Tags

Type your tag names separated by a space and hit enter

Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait.
Am J Med. 1989 Jul; 87(1):48-56.AJ

Abstract

PURPOSE

The association between sickle cell trait (SCT) and complications related to exercise may be explained if exercise-induced sickling interferes with capillary blood flow and causes tissue ischemia and functional abnormalities. To test this hypothesis, we measured sickling and blood gas values in venous and arterial blood of an exercising limb in subjects with SCT and in controls.

SUBJECTS AND METHODS

The study consisted of 15 subjects with hemoglobin AS (SCT group) and 15 subjects with hemoglobin AA (control group). Each performed two maximal arm crank exercise tests, one at 1,270 meters and one at simulated 4,000 meters.

RESULTS

At 1,270 meters, axillary venous sickling increased significantly (p less than 0.05) from (mean +/- SD) 1.0 +/- 1.0% at rest to 2.3 +/- 2.6% during peak exercise. At simulated 4,000 meters, sickling increased significantly (p less than 0.001) from 1.5 +/- 1.2% to 8.5 +/- 7.1%. A wide range of sickling during peak exercise was observed (1% to 25%). One minute after exercise at simulated 4,000 meters, venous sickling remained elevated (7.2 +/- 7.8%) despite high levels of oxygen saturation. Arterial sickling (less than 1%) was present in only two subjects. There was no significant difference in oxygen consumption (29.4 +/- 3 versus 30.7 +/- 4 mL/kg/minute) between the subjects with SCT and the controls, nor was there a correlation between exercise performance and sickling (r less than 0.2).

CONCLUSION

We conclude that exercise at 1,270 meters slightly, albeit significantly, increased sickling in blood from an exercising limb and that simulated 4,000 meters dramatically potentiated this effect. Sickling in the effluent blood of an exercising limb does not appear to measurably affect overall maximal arm crank exercise performance.

Authors+Show Affiliations

Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, Texas 79920-5001.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2741981

Citation

Martin, T W., et al. "Exercise and Hypoxia Increase Sickling in Venous Blood From an Exercising Limb in Individuals With Sickle Cell Trait." The American Journal of Medicine, vol. 87, no. 1, 1989, pp. 48-56.
Martin TW, Weisman IM, Zeballos RJ, et al. Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. Am J Med. 1989;87(1):48-56.
Martin, T. W., Weisman, I. M., Zeballos, R. J., & Stephenson, S. R. (1989). Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. The American Journal of Medicine, 87(1), 48-56.
Martin TW, et al. Exercise and Hypoxia Increase Sickling in Venous Blood From an Exercising Limb in Individuals With Sickle Cell Trait. Am J Med. 1989;87(1):48-56. PubMed PMID: 2741981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. AU - Martin,T W, AU - Weisman,I M, AU - Zeballos,R J, AU - Stephenson,S R, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 48 EP - 56 JF - The American journal of medicine JO - Am J Med VL - 87 IS - 1 N2 - PURPOSE: The association between sickle cell trait (SCT) and complications related to exercise may be explained if exercise-induced sickling interferes with capillary blood flow and causes tissue ischemia and functional abnormalities. To test this hypothesis, we measured sickling and blood gas values in venous and arterial blood of an exercising limb in subjects with SCT and in controls. SUBJECTS AND METHODS: The study consisted of 15 subjects with hemoglobin AS (SCT group) and 15 subjects with hemoglobin AA (control group). Each performed two maximal arm crank exercise tests, one at 1,270 meters and one at simulated 4,000 meters. RESULTS: At 1,270 meters, axillary venous sickling increased significantly (p less than 0.05) from (mean +/- SD) 1.0 +/- 1.0% at rest to 2.3 +/- 2.6% during peak exercise. At simulated 4,000 meters, sickling increased significantly (p less than 0.001) from 1.5 +/- 1.2% to 8.5 +/- 7.1%. A wide range of sickling during peak exercise was observed (1% to 25%). One minute after exercise at simulated 4,000 meters, venous sickling remained elevated (7.2 +/- 7.8%) despite high levels of oxygen saturation. Arterial sickling (less than 1%) was present in only two subjects. There was no significant difference in oxygen consumption (29.4 +/- 3 versus 30.7 +/- 4 mL/kg/minute) between the subjects with SCT and the controls, nor was there a correlation between exercise performance and sickling (r less than 0.2). CONCLUSION: We conclude that exercise at 1,270 meters slightly, albeit significantly, increased sickling in blood from an exercising limb and that simulated 4,000 meters dramatically potentiated this effect. Sickling in the effluent blood of an exercising limb does not appear to measurably affect overall maximal arm crank exercise performance. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/2741981/Exercise_and_hypoxia_increase_sickling_in_venous_blood_from_an_exercising_limb_in_individuals_with_sickle_cell_trait_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(89)80482-6 DB - PRIME DP - Unbound Medicine ER -