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Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. The Finnish cohorts of the Seven Countries Study.
Arch Intern Med. 1989 Jul; 149(7):1589-91.AI

Abstract

In the two most recent cholesterol-lowering drug trials, the achieved reductions in coronary heart disease mortality were offset by increases in mortality due to accidents and violence. A possible biochemical explanation has been suggested for an association between low serum cholesterol level and increased risk of death due to injury. We, therefore, examined the association between serum cholesterol level and risk of death from accidents or violence in the 25-year follow-up of two cohorts of Finnish men (N = 1580). Although a statistically nonsignificant, negative association was observed in one cohort (hazard ratio, 0.84, with a 1 mmol/L increase in cholesterol), the other cohort showed a statistically significant, positive association in multivariate analysis (hazard ratio, 1.39). We conclude that the observed associations between serum cholesterol and deaths from injury in the present study and in cholesterol-lowering trials are probably determined by other, presently unknown factors, or by chance.

Authors+Show Affiliations

Department of Epidemiology, National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2742433

Citation

Pekkanen, J, et al. "Serum Cholesterol and Risk of Accidental or Violent Death in a 25-year Follow-up. the Finnish Cohorts of the Seven Countries Study." Archives of Internal Medicine, vol. 149, no. 7, 1989, pp. 1589-91.
Pekkanen J, Nissinen A, Punsar S, et al. Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. The Finnish cohorts of the Seven Countries Study. Arch Intern Med. 1989;149(7):1589-91.
Pekkanen, J., Nissinen, A., Punsar, S., & Karvonen, M. J. (1989). Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. The Finnish cohorts of the Seven Countries Study. Archives of Internal Medicine, 149(7), 1589-91.
Pekkanen J, et al. Serum Cholesterol and Risk of Accidental or Violent Death in a 25-year Follow-up. the Finnish Cohorts of the Seven Countries Study. Arch Intern Med. 1989;149(7):1589-91. PubMed PMID: 2742433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. The Finnish cohorts of the Seven Countries Study. AU - Pekkanen,J, AU - Nissinen,A, AU - Punsar,S, AU - Karvonen,M J, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 1589 EP - 91 JF - Archives of internal medicine JO - Arch Intern Med VL - 149 IS - 7 N2 - In the two most recent cholesterol-lowering drug trials, the achieved reductions in coronary heart disease mortality were offset by increases in mortality due to accidents and violence. A possible biochemical explanation has been suggested for an association between low serum cholesterol level and increased risk of death due to injury. We, therefore, examined the association between serum cholesterol level and risk of death from accidents or violence in the 25-year follow-up of two cohorts of Finnish men (N = 1580). Although a statistically nonsignificant, negative association was observed in one cohort (hazard ratio, 0.84, with a 1 mmol/L increase in cholesterol), the other cohort showed a statistically significant, positive association in multivariate analysis (hazard ratio, 1.39). We conclude that the observed associations between serum cholesterol and deaths from injury in the present study and in cholesterol-lowering trials are probably determined by other, presently unknown factors, or by chance. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2742433/Serum_cholesterol_and_risk_of_accidental_or_violent_death_in_a_25_year_follow_up__The_Finnish_cohorts_of_the_Seven_Countries_Study_ DB - PRIME DP - Unbound Medicine ER -