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Neuropsychiatric symptoms in Serbian patients with Parkinson's disease.
J Neurol Sci. 2016 Aug 15; 367:342-6.JN

Abstract

BACKGROUND

Parkinson's disease [PD] is associated with wide variety of neuropsychiatric symptoms, although it is primarily considered as a movement disorder.

OBJECTIVE

To examine whether PD patients can be meaningfully classified into subgroups according to their neuropsychiatric symptoms, reported by their caregivers.

METHODS

Three hundred and sixty PD patients [mean age=63.5, SD=10.3] from the academic clinical setting were assessed with the 12-subscale Neuropsychiatric Inventory Questionnaire [NPI]. A two-stage cluster analysis was used to identify the subgroups groups of patients with specific neuropsychiatric profile.

RESULTS

Three hundred and twenty-one PD patients [89%] showed at least one psychiatric symptom. The most common symptoms were anxiety [73.1%], depression [64.7%], and apathy [51.7%], and nighttime disturbance [51.3%], whereas the least common were euphoria [0.3%], and delusions [1.7%]. The mean [SD] total NPI composite score was 16.9 [17.4]. Two hundred eight PD subjects [58%] of the total sample had at least one symptom with a score ≥4. Three clusters were identified: a] Cluster 1, with no or few NPI symptoms [n=200; 55.6%]; b] Cluster 2, with mild to moderate symptoms on depression, anxiety and apathy scales [n=140; 38.9%]; and c] Cluster 3 with high agitation, disinhibition and irritability scores [n=20 patients; 5.6%]. PD subjects with clinically significant neuropsychiatric symptoms were older with more severe motor and cognitive impairment.

CONCLUSIONS

This study emphasizes the high prevalence and importance of neuropsychiatric symptoms in PD patients; therefore clinicians should also focus on treating in parallel with motor symptoms.

Authors+Show Affiliations

Clinic of Neurology, Clinical Center Kragujevac, Serbia.Faculty of Medicine, University of Belgrade, Serbia; Clinic of Neurology, CCS, Serbia.Faculty of Philology, University of Belgrade, Serbia.Faculty of Medicine, University of Belgrade, Serbia; Clinic of Neurology, CCS, Serbia.Faculty of Medicine, University of Belgrade, Serbia; Clinic of Neurology, CCS, Serbia. Electronic address: vladimir.s.kostic@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27423616

Citation

Petrovic, Mirjana, et al. "Neuropsychiatric Symptoms in Serbian Patients With Parkinson's Disease." Journal of the Neurological Sciences, vol. 367, 2016, pp. 342-6.
Petrovic M, Stefanova E, Ziropadja L, et al. Neuropsychiatric symptoms in Serbian patients with Parkinson's disease. J Neurol Sci. 2016;367:342-6.
Petrovic, M., Stefanova, E., Ziropadja, L., Stojkovic, T., & Kostic, V. S. (2016). Neuropsychiatric symptoms in Serbian patients with Parkinson's disease. Journal of the Neurological Sciences, 367, 342-6. https://doi.org/10.1016/j.jns.2016.06.027
Petrovic M, et al. Neuropsychiatric Symptoms in Serbian Patients With Parkinson's Disease. J Neurol Sci. 2016 Aug 15;367:342-6. PubMed PMID: 27423616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychiatric symptoms in Serbian patients with Parkinson's disease. AU - Petrovic,Mirjana, AU - Stefanova,Elka, AU - Ziropadja,Ljubomir, AU - Stojkovic,Tanja, AU - Kostic,Vladimir S, Y1 - 2016/06/13/ PY - 2016/01/14/received PY - 2016/05/12/revised PY - 2016/06/10/accepted PY - 2016/7/18/entrez PY - 2016/7/18/pubmed PY - 2017/5/18/medline KW - Caregiver KW - Cluster analysis KW - Neuropsychiatric inventory SP - 342 EP - 6 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 367 N2 - BACKGROUND: Parkinson's disease [PD] is associated with wide variety of neuropsychiatric symptoms, although it is primarily considered as a movement disorder. OBJECTIVE: To examine whether PD patients can be meaningfully classified into subgroups according to their neuropsychiatric symptoms, reported by their caregivers. METHODS: Three hundred and sixty PD patients [mean age=63.5, SD=10.3] from the academic clinical setting were assessed with the 12-subscale Neuropsychiatric Inventory Questionnaire [NPI]. A two-stage cluster analysis was used to identify the subgroups groups of patients with specific neuropsychiatric profile. RESULTS: Three hundred and twenty-one PD patients [89%] showed at least one psychiatric symptom. The most common symptoms were anxiety [73.1%], depression [64.7%], and apathy [51.7%], and nighttime disturbance [51.3%], whereas the least common were euphoria [0.3%], and delusions [1.7%]. The mean [SD] total NPI composite score was 16.9 [17.4]. Two hundred eight PD subjects [58%] of the total sample had at least one symptom with a score ≥4. Three clusters were identified: a] Cluster 1, with no or few NPI symptoms [n=200; 55.6%]; b] Cluster 2, with mild to moderate symptoms on depression, anxiety and apathy scales [n=140; 38.9%]; and c] Cluster 3 with high agitation, disinhibition and irritability scores [n=20 patients; 5.6%]. PD subjects with clinically significant neuropsychiatric symptoms were older with more severe motor and cognitive impairment. CONCLUSIONS: This study emphasizes the high prevalence and importance of neuropsychiatric symptoms in PD patients; therefore clinicians should also focus on treating in parallel with motor symptoms. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/27423616/Neuropsychiatric_symptoms_in_Serbian_patients_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30358-6 DB - PRIME DP - Unbound Medicine ER -