Tags

Type your tag names separated by a space and hit enter

Aerobic fitness is associated with greater hippocampal cerebral blood flow in children.
Dev Cogn Neurosci 2016; 20:52-8DC

Abstract

The present study is the first to investigate whether cerebral blood flow in the hippocampus relates to aerobic fitness in children. In particular, we used arterial spin labeling (ASL) perfusion MRI to provide a quantitative measure of blood flow in the hippocampus in 73 7- to 9-year-old preadolescent children. Indeed, aerobic fitness was found to relate to greater perfusion in the hippocampus, independent of age, sex, and hippocampal volume. Such results suggest improved microcirculation and cerebral vasculature in preadolescent children with higher levels of aerobic fitness. Further, aerobic fitness may influence how the brain regulates its metabolic demands via blood flow in a region of the brain important for learning and memory. To add specificity to the relationship of fitness to the hippocampus, we demonstrate no significant association between aerobic fitness and cerebral blood flow in the brainstem. Our results reinforce the importance of aerobic fitness during a critical period of child development.

Authors+Show Affiliations

Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address: lchaddo2@illinois.edu.Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.Institute of Biomedical Engineering and Oxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, United Kingdom.Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27419884

Citation

Chaddock-Heyman, Laura, et al. "Aerobic Fitness Is Associated With Greater Hippocampal Cerebral Blood Flow in Children." Developmental Cognitive Neuroscience, vol. 20, 2016, pp. 52-8.
Chaddock-Heyman L, Erickson KI, Chappell MA, et al. Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. Dev Cogn Neurosci. 2016;20:52-8.
Chaddock-Heyman, L., Erickson, K. I., Chappell, M. A., Johnson, C. L., Kienzler, C., Knecht, A., ... Kramer, A. F. (2016). Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. Developmental Cognitive Neuroscience, 20, pp. 52-8. doi:10.1016/j.dcn.2016.07.001.
Chaddock-Heyman L, et al. Aerobic Fitness Is Associated With Greater Hippocampal Cerebral Blood Flow in Children. Dev Cogn Neurosci. 2016;20:52-8. PubMed PMID: 27419884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. AU - Chaddock-Heyman,Laura, AU - Erickson,Kirk I, AU - Chappell,Michael A, AU - Johnson,Curtis L, AU - Kienzler,Caitlin, AU - Knecht,Anya, AU - Drollette,Eric S, AU - Raine,Lauren B, AU - Scudder,Mark R, AU - Kao,Shih-Chun, AU - Hillman,Charles H, AU - Kramer,Arthur F, Y1 - 2016/07/04/ PY - 2015/08/26/received PY - 2016/06/30/revised PY - 2016/07/01/accepted PY - 2016/7/16/entrez PY - 2016/7/16/pubmed PY - 2017/9/14/medline KW - Arterial spin labeling KW - Childhood KW - Development KW - Hippocampus KW - Perfusion KW - Physical activity SP - 52 EP - 8 JF - Developmental cognitive neuroscience JO - Dev Cogn Neurosci VL - 20 N2 - The present study is the first to investigate whether cerebral blood flow in the hippocampus relates to aerobic fitness in children. In particular, we used arterial spin labeling (ASL) perfusion MRI to provide a quantitative measure of blood flow in the hippocampus in 73 7- to 9-year-old preadolescent children. Indeed, aerobic fitness was found to relate to greater perfusion in the hippocampus, independent of age, sex, and hippocampal volume. Such results suggest improved microcirculation and cerebral vasculature in preadolescent children with higher levels of aerobic fitness. Further, aerobic fitness may influence how the brain regulates its metabolic demands via blood flow in a region of the brain important for learning and memory. To add specificity to the relationship of fitness to the hippocampus, we demonstrate no significant association between aerobic fitness and cerebral blood flow in the brainstem. Our results reinforce the importance of aerobic fitness during a critical period of child development. SN - 1878-9307 UR - https://www.unboundmedicine.com/medline/citation/27419884/Aerobic_fitness_is_associated_with_greater_hippocampal_cerebral_blood_flow_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-9293(15)30077-3 DB - PRIME DP - Unbound Medicine ER -