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[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].
Sheng Li Ke Xue Jin Zhan. 2016 Feb; 47(1):1-6.SL

Abstract

PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

27424398

Citation

Yan, Yao, et al. "[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]." Sheng Li Ke Xue Jin Zhan [Progress in Physiology], vol. 47, no. 1, 2016, pp. 1-6.
Yan Y, Wang ZB, Tang CK. [PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. Sheng Li Ke Xue Jin Zhan. 2016;47(1):1-6.
Yan, Y., Wang, Z. B., & Tang, C. K. (2016). [PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. Sheng Li Ke Xue Jin Zhan [Progress in Physiology], 47(1), 1-6.
Yan Y, Wang ZB, Tang CK. [PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. Sheng Li Ke Xue Jin Zhan. 2016;47(1):1-6. PubMed PMID: 27424398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. AU - Yan,Yao, AU - Wang,Zong-Bao, AU - Tang,Chao-Ke, PY - 2016/7/19/entrez PY - 2016/7/19/pubmed PY - 2016/9/16/medline SP - 1 EP - 6 JF - Sheng li ke xue jin zhan [Progress in physiology] JO - Sheng Li Ke Xue Jin Zhan VL - 47 IS - 1 N2 - PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids. SN - 0559-7765 UR - https://www.unboundmedicine.com/medline/citation/27424398/[PPARs_Mediate_the_Regulation_of_Energy_Metabolism_By_Long_Chain_Fatty_Acids]_ DB - PRIME DP - Unbound Medicine ER -