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MicroRNAs in glaucoma and neurodegenerative diseases.
J Hum Genet. 2017 Jan; 62(1):105-112.JH

Abstract

MicroRNAs (miRNAs) constitute a class of short, non-coding RNAs, which have important role in post-transcriptional regulation of genes expression by base-pairing with their target messenger RNA (mRNA). In recent years, miRNAs biogenesis, gene silencing mechanism and implication in various diseases have been thoroughly investigated. Many scientific findings indicate the altered expression of specific miRNA in the brains of patients affected by neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease and Huntington disease. The progressive optic nerve neuropathy associated with changed miRNA profile was also observed during glaucoma development. This suggests that the miRNAs may have a crucial role in these disorders, contributing to the neuronal cell death. A better understanding of molecular mechanism of these disorders will open a new potential way of ND treatment. In this review, the miRNAs role in particular neurodegenerative disorders and their possible application in medicine was discussed.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Molasy M
Department of Clinical Chemistry and Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Walczak A
Department of Clinical Chemistry and Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Szaflik J
Department of Ophthalmology, SPKSO Ophthalmic Hospital, Medical University of Warsaw, Warsaw, Poland.
Szaflik JP
Department of Ophthalmology, SPKSO Ophthalmic Hospital, Medical University of Warsaw, Warsaw, Poland.
Majsterek I
Department of Clinical Chemistry and Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.

MeSH

Cell NucleusGene Expression RegulationGlaucomaHumansMicroRNAsModels, GeneticNeurodegenerative DiseasesProtein BiosynthesisRNA TransportRNA, Messenger

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27412874

Citation

Molasy, Milena, et al. "MicroRNAs in Glaucoma and Neurodegenerative Diseases." Journal of Human Genetics, vol. 62, no. 1, 2017, pp. 105-112.
Molasy M, Walczak A, Szaflik J, et al. MicroRNAs in glaucoma and neurodegenerative diseases. J Hum Genet. 2017;62(1):105-112.
Molasy, M., Walczak, A., Szaflik, J., Szaflik, J. P., & Majsterek, I. (2017). MicroRNAs in glaucoma and neurodegenerative diseases. Journal of Human Genetics, 62(1), 105-112. https://doi.org/10.1038/jhg.2016.91
Molasy M, et al. MicroRNAs in Glaucoma and Neurodegenerative Diseases. J Hum Genet. 2017;62(1):105-112. PubMed PMID: 27412874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs in glaucoma and neurodegenerative diseases. AU - Molasy,Milena, AU - Walczak,Anna, AU - Szaflik,Jerzy, AU - Szaflik,Jacek P, AU - Majsterek,Ireneusz, Y1 - 2016/07/14/ PY - 2016/03/31/received PY - 2016/06/17/revised PY - 2016/06/20/accepted PY - 2016/7/15/pubmed PY - 2017/4/25/medline PY - 2016/7/15/entrez SP - 105 EP - 112 JF - Journal of human genetics JO - J Hum Genet VL - 62 IS - 1 N2 - MicroRNAs (miRNAs) constitute a class of short, non-coding RNAs, which have important role in post-transcriptional regulation of genes expression by base-pairing with their target messenger RNA (mRNA). In recent years, miRNAs biogenesis, gene silencing mechanism and implication in various diseases have been thoroughly investigated. Many scientific findings indicate the altered expression of specific miRNA in the brains of patients affected by neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease and Huntington disease. The progressive optic nerve neuropathy associated with changed miRNA profile was also observed during glaucoma development. This suggests that the miRNAs may have a crucial role in these disorders, contributing to the neuronal cell death. A better understanding of molecular mechanism of these disorders will open a new potential way of ND treatment. In this review, the miRNAs role in particular neurodegenerative disorders and their possible application in medicine was discussed. SN - 1435-232X UR - https://www.unboundmedicine.com/medline/citation/27412874/MicroRNAs_in_glaucoma_and_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -