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Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Apr; 1862(4):382-392.BB

Abstract

Inflammation represents a powerful innate immune response that defends tissue homeostasis. However, the appropriate termination of inflammatory processes is essential to prevent the development of chronic inflammatory disorders. The resolution of inflammation is actively induced by specialized pro-resolving lipid mediators, which include eicosanoids, resolvins, protectins and maresins. The responsible pro-resolution pathways have emerged as promising targets for anti-inflammatory therapies since they mitigate excessive inflammation without compromising the anti-microbial defenses of the host. We have recently shown that the lipid peroxidation of membrane phospholipids, which is associated with inflammatory conditions, generates oxidized phospholipid (OxPL) species with potent pro-resolving activities. These pro-resolving OxPLs contain a cyclopentenone as their common determinant, and are structurally and functionally related to endogenous pro-resolving prostaglandins. Here, we review the regulation of inflammatory responses by OxPLs with particular focus on the bioactivities and structural characteristics of cyclopentenone-OxPLs, and discuss the impact of the responsible signaling pathways on inflammatory diseases. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder.

Authors+Show Affiliations

Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland.Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland. Electronic address: stefan.freigang@pathology.unibe.ch.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27422370

Citation

Friedli, Olivier, and Stefan Freigang. "Cyclopentenone-containing Oxidized Phospholipids and Their Isoprostanes as Pro-resolving Mediators of Inflammation." Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, vol. 1862, no. 4, 2017, pp. 382-392.
Friedli O, Freigang S. Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(4):382-392.
Friedli, O., & Freigang, S. (2017). Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 1862(4), 382-392. https://doi.org/10.1016/j.bbalip.2016.07.006
Friedli O, Freigang S. Cyclopentenone-containing Oxidized Phospholipids and Their Isoprostanes as Pro-resolving Mediators of Inflammation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(4):382-392. PubMed PMID: 27422370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation. AU - Friedli,Olivier, AU - Freigang,Stefan, Y1 - 2016/07/12/ PY - 2016/05/25/received PY - 2016/07/08/revised PY - 2016/07/08/accepted PY - 2016/7/17/pubmed PY - 2017/10/20/medline PY - 2016/7/17/entrez KW - Cyclopentenone KW - Inflammation KW - Isoprostane KW - Nrf2 KW - Oxidized phospholipid KW - Resolution SP - 382 EP - 392 JF - Biochimica et biophysica acta. Molecular and cell biology of lipids JO - Biochim Biophys Acta Mol Cell Biol Lipids VL - 1862 IS - 4 N2 - Inflammation represents a powerful innate immune response that defends tissue homeostasis. However, the appropriate termination of inflammatory processes is essential to prevent the development of chronic inflammatory disorders. The resolution of inflammation is actively induced by specialized pro-resolving lipid mediators, which include eicosanoids, resolvins, protectins and maresins. The responsible pro-resolution pathways have emerged as promising targets for anti-inflammatory therapies since they mitigate excessive inflammation without compromising the anti-microbial defenses of the host. We have recently shown that the lipid peroxidation of membrane phospholipids, which is associated with inflammatory conditions, generates oxidized phospholipid (OxPL) species with potent pro-resolving activities. These pro-resolving OxPLs contain a cyclopentenone as their common determinant, and are structurally and functionally related to endogenous pro-resolving prostaglandins. Here, we review the regulation of inflammatory responses by OxPLs with particular focus on the bioactivities and structural characteristics of cyclopentenone-OxPLs, and discuss the impact of the responsible signaling pathways on inflammatory diseases. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder. SN - 1388-1981 UR - https://www.unboundmedicine.com/medline/citation/27422370/Cyclopentenone_containing_oxidized_phospholipids_and_their_isoprostanes_as_pro_resolving_mediators_of_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(16)30198-6 DB - PRIME DP - Unbound Medicine ER -