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On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota.
Immunol Res. 2017 02; 65(1):242-256.IR

Abstract

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the selective destruction of insulin-producing β cells as result of a complex interplay between genetic, stochastic and environmental factors in genetically susceptible individuals. An increasing amount of experimental data from animal models and humans has supported the role played by imbalanced gut microbiome in T1D pathogenesis. The commensal intestinal microbiota is fundamental for several physiologic mechanisms, including the establishment of immune homeostasis. Alterations in its composition have been correlated to changes in the gut immune system, including defective tolerance to food antigens, intestinal inflammation and enhanced gut permeability. Early findings reported differences in the intestinal microbiome of subjects affected by prediabetes or overt disease compared to healthy individuals. The present review focuses on microbiota-host homeostasis, its alterations, factors that influence microbiome composition and discusses their putative correlation with T1D development. Further studies are necessary to clarify the role played by microbiota modifications in the processes that cause enhanced permeability and the autoimmune mechanisms responsible for T1D onset.

Authors+Show Affiliations

Vismederi Srl, Siena, Italy. Infectivology and Clinical Trials Area, Bambino Gesù Children's Hospital, IRCCS, Viale S. Paolo 15, 00146, Rome, Italy.Infectivology and Clinical Trials Area, Bambino Gesù Children's Hospital, IRCCS, Viale S. Paolo 15, 00146, Rome, Italy. alessandra.fierabracci@opbg.net.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27421719

Citation

Gianchecchi, Elena, and Alessandra Fierabracci. "On the Pathogenesis of Insulin-dependent Diabetes Mellitus: the Role of Microbiota." Immunologic Research, vol. 65, no. 1, 2017, pp. 242-256.
Gianchecchi E, Fierabracci A. On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota. Immunol Res. 2017;65(1):242-256.
Gianchecchi, E., & Fierabracci, A. (2017). On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota. Immunologic Research, 65(1), 242-256. https://doi.org/10.1007/s12026-016-8832-8
Gianchecchi E, Fierabracci A. On the Pathogenesis of Insulin-dependent Diabetes Mellitus: the Role of Microbiota. Immunol Res. 2017;65(1):242-256. PubMed PMID: 27421719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota. AU - Gianchecchi,Elena, AU - Fierabracci,Alessandra, PY - 2016/7/17/pubmed PY - 2018/2/21/medline PY - 2016/7/17/entrez KW - Autoimmune disorders KW - Environmental factors KW - Etiopathogenesis KW - Microbiome KW - Prevention treatment KW - T1D SP - 242 EP - 256 JF - Immunologic research JO - Immunol. Res. VL - 65 IS - 1 N2 - Type 1 diabetes (T1D) is an autoimmune disorder characterized by the selective destruction of insulin-producing β cells as result of a complex interplay between genetic, stochastic and environmental factors in genetically susceptible individuals. An increasing amount of experimental data from animal models and humans has supported the role played by imbalanced gut microbiome in T1D pathogenesis. The commensal intestinal microbiota is fundamental for several physiologic mechanisms, including the establishment of immune homeostasis. Alterations in its composition have been correlated to changes in the gut immune system, including defective tolerance to food antigens, intestinal inflammation and enhanced gut permeability. Early findings reported differences in the intestinal microbiome of subjects affected by prediabetes or overt disease compared to healthy individuals. The present review focuses on microbiota-host homeostasis, its alterations, factors that influence microbiome composition and discusses their putative correlation with T1D development. Further studies are necessary to clarify the role played by microbiota modifications in the processes that cause enhanced permeability and the autoimmune mechanisms responsible for T1D onset. SN - 1559-0755 UR - https://www.unboundmedicine.com/medline/citation/27421719/On_the_pathogenesis_of_insulin_dependent_diabetes_mellitus:_the_role_of_microbiota_ L2 - https://dx.doi.org/10.1007/s12026-016-8832-8 DB - PRIME DP - Unbound Medicine ER -