, and levodopa-related motor complications, whereas energy intake was positively associated with these variables. An increase in protein intake by 10 g over physiological requirements (0.8 g/kg/day) corresponded to a mean increase in levodopa dose of 0.7 mg/kg/day. Constipation was also associated with higher levodopa requirements. Finally, protein intake and its distribution throughout the day influenced levodopa-related motor complications. CONCLUSION: The management of protein intake and the treatment of constipation should be considered to be an integral part of the care of PD patients. Attention should always be focused on energy intake also. This would result in the maintenance of nutritional status, the optimization of levodopa-therapy and the minimization of its related motor complications. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/27406858/Dietary_habits_and_neurological_features_of_Parkinson's_disease_patients:_Implications_for_practice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(16)30155-8 DB - PRIME DP - Unbound Medicine ER -