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Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator.
Oxid Med Cell Longev. 2016; 2016:9049782.OM

Abstract

Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO). H2S exerts universal cytoprotective effects and acts as a defense mechanism in organisms ranging from bacteria to mammals. It is produced by the enzymes cystathionine β-synthase (CBS), cystathionine ϒ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST), and D-amino acid oxidase (DAO), which are also involved in tissue-specific biochemical pathways for H2S production in the human body. H2S exerts a wide range of pathological and physiological functions in the human body, from endocrine system and cellular longevity to hepatic protection and kidney function. Previous studies have shown that H2S plays important roles in peripheral nerve regeneration and degeneration and has significant value during Schwann cell dedifferentiation and proliferation but it is also associated with axonal degradation and the remyelination of Schwann cells. To date, physiological and toxic levels of H2S in the human body remain unclear and most of the mechanisms of action underlying the effects of H2S have yet to be fully elucidated. The primary purpose of this review was to provide an overview of the role of H2S in the human body and to describe its beneficial effects.

Authors+Show Affiliations

Department of Biomedical Science, Graduate School, Kyung Hee University, No. 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, No. 262, Gamcheon-ro, Seo-gu, Busan 49267, Republic of Korea.Department of Biomedical Science, Graduate School, Kyung Hee University, No. 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, No. 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, No. 32, Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27413423

Citation

Panthi, Sandesh, et al. "Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator." Oxidative Medicine and Cellular Longevity, vol. 2016, 2016, p. 9049782.
Panthi S, Chung HJ, Jung J, et al. Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxid Med Cell Longev. 2016;2016:9049782.
Panthi, S., Chung, H. J., Jung, J., & Jeong, N. Y. (2016). Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxidative Medicine and Cellular Longevity, 2016, 9049782. https://doi.org/10.1155/2016/9049782
Panthi S, et al. Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxid Med Cell Longev. 2016;2016:9049782. PubMed PMID: 27413423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. AU - Panthi,Sandesh, AU - Chung,Hyung-Joo, AU - Jung,Junyang, AU - Jeong,Na Young, Y1 - 2016/06/20/ PY - 2016/04/06/received PY - 2016/05/24/accepted PY - 2016/7/15/entrez PY - 2016/7/15/pubmed PY - 2017/3/14/medline SP - 9049782 EP - 9049782 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2016 N2 - Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO). H2S exerts universal cytoprotective effects and acts as a defense mechanism in organisms ranging from bacteria to mammals. It is produced by the enzymes cystathionine β-synthase (CBS), cystathionine ϒ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST), and D-amino acid oxidase (DAO), which are also involved in tissue-specific biochemical pathways for H2S production in the human body. H2S exerts a wide range of pathological and physiological functions in the human body, from endocrine system and cellular longevity to hepatic protection and kidney function. Previous studies have shown that H2S plays important roles in peripheral nerve regeneration and degeneration and has significant value during Schwann cell dedifferentiation and proliferation but it is also associated with axonal degradation and the remyelination of Schwann cells. To date, physiological and toxic levels of H2S in the human body remain unclear and most of the mechanisms of action underlying the effects of H2S have yet to be fully elucidated. The primary purpose of this review was to provide an overview of the role of H2S in the human body and to describe its beneficial effects. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/27413423/Physiological_Importance_of_Hydrogen_Sulfide:_Emerging_Potent_Neuroprotector_and_Neuromodulator_ L2 - https://doi.org/10.1155/2016/9049782 DB - PRIME DP - Unbound Medicine ER -