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Visible light photoelectrochemical aptasensor for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites.
Biosens Bioelectron. 2016 Dec 15; 86:439-445.BB

Abstract

In this work, a label-free photoelectrochemical (PEC) aptasensor was developed for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites. The CdS/g-C3N4 heterojunction effectively prevented the photogenerated charges recombination of g-C3N4 and self-photocorrosion processes of CdS, improving photo-to-current conversion efficiency. The introduced polypyrrole (PPy) nanoparticles could lead to a more effective separation of photogenerated charges, thus resulting in a further increasing of photocurrent. The CdS/PPy/g-C3N4 was firstly employed as the photoactive materials for fabrication of aptasensor, and SH-aptamer was then adsorbed on the CdS/PPy/g-C3N4 modified electrodes through S-Cd bond. With increasing of adenosine concentration, the photocurrent decreased as the formation of SH-aptamer-adenosine bioaffinity complexes. Under optimal conditions, the PEC aptasensor had a sensitive response to adenosine in a linear range of 0.3nmolL(-1) to 200nmolL(-1) with a detection limit of 0.1nmolL(-1). Besides, the as-proposed aptasensor has also been applied in human serum samples analysis. The aptasensor exhibits high sensitivity and good stability, thus opening up a new promising PEC platform for some other small molecules analysis.

Authors+Show Affiliations

Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China. Electronic address: wudan791108@163.com.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27424261

Citation

Liu, Yixin, et al. "Visible Light Photoelectrochemical Aptasensor for Adenosine Detection Based On CdS/PPy/g-C3N4 Nanocomposites." Biosensors & Bioelectronics, vol. 86, 2016, pp. 439-445.
Liu Y, Ma H, Zhang Y, et al. Visible light photoelectrochemical aptasensor for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites. Biosens Bioelectron. 2016;86:439-445.
Liu, Y., Ma, H., Zhang, Y., Pang, X., Fan, D., Wu, D., & Wei, Q. (2016). Visible light photoelectrochemical aptasensor for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites. Biosensors & Bioelectronics, 86, 439-445. https://doi.org/10.1016/j.bios.2016.06.089
Liu Y, et al. Visible Light Photoelectrochemical Aptasensor for Adenosine Detection Based On CdS/PPy/g-C3N4 Nanocomposites. Biosens Bioelectron. 2016 Dec 15;86:439-445. PubMed PMID: 27424261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visible light photoelectrochemical aptasensor for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites. AU - Liu,Yixin, AU - Ma,Hongmin, AU - Zhang,Yong, AU - Pang,Xuehui, AU - Fan,Dawei, AU - Wu,Dan, AU - Wei,Qin, Y1 - 2016/06/30/ PY - 2016/03/28/received PY - 2016/06/29/revised PY - 2016/06/30/accepted PY - 2016/7/18/entrez PY - 2016/7/18/pubmed PY - 2017/2/7/medline KW - Adenosine KW - Aptasensor KW - CdS/PPy/g-C(3)N(4) nanocomposites KW - Photoelectrochemical SP - 439 EP - 445 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 86 N2 - In this work, a label-free photoelectrochemical (PEC) aptasensor was developed for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites. The CdS/g-C3N4 heterojunction effectively prevented the photogenerated charges recombination of g-C3N4 and self-photocorrosion processes of CdS, improving photo-to-current conversion efficiency. The introduced polypyrrole (PPy) nanoparticles could lead to a more effective separation of photogenerated charges, thus resulting in a further increasing of photocurrent. The CdS/PPy/g-C3N4 was firstly employed as the photoactive materials for fabrication of aptasensor, and SH-aptamer was then adsorbed on the CdS/PPy/g-C3N4 modified electrodes through S-Cd bond. With increasing of adenosine concentration, the photocurrent decreased as the formation of SH-aptamer-adenosine bioaffinity complexes. Under optimal conditions, the PEC aptasensor had a sensitive response to adenosine in a linear range of 0.3nmolL(-1) to 200nmolL(-1) with a detection limit of 0.1nmolL(-1). Besides, the as-proposed aptasensor has also been applied in human serum samples analysis. The aptasensor exhibits high sensitivity and good stability, thus opening up a new promising PEC platform for some other small molecules analysis. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/27424261/Visible_light_photoelectrochemical_aptasensor_for_adenosine_detection_based_on_CdS/PPy/g_C3N4_nanocomposites_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(16)30629-7 DB - PRIME DP - Unbound Medicine ER -